Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Biochemical Journal

Volumn 375, Issue 1, 2003, Pages 17-22

  Hu, Huankai ^a   Miyauchi, Seiji ^a   Bridges, Christy C ^a   Smith, Sylvia B ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Active transport; Dynorphins; Enkephalins; Opioid peptides

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS;

PLASMA MEMBRANES;

AMINO ACIDS;

OPIATE PEPTIDE; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN; CARRIER PROTEIN; CHLORIDE; DELTORPHIN II, ALA(2); DELTORPHIN II, ALA(2)-; OLIGOPEPTIDE; SODIUM;

ARTICLE; BINDING AFFINITY; CHLORIDE TRANSPORT; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMAL CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; SODIUM TRANSPORT; STATISTICAL SIGNIFICANCE; TRANSPORT KINETICS; ACTIVE TRANSPORT; CELL LINE; DRUG EFFECT; ENZYME SPECIFICITY; KINETICS; METABOLISM;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CHLORIDES; GENE PRODUCTS, TAT; HIV-1; HUMANS; KINETICS; MEMBRANE TRANSPORT PROTEINS; OLIGOPEPTIDES; OPIOID PEPTIDES; PIGMENT EPITHELIUM OF EYE; SODIUM; SUBSTRATE SPECIFICITY;

EID: 0141974951     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031059     Document Type: Article

References (26)

1. Gaynor, R. B. (1995) Regulation of HIV-1 gene expression by the transactivator protein Tat. Curr. Top. Microbiol. Immunol. 193, 51-77
2. Gallo, R. C. (1999) Tat as one key to HIV-induced immune pathogenesis and Tat toxoid as an important component of a vaccine. Proc. Natl. Acad. Sci. U.S.A. 96, 8324-8326
3. Hughes, B. A., Gallemore, R. P. and Miller, S. S. (1998) Transport mechanisms in retinal pigment epithelium. In The Retinal Pigment Epithelium: Current Aspects of Function and Disease (Marmor, M. F. and Wolfensberger, T. J., eds.), pp. 103-134, Oxford University Press, Oxford
4. c by HIV-1 transactivator protein TAT in the human retinal pigment epithelial cell line ARPE-19. Invest. Ophthalmol. Vis. Sci. 43, E-abstract 4565
5. 0, an amino acid transporter/retroviral receptor by HIV-1 Tat in RPE. Invest. Ophthalmol. Vis. Sci. 44, E-abstract 4616
6. Ganapathy, V., Miyauchi, S., Hu, H. and Smith, S. B. (2003) Regulation of expression of creatine transporter in ARPE-19 cells by HIV-1 Tat protein. Invest. Ophthalmol. Vis. Sci. 44, E-abstract 2275
7. Gao, B., Hagenbuch, B., Kullak-Ublick, G. A., Benke, D., Aguzzi, A. and Meier, P. J. (2000) Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J. Pharmacol. Exp. Ther. 294, 73-79
8. Banks, W. A. and Kastin, A. J. (1990) Peptide transport systems for opiates across the blood-brain barrier. Am. J. Physiol. 259, E1-E10
9. Banks, W. A., Kastin, A. J. and Michals, E. A. (1987) Tyr-MIF-1 and Met-enkephalin share a saturable blood-brain barrier transport system. Peptides 8, 899-903
10. Banks, W. A., Kastin, A. J., Fischman, A. J., Coy, D. H. and Strauss, S. L. (1986) Carrier-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am. J. Physiol. 251, E477-E482
11. 2.5]enkephalin into the central nervous system: saturation kinetics and specificity. J. Pharmacol. Exp. Ther. 280, 1235-1240
12. 2.5]enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers. J. Neurochem. 66, 1289-1299
13. Cattori, V., van Montfoort, J. E., Stieger, B., Landmann, L., Meijer, D. K., Winterhalter, K. H., Meier, P. J. and Hagenbuch, B. (2001) Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 443, 188-195
14. Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K., Meier, P. J. and Hagenbuch, B. (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterolgy 120, 525-533
15. Leibach, F. H. and Ganapathy, V. (1996) Peptide transporters in the intestine and the kidney. Annu. Rev. Nutr. 16, 99-119
16. + symporters. J. Membr. Biol. 154, 197-203
17. Inui, K. and Terada, T. (1999) Dipeptide transporters. Pharmaceut. Biotechnol. 12, 269-288
18. Ganapathy, V. and Miyauchi, S. (2003) Am. Pharmaceut. Rev. 6, 14-18
19. Hauser, M., Donhardt, A. M., Barnes, D., Naider, F. and Becker, J. M. (2000) Enkephalins are transported by a novel eukaryotic peptide uptake system. J. Biol. Chem. 275, 3037-3041
20. Ryder, S. W. and Eng, J. (1982) Radioimmunoassay of leucine-enkephalin like substance in human and canine plasma. J. Clin. Endocrinol. Metab. 52, 367-369
21. Hambrook, J. M., Morgan, B. A., Rance, M. J. and Smith, C. F. C. (1976) Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates. Nature 262, 782-783
22. Roda, L. G., De Marco, V. and Possenti, R. (1983) Stability of peripheral enkephalins. In Degradation of Endogenous Opioid (Ehrenpreis, S. and Sicuteri, F., eds.), pp. 25-42, Raven Press, New York
23. Roda, L. G., Roscetti, G., Possenti, R., Venturelli, F. and Vita, F. (1986) Control mechanisms in the enzyme hydrolysis of adrenal-released enkephalins. In Enkephalins and Endorphins. Stress and the Immune System (Plotnikoff, N. P., Faith, R. E., Murgo, A. J. and Good, R. A., eds.), pp. 17-33. Plenum Press, New York
24. Chaturvedi, K., Christoffers, K. H., Singh, K. and Howells, R. D. (2000) Structure and regulation of opioid receptors. Biopolymers 55, 334-346
25. Kieffer, B. L. and Gaveriaux-Ruff, C. (2002) Exploring the opioid system by gene knockout. Prog. Neurobiol. 66, 285-306
26. Zagon, I. S., Verderame, M. F. and McLaughlin, P. J. (2002) The biology of the opioid growth factor receptor (OGFr). Brain Res. Rev. 38, 351-376