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Volumn 11, Issue 6, 2009, Pages 1361-1364

Novel 3,4-diazabenzotropone compounds (2,3-benzodiazepin-5-ones): Synthesis, unique reactivity, and biological evaluation

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; DRUG DERIVATIVE; TROPOLONE; TROPONE;

EID: 64049093066     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol900154x     Document Type: Article
Times cited : (15)

References (25)
  • 8
    • 0034703294 scopus 로고    scopus 로고
    • Recently, a diazabicyclic benzotropolone framework has been reported; see: For a recent report on the synthesis of monocyclic 2-azatropone, see: a
    • For a recent report on the synthesis of monocyclic 2-azatropone, see: (a) Takami, S.; Oshida, A.; Tawada, Y.; Kashino, S.; Satake, K.; Kimura, M. J. Org. Chem. 2000, 65, 6093-6096. Recently, a diazabicyclic benzotropolone framework has been reported; see:
    • (2000) J. Org. Chem , vol.65 , pp. 6093-6096
    • Takami, S.1    Oshida, A.2    Tawada, Y.3    Kashino, S.4    Satake, K.5    Kimura, M.6
  • 13
    • 64349102174 scopus 로고    scopus 로고
    • Preparation of these compounds is described in the Supporting Information
    • Preparation of these compounds is described in the Supporting Information.
  • 14
    • 64349088172 scopus 로고    scopus 로고
    • The adduct 6 is likely to be stable only in a solution. Attempts to isolate 6 ended in failure because regeneration of the diazepine 4 took place during the isolation process.
    • The adduct 6 is likely to be stable only in a solution. Attempts to isolate 6 ended in failure because regeneration of the diazepine 4 took place during the isolation process.
  • 15
    • 34250852857 scopus 로고    scopus 로고
    • Recently, decomposition of 1, 2, 3-triazolines with loss of nitrogen to form aziridines has been reported; see: Kim, S.; Lee, Y. M.; Lee, J.; Lee, T.; Fu, Y.; Song, Y.; Cho, J.; Kim, D. J. Org. Chem. 2007, 72, 4886-4891.
    • Recently, decomposition of 1, 2, 3-triazolines with loss of nitrogen to form aziridines has been reported; see: Kim, S.; Lee, Y. M.; Lee, J.; Lee, T.; Fu, Y.; Song, Y.; Cho, J.; Kim, D. J. Org. Chem. 2007, 72, 4886-4891.
  • 19
    • 64349122362 scopus 로고    scopus 로고
    • 4 reduction of 4a (see the Supporting Information), did not participate in the nitrogen extrusion reaction under the optimal conditions.
    • 4 reduction of 4a (see the Supporting Information), did not participate in the nitrogen extrusion reaction under the optimal conditions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.