Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE

Pharmaceutical Research

Volumn 26, Issue 5, 2009, Pages 1226-1235

  Ananth, Sudha ^a   Karunakaran, Senthil ^a   Martin, Pamela M ^a   Nagineni, Chandrasekharam N ^b   Hooks, John J ^b   Smith, Sylvia B ^a   Prasad, Puttur D ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Conjunctival epithelial cell; Non peptide opioid antagonists; Opioid peptides; Organic anion transporting polypeptides; Transport process

Indexed keywords

DELTORPHIN; DELTORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; OPIATE PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONJUNCTIVA EPITHELIUM; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT;

AMILORIDE; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CONJUNCTIVA; ENKEPHALIN, LEUCINE-2-ALANINE; EPITHELIAL CELLS; NALOXONE; OLIGOPEPTIDES; OPIOID PEPTIDES; ORGANIC ANION TRANSPORTERS; RABBITS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 63949085436     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9709-x     Document Type: Article

References (33)

1. K. Hosoya V. H. L. Lee K. J. Kim 2005 Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation Eur. J. Pharmaceut. Biopharmaceut. 60 227 240
2. V. Ganapathy S. Miyauchi 2003 Peptide transporters: Physiological function and potential for use as a drug delivery system Am. Pharmaceut. Rev. 6 14 18
3. T. Terada K. Inui 2004 Peptide transporters: structure, function, regulation and application for drug delivery Curr. Drug Metab. 5 85 94
4. M. Brandsch I. Knutter E. Bosse-Doenecke 2008 Pharmaceutical and pharmacological importance of peptide transporters J. Pharm. Pharmacol. 60 543 585
5. B. Hagenbuch P. J. Meier 2004 Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties Pflugers Arch.-Eur. J. Physiol. 447 653 665
6. E. M. Leslie R. G. Deeley S. P. Cole 2005 Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense Toxicol. Appl. Pharmacol. 204 216 237
7. S. Choudhuri C. D. Klaassen 2006 Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters Int. J. Toxicol. 25 231 259
8. -coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat Biochem. J. 375 17 22
9. S. Miyauchi E. Gopal S. V. Thakkar S. Ichikawa P. D. Prasad V. Ganapathy 2007 Differential modulation of sodium- and chloride- dependent opioid peptide transport system by small non-opioid peptides and free amino acids J. Pharmacol. Exp. Ther. 321 257 264
10. V. Ganapathy S. Miyauchi 2005 Transport systems for opioid peptides in mammalian tissues AAPS J. 7 E852 E856
11. K. Van Doren Y. Gluzman 1984 Efficient transformation of human fibroblasts by adenovirus-simian virus 40 recombinants Mol. Cell. Biol. 4 1653 1656
12. K. Araki Y. Ohashi T. Sasabe S. Kinoshita K. Hayashi X. Z. Yang Y. Hosaka S. Aizawa H. Handa 1993 Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector Invest. Ophthalmol. Vis. Sci. 34 2665 2671
13. M. Kasper 1992 Patterns of cytokeratins and vimentin in guinea pig and mouse eye tissue: evidence for regional variations in intermediate filament expression in limbal epithelium Acta Histochem. 93 319 332
14. V. Erspamer P. Melchiorri G. Falconieri-Erspamer L. Negri R. Corsi C. Severini D. Barra M. Simmaco G. Kreil 1989 Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for d opioid binding sites Proc. Natl. Acad. Sci. U. S. A. 86 5188 5192
15. L. H. Lazarus S. D. Bryant S. Salvadori M. Attila L. Sargent-Jones 1996 Opioid infidelity: Opioid peptides with dual high affinity for d and m receptors Trends Neurosci. 19 31 35
16. B. Gao B. Hagenbuch G. A. Kullak-Ublick D. Benke A. Aguzzi P. J. Meier 2000 Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier J. Pharmacol. Exp. Ther. 294 73 79
17. G. A. Kullak-Ublick M. G. Ismair B. Stieger L. Landmann R. Huber F. Pizzagalli K. Fattinger P. J. Meier B. Hagenbuch 2001 Organic anion transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Gastroenterology 120 525 533
18. T. Nozawa I. Tamai Y. Sai J. Nezu A. Tsuji 2003 Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin J. Pharm. Pharmacol. 55 1013 1020
19. C. Gui Y. Miao L. Thompson B. Wahlgren M. Mock B. Stieger B. Hagenbuch 2008 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3 Eur. J. Pharmacol. 584 57 65
20. +/glucose cotransporter J. Biol. Chem. 272 2110 2115
21. B. R. Stevens E. M. Wright 1987 Kinetics of the intestinal brush border proline (Imino) carrier J. Biol. Chem. 262 6546 6551
22. K. Ahmed P. G. Scholefield 1962 Biochemical studies on 1-aminocyclopentane carboxylic acid Can. J. Biochem. Physiol. 40 1101 1110
23. H. N. Christensen 1985 On the strategy of kinetic discrimination of amino acid transport systems J. Membr. Biol. 84 97 103
24. C. Tiruppathi V. Ganapathy F. H. Leibach 1990 Kinetic evidence for a common transporter for glycylsarcosine and phenylalanylprolylalanine in renal brush-border membrane vesicles J. Biol. Chem. 265 14870 14874
25. B. H. Rohde M. Zhu S. el Messiry G. C. Chiou 1993 Effects of some opiates and opioid peptide eyedrops on ocular melatonin regulation in rabbits Ophthalmic Res. 25 378 385
26. F. Drago G. Panissidi F. Bellomio A. Dal Bello E. Aguglia G. Gorgone 1985 Effects of opiates and opioids on intraocular pressure of rabbits and humans Clin. Exp. Pharmacol. Physiol. 12 107 113
27. D. Pavan-Langston 2008 Herpes zoster antivirals and pain management Ophthalmology 115 2 Suppl. S13 S20
28. N. C. Alonzo D. J. Carr 1999 Morphine reduces mortality in mice following ocular infection with HSV-1 Immunopharmacology 41 187 197
29. K. M. Hamalainen V. P. Ranta S. Auriola A. Urtti 2000 Enzymatic and permeation barrier of [D-Ala(2)]-Met-enkephalinamide in the anterior membranes of the albino rabbit eye Eur. J. Pharm. Sci. 9 265 270
30. I. S. Zagon J. W. Sassani E. R. Kane P. J. McLaughlin 1997 Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor Brain Res. 759 92 102
31. I. S. Zagon J. W. Sassani Y. Wu P. J. McLaughlin 1998 The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium Brain Res. 792 72 78
32. M. B. Miller B. L. Bassler 2001 Quorum sensing in bacteria Annu. Rev. Microbiol. 55 165 199
33. M. Fujiya M. W. Musch Y. Nakagawa S. Hu J. Alverdy Y. Kohgo O. Schneewind B. Jabri E. B. Chang 2007 The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter Cell Host Microbe 1 299 308