Self-assembly of Epstein-Barr virus capsids

Journal of Virology

Volumn 83, Issue 8, 2009, Pages 3877-3890

  Henson, Brandon W ^a   Perkins, Edward M ^b   Cothran, Jonathan E ^a   Desai, Prashant ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACULOVIRUS VECTOR; CAPSID PROTEIN; PROTEIN BCLF1; PROTEIN BDLF1; PROTEIN BDRF1; PROTEIN BFRF3; PROTEIN BORF1; PROTEIN BVRF2; PROTEINASE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CELL NUCLEUS; ELECTRON MICROSCOPY; EPSTEIN BARR VIRUS; HERPES VIRUS; INSECT CELL; MIXED INFECTION; MOLECULAR CLONING; MOLECULAR SIZE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEDIMENTATION; VIRUS CAPSID; ANIMAL; ARMYWORM; BACULOVIRUS; CELL LINE; DENSITY GRADIENT CENTRIFUGATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN BINDING; TRANSMISSION ELECTRON MICROSCOPY; VIRUS ASSEMBLY;

HEXAPODA; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 8; LYMPHOCRYPTOVIRUS; MIRIDAE;

ANIMALS; BACULOVIRIDAE; CAPSID; CAPSID PROTEINS; CELL LINE; CENTRIFUGATION, DENSITY GRADIENT; DNA MUTATIONAL ANALYSIS; HERPESVIRUS 4, HUMAN; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; SPODOPTERA; VIRUS ASSEMBLY;

EID: 64049092489     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01733-08     Document Type: Article

References (47)

1. Adamson, W. E., D. McNab, V. G. Preston, and F. J. Rixon. 2006. Mutational analysis of the herpes simplex virus triplex protein VP19C. J. Virol. 80:1537-1548. (Pubitemid 43134109)
2. Addison, C., F. J. Rixon, J. W. Palfreyman, M. O'Hara, and V. G. Preston. 1984. Characterisation of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assembly of capsids. Virology 138:246-259.
3. Borst, E.-M., S. Mathys, M. Wagner, W. Muranyi, and M. Messerle. 2001. Genetic evidence of an essential role for cytomegalovirus small capsid protein in viral growth. J. Virol. 75:1450-1458. (Pubitemid 32094703)
4. Brady, G., G. J. MacArthur, and P. J. Farrell. 2007. Epstein-Barr virus and Burkitt lymphoma. J. Clin. Pathol. 60:1397-1402. (Pubitemid 350247257)
5. Casaday, R. J., J. R. Bailey, S. R. Kalb, E. J. Brignole, A. N. Loveland, R. J. Cotter, and W. Gibson. 2004. Assembly protein precursor (pUL80.5 homolog) of simian cytomegalovirus is phosphorylated at a glycogen synthase kinase 3 site and its downstream "priming" site: phosphorylation affects interactions of protein with itself and with major capsid protein. J. Virol. 78:13501-13511.
6. Chaudhuri, V., M. Sommer, J. Rajamani, L. Zerboni, and A. M. Arvin. 2008. Functions of varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infection. J. Virol. 82:10231-10246.
7. Chelsky, D., R. Ralph, and G. Jonak. 1989. Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol. Cell. Biol. 9:2487-2492. (Pubitemid 19148128)
8. de Jesus, O., P. R. Smith, L. C. Spender, C. Elgueta Karstegl, H. H. Niller, D. Huang, and P. J. Farrell. 2003. Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. J. Gen. Virol. 84:1443-1450. (Pubitemid 36675514)
9. Desai, P., J. C. Akpa, and S. Person. 2003. Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids. J. Virol. 77:391-404. (Pubitemid 36004979)
10. Desai, P., N. A. DeLuca, J. C. Glorioso, and S. Person. 1993. Mutations in herpes simplex virus type 1 genes encoding VP5 and VP23 abrogate capsid formation and cleavage of replicated DNA. J. Virol. 67:1357-1364. (Pubitemid 23067642)
11. Desai, P., and S. Person. 1998. Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid. J. Virol. 72:7563-7568. (Pubitemid 28377889)
12. Desai, P., and S. Person. 1996. Molecular interactions between the HSV-1 capsid proteins as measured by the yeast two-hybrid system. Virology 220:516-521.
13. Donaghy, G., and R. Jupp. 1995. Characterization of the Epstein-Barr virus proteinase and comparison with the human cytomegalovirus proteinase. J. Virol. 69:1265-1270.
14. Donnelly, M., J. Verhagen, and G. Elliott. 2007. RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal. J. Virol. 81:2283-2296. (Pubitemid 46303346)
15. Gao, M., L. Matusick-Kumar, W. Hurlburt, S. F. DiTusa, W. W. Newcomb, J. C. Brown, P. J. McCann III, I. Deckman, and R. J. Colonno. 1994. The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth. J. Virol. 68:3702-3712. (Pubitemid 24177395)
16. Gibson, W., and B. Roizman. 1972. Proteins specified by herpes simplex virus. VIII. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J. Virol. 10:1044-1052.
17. Homa, F. L., and J. C. Brown. 1997. Capsid assembly and DNA packaging in herpes simplex virus. Rev. Med. Virol. 7:107-122. (Pubitemid 27314687)
18. Huang, E., E. M. Perkins, and P. Desai. 2007. Structural features of the scaffold interaction domain at the N terminus of the major capsid protein (VP5) of herpes simplex virus type 1. J. Virol. 81:9396-9407. (Pubitemid 47311482)
19. Johannsen, E., M. Luftig, M. R. Chase, S. Weicksel, E. Cahir-McFarland, D. Illanes, D. Sarracino, and E. Kieff. 2004. Proteins of purified Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 101:16286-16291.
20. Kalderon, D., B. L. Roberts, W. D. Richardson, and A. E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39:499-509.
21. Kennard, J., F. J. Rixon, I. M. McDougall, J. D. Tatman, and V. G. Preston. 1995. The 25 amino acid residues at the carboxy terminus of the herpes simplex virus type 1 UL26.5 protein are required for the formation of the capsid shell around the scaffold. J. Gen. Virol. 76:1611-1621.
22. Kut, E., and D. Rasschaert. 2004. Assembly of Marek's disease virus (MDV) capsids using recombinant baculoviruses expressing MDV capsid proteins. J. Gen. Virol. 85:769-774. (Pubitemid 38489542)
23. Luckow, V. A., S. C. Lee, G. F. Barry, and P. O. Olins. 1993. Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli. J. Virol. 67:4566-4579. (Pubitemid 23215935)
24. McNab, A. R., P. Desai, S. Person, L. L. Roof, D. R. Thomsen, W. W. Newcomb, J. C. Brown, and F. L. Homa. 1998. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA. J. Virol. 72:1060-1070. (Pubitemid 28116885)
25. Molesworth, S. J., C. M. Lake, C. M. Borza, S. M. Turk, and L. M. Hutt-Fletcher. 2000. Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells. J. Virol. 74:6324-6332. (Pubitemid 30429797)
26. Newcomb, W. W., F. L. Homa, D. R. Thomsen, F. P. Booy, B. L. Trus, A. C. Steven, J. V. Spencer, and J. C. Brown. 1996. Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation. J. Mol. Biol. 263:432-446.
27. Newcomb, W. W., F. L. Homa, D. R. Thomsen, B. L. Trus, N. Cheng, A. Steven, F. Booy, and J. C. Brown. 1999. Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins. J. Virol. 73:4239-4250. (Pubitemid 29189869)
28. Newcomb, W. W., B. L. Trus, N. Cheng, A. C. Steven, A. K. Sheaffer, D. J. Tenney, S. K. Weller, and J. C. Brown. 2000. Isolation of herpes simplex virus procapsids from cells infected with a protease-deficient mutant virus. J. Virol. 74:1663-1673. (Pubitemid 30434022)
29. Nicholson, P., C. Addison, A. M. Cross, J. Kennard, V. G. Preston, and F. J. Rixon. 1994. Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a. J. Gen. Virol. 75:1091-1099. (Pubitemid 24143154)
30. Okoye, M. E., G. L. Sexton, E. Huang, J. M. McCaffery, and P. Desai. 2006. Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1. J. Virol. 80:929-940. (Pubitemid 43062905)
31. Perkins, E. M., D. Anacker, A. Davis, V. Sankar, R. F. Ambinder, and P. Desai. 2008. Small capsid protein pORF65 is essential for assembly of Kaposi's sarcoma-associated herpesvirus capsids. J. Virol. 82:7201-7211.
32. Perkins, E. M., and J. M. McCaffery. 2008. Conventional and immunoelectron microscopy of mitochondria. Methods Mol. Biol. 372:467-483.
33. Person, S., and P. Desai. 1998. Capsids are formed in a mutant virus blocked at the maturation site of the UL26 and UL26.5 open reading frames of herpes simplex virus type 1 but are not formed in a null mutant of UL38 (VP19C). Virology 242:193-203.
34. Plafker, S. M., and W. Gibson. 1998. Cytomegalovirus assembly protein precursor and proteinase precursor contain two nuclear localization signals that mediate their own nuclear translocation and that of the major capsid protein. J. Virol. 72:7722-7732. (Pubitemid 28421762)
35. Rixon, F. J. 1993. Structure and assembly of herpesviruses. Semin. Virol. 4:135-144.
36. Rixon, F. J., C. Addison, A. McGregor, S. J. Macnab, P. Nicholson, V. G. Preston, and J. D. Tatman. 1996. Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins. J. Gen. Virol. 77:2251-2260. (Pubitemid 26316096)
37. Rixon, F. J., and D. McNab. 1999. Packaging-competent capsids of a herpes simplex virus temperature-sensitive mutant have properties similar to those of in vitro-assembled procapsids. J. Virol. 73:5714-5721. (Pubitemid 29274857)
38. Salsman, J., N. Zimmerman, T. Chen, M. Domagala, and L. Frappier. 2008. Genome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodies. PLoS Pathog. 4:e1000100.
39. Sheaffer, A. K., W. W. Newcomb, J. C. Brown, M. Gao, S. K. Weller, and D. J. Tenney. 2000. Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids. J. Virol. 74:6838-6848. (Pubitemid 30470667)
40. Spencer, J. V., W. W. Newcomb, D. R. Thomsen, F. L. Homa, and J. C. Brown. 1998. Assembly of the herpes simplex virus capsid: preformed triplexes bind to the nascent capsid. J. Virol. 72:3944-3951.
41. Steven, A. C., and P. G. Spear. 1996. Herpesvirus capsid assembly and envelopment, p. 312-351. In W. Chiu, R. Burnett, and R. Garcea (ed.), Structural biology of viruses. Oxford University Press, Oxford, United Kingdom.
42. Tatman, J. D., V. G. Preston, P. Nicholson, R. M. Elliott, and F. J. Rixon. 1994. Assembly of herpes simplex virus type 1 capsids using a panel of recombinant baculoviruses. J. Gen. Virol. 75:1101-1113. (Pubitemid 24143155)
43. Thomsen, D. R., L. L. Roof, and F. L. Homa. 1994. Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins. J. Virol. 68:2442-2457. (Pubitemid 24091924)
44. Truant, R., and B. R. Cullen. 1999. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin β-dependent nuclear localization signals. Mol. Cell. Biol. 19:1210-1217. (Pubitemid 29046863)
45. Trus, B. L., F. P. Booy, W. W. Newcomb, J. C. Brown, F. L. Homa, D. R. Thomsen, and A. C. Steven. 1996. The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly. J. Mol. Biol. 263:447-462.
46. Vetsika, E. K., and M. Callan. 2004. Infectious mononucleosis and Epstein-Barr virus. Expert Rev. Mol. Med. 6:1-16.
47. Young, L. S., and P. G. Murray. 2003. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene 22:5108-5121.