Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma

British Journal of Cancer

Volumn 89, Issue 6, 2003, Pages 992-996

  Comella, P ^a   Farris, A ^b   Lorusso, V ^c   Palmeri, S ^d   Maiorino, L ^e   De Lucia, L ^f   Buzzi, F ^g   Mancarella, S ^h   De Vita, F ⁱ   Gambardella, A ⁱ  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^d UNIVERSITY OF PALERMO   (Italy)

^e San Gennaro Hospital   (Italy)

^f City Hospital   (Italy)

^g City Hospital   (Italy)

^h Universit degli Studi di Padova   (Italy)

ⁱ SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

5 fluorouracil; Colorectal carcinoma; Combination chemotherapy; Elderly patients; Irinotecan

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINIC ACID; IRINOTECAN;

ADULT; AGE; AGED; ALOPECIA; ANEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CHOLINERGIC SYSTEM; CLINICAL TRIAL; COLORECTAL CARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; FEBRILE NEUTROPENIA; FEMALE; GENDER; HEART FAILURE; HEART INFARCTION; HUMAN; LIVER DISEASE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUTROPENIA; PHLEBITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; STOMATITIS; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT WITHDRAWAL; WORLD HEALTH ORGANIZATION;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; LEUCOVORIN; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0141956315     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601214     Document Type: Article

References (32)

1. Balducci L, Yates J (2000) General guidelines for the management of older patients with cancer. Oncology (Huntington) 14: 221-227
2. Buroker TR, O'Connel MJ, Wieand HS, Krook JE, Gerstner JB, Mailliard JA, Schaefer PL, Levitt R, Kardinal CG, Gesme DH (1994) Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12: 14-20
3. Chiara S, Nobile MT, Vincenti M, Lionetto R, Gozza A, Barzacchi MG, Sanguineti O, Repetto L, Rosso R (1998) Advanced colorectal cancer in the elderly: results of consecutive trials with 5-fluorouracil-based chemotherapy. Cancer Chemother Pharmacol 42: 336-340
4. Colorectal Cancer Collaborative Group (2000) Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. BMJ 321: 531-535
5. Comella P, De Vita F, Mancarella S, De Lucia L, Biglietto M, Casaretti R, Farris A, Ianniello GP, Lorusso V, Avallone A, Cartenì G, Leo S, Catalano G, De Lena M, Comella G (2000) Biweekly irinotecan or raltitrexed plus 6S-leucovorin and bolus 5-fluorouracil in advanced colorectal carcinoma. A Southern Italy Cooperative Oncology Group phase II/III randomized trial. Ann Oncol 11: 1323-1333
6. Comella P, Crucitta E, De Vita F, De Lucia L, Farris A, Del Gaizo F, Palmeri S, Iannelli A, Mancarella S, Tafuto S, Maiorino L, Buzzi F, De Cataldis G (2002) Addition of either irinotecan or methotrexate to bolus fluorouracil and high-dose leucovorin every two weeks in advanced colorectal carcinoma: a randomized study of the Southern Italy Cooperative Oncology Group. Ann Oncol 13: 866-873
7. Cox DR (1972) Regression models and life tables. J Roy Stat Assoc 34: 187-220
8. Daniele B, Simmonds PD, Best LY, Ross PJ, Cunningham D (1999) Should chemotherapy be used as a treatment of advanced colorectal carcinoma (ACC) in patients over 70 years of age? Eur J Cancer 35: 1640-1649
9. de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18: 2938-2947
10. Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P, Jandik P, Iveson T, Carmichael J, Alakl M, Gruia G, Awad L, Rougier P (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer. A multicentre randomised trial. Lancet 355: 1041-1047
11. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L (1998) Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 16: 1582-1587
12. Hayman J, Langa KM, Kabeto MU, Katz SJ, DeMonner SM, Chernew ME, Slavin MB, Fendrick AM (2001) Estimating the cost of informal caregiving for elderly patients with cancer. J Clin Oncol 19: 3219-3225
13. Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS (1999) Underrepresentation of patients 64 years of age or older in cancer-treatment trials. N Engl J Med 341: 2061-2067
14. International Multicenter Pooled Analysis of B2 Colon Cancer Trials (1999) Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. J Clin Oncol 17: 1356-1363
15. Kaplan EL, Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481
16. Kearney N, Miller M, Paul J, Smith K (2000) Oncology healthcare professionals' attitude towards elderly people. Ann Oncol 11: 599-601
17. Köhne CH, Grothey A, Bokemeyer C, Bontke N, Aapro M (2001) Chemotherapy in elderly patients with colorectal cancer. Ann Oncol 12: 435-442
18. Mamounas E, Wieand S, Wolmark N, Bear HD, Atkins JN, Song K, Jones J, Rockette H (1999) Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 17: 1349-1355
19. Miller AB, Hoogstraten B, Staquet M, Winkler V (1981) Reporting results of cancer treatment. Cancer 47: 207-214
20. Peto R, Pike C, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomised clinical trials requiring prolonged observation on each patient. Br J Cancer 35: 1-39
21. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D (1999) Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 17: 2412-2418
22. Potosky AL, Harlan LC, Kaplan RS, Johnson KA, Lynch CF (2002) Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. J Clin Oncol 20: 1192-1202
23. Repetto L, Fratino L, Audisio RA, Venturino A, Gianni W, Vercelli M, Parodi S, Dal Lago D, Gioia F, Monfardini S, Aapro MS, Serraino D, Zagonel V (2002) Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group Performance Status in elderly cancer patients: an Italian Group for Geriatric Oncology study. J Clin Oncol 20: 494-502
24. Rothemberg ML, Meropol NJ, Poplin EA, Van Cutsem E, Wadler S (2001) Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel. J Clin Oncol 19: 3801-3807
25. Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, Maroun JA, Ackland SP, Locker PK, Pirotta N, Elfring JL, Miller LL (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343: 905-914
26. Sargent DJ, Goldberg RM, Jacobson SD, MacDonald, JC, Labianca R, Haller DG, Shepherd LE, Seitz JF, Francini G (2001a) A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 345: 1091-1097
27. Sargent DJ, Niedzwiecki D, O'Connel MJ, Schilsky RL (2001b) Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer. N Engl J Med 345: 144-145
28. Sundararajan V, Mitra N, Jacobson JS, Grann VR, Heitjan DF, Neugut AI (2002) Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med 136: 349-357
29. Wolmark N, Rockette H, Mamounas E, Jones J, Wieand S, Wickerham DL, Bear HD, Atkins JN, Dimitrov NV, Glass AG, Fisher ER, Fisher B (1999) Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol Nov; 17(11): 3553-3559
30. Yancik R, Ganz PA, Varricchio CG, Conley B (2001) Perspectives on comorbidity and cancer in older patients: Approaches to expand the knowledge base. J Clin Oncol 19: 1147-1151
31. Yancik R, Wesley MN, Ries LA, Havlik RJ, Long S, Edwards BK, Yates JW (1998) Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: A population-based study. Cancer 82: 2123-2134
32. Zanetti R, Crosignani P, Rosso S, Vigane C (1997) Cancer in Italy: Incidence data from Cancer Registries. Vol. 2, 1988-1992. Roma: II Pensiero Scientifico Editore