Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 1, 2007, Pages 257-264

  Miyauchi, Seiji ^a   Gopal, Elangovan ^a   Thakkar, Santosh V ^a   Ichikawa, Satoshi ^b   Prasad, Puttur D ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DELTORPHIN 2; ESTER; ETHYL ESTER; GLYCYLGLYCYLISOLEUCINE; LYSINE; METHYL ESTER; NEUROPEPTIDE; OPIATE PEPTIDE; SODIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; NEUROMODULATION; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; TRANSPORT KINETICS;

AMINO ACIDS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, NONESTERIFIED; HUMANS; KINETICS; MOLECULAR CONFORMATION; OLIGOPEPTIDES; OPIOID PEPTIDES; SODIUM;

EID: 33947360597     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.116806     Document Type: Article

References (34)

1. Akil H, Watson SJ, Young E, Lewis ME, Khachaturian H, and Walker JM (1984) Endogenous opioids: biology and function. Annu Rev Neurosci 7:223-255.
2. Banks WA and Kastin AJ (1990) Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol 259:E1-E10.
3. Bodnar RJ and Hadjimarkou MM (2003) Endogenous opiates and behavior: 2002. Peptides 24:1241-1302.
4. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, and Hagenbuch B (2001) Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflueg Arch Eur J Physiol 443:188-195.
5. Chen C and Pollack GM (1998) Altered disposition and antinociception of [D-penicillamine(2,5)] enkephalin in mdr1a-gene-deficient mice. J Pharmacol Exp Ther 287:545-552.
6. Chen C and Pollack GM (1999) Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation. Pharm Res (NY) 16:296-301.
7. Daniel H and Kottra G (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflueg Arch Eur J Physiol 447:610-618.
8. De Luca A and Coupar IM (1996) Insights into opioid action in the intestinal tract. Pharmacol Ther 69:103-115.
9. Fiori A, Cardelli P, Negri L, Savi MR, Strom R, and Erspamer V (1997) Deltorphin transport across the blood-brain barrier. Proc Natl Acad Sci USA 94:9469-9474.
10. Ganapathy V and Miyauchi S (2003) Peptide transporters: physiological function and potential for use as a drug delivery system. Am Pharm Rev 6:14-18.
11. Ganapathy V and Miyauchi S (2005) Transport systems for opioid peptides in mammalian tissues. AAPS J 7:E852-E856.
12. Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, and Meier PJ (2000) Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 294:73-79.
13. 5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems. J Pharmacol Exp Ther 311:1203-1210.
14. Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, and Brouwer KL (2005) Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin. Drug Metab Dispos 33:287-293.
15. - system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. Biochem J 375:17-22.
16. King M, Su W, Chang A, Zuckerman A, and Pasternak GW (2001) Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci 4:268-274.
17. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, and Hagenbuch B (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with 3 other OATPs of human liver. Gastroenterology 120:525-533.
18. Lane RM, Kivipelto M, and Greig NH (2004) Acetylcholinesterase and its inhibition in Alzheimer disease. Clin Neuropharmacol 27:141-149.
19. Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, and Kim RB (2005) Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem 280:9610-9617.
20. - neurotransmitter transporters. J Neurochem 71:1785-1803.
21. 5]-enkephalin. J Pharm Pharmacol 55:1013-1020.
22. Okada Y, Tsuda Y, Bryant SD, and Lazarus LH (2002) Endomorphins and related opioid peptides. Vitam Horm 65:257-279.
23. Oude Elferink RPJ and Zadina J (2001) MDR1 P-glycoprotein transports endogenous opioid peptides. Peptides 22:2015-2020.
24. Roques BP (2000) Novel approaches to targeting neuropeptide systems. Trends Pharmacol Sci 21:475-483.
25. Roques BP and Fournie-Zaluski MC (1986) Opioid peptides: molecular pharmacology, biosynthesis and analysis. NIDA Research Monograph Series 70:128-154.
26. Sarkadi B, Muller M, Homolya L, Hollo Z, Seprodi J, Germann UA, Gottesman MM, Price EM, and Boucher RC (1994) Interaction of bioactive hydrophobic peptides with the human multidrug transporter. FASEB J 8:766-770.
27. Shen H, Smith DE, Keep RF, and Brosius FC 3rd (2004) Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol Pharmacol 1:248-256.
28. Smriga M and Torii K (2003) L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci USA 100:15370-15375.
29. Somogyvari-Vigh A, Kastin AJ, Liao J, Zadina JE, and Pan W (2004) Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells. Exp Brain Res 156:224-230.
30. Sundler F, Bjartell A, Bottcher G, Ekblad E, and Hakanson R (1987) Localization of enkephalins and other endogenous opioids in the digestive tract. Gastroenterol Clin Biol 11:14B-26B.
31. Teuscher NS, Keep RF, and Smith DE (2001) PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm Res (NY) 18:807-813.
32. Thompson SJ, Koszdin K, and Bernards CM (2000) Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein. Anesthesiology 92:1392-1399.
33. Waldhoer M, Bartlett SE, and Whistler JL (2004) Opioid receptors. Annu Rev Biochem 73:953-990.
34. Wang H, Fei YJ, Ganapathy V, and Leibach FH (1998) Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain. Am J Physiol 275:C967-C975.