메뉴 건너뛰기




Volumn 50, Issue 4, 2009, Pages 824-831

Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models

Author keywords

Electroshock model; Nonepileptic animal; Pentylenetetrazole; Pilocarpine

Indexed keywords

PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; PILOCARPINE; VALPROIC ACID;

EID: 63849285232     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01797.x     Document Type: Article
Times cited : (60)

References (52)
  • 1
    • 0034112172 scopus 로고    scopus 로고
    • Kindling induced by pentylenetetrazole in rats is not directly associated with changes in the expression of NMDA or benzodiazepine receptors
    • Atack JR, Cook SM, Hutson PH, File SE 2000) Kindling induced by pentylenetetrazole in rats is not directly associated with changes in the expression of NMDA or benzodiazepine receptors. Pharmacol Biochem Behav 65 : 743 750.
    • (2000) Pharmacol Biochem Behav , vol.65 , pp. 743-750
    • Atack, J.R.1    Cook, S.M.2    Hutson, P.H.3    File, S.E.4
  • 2
    • 0031957398 scopus 로고    scopus 로고
    • Advances in the medical treatment of epilepsy
    • Bazil CW, Pedley TA 1998) Advances in the medical treatment of epilepsy. Annu Rev Med 49 : 135 162.
    • (1998) Annu Rev Med , vol.49 , pp. 135-162
    • Bazil, C.W.1    Pedley, T.A.2
  • 3
    • 0019490885 scopus 로고
    • Effect of midbrain and pontine tegmental lesions on the maximal electroshock seizure pattern in rats
    • Browning RA, Turner FJ, Simonton RL, Bundman MC 1981) Effect of midbrain and pontine tegmental lesions on the maximal electroshock seizure pattern in rats. Epilepsia 22 : 583 594.
    • (1981) Epilepsia , vol.22 , pp. 583-594
    • Browning, R.A.1    Turner, F.J.2    Simonton, R.L.3    Bundman, M.C.4
  • 4
    • 0021885199 scopus 로고
    • Role of the brain-stem reticular formation in tonic-clonic seizures: Lesion and pharmacological studies
    • Browning RA 1985) Role of the brain-stem reticular formation in tonic-clonic seizures: lesion and pharmacological studies. Fed Proc 44 : 2425 2431.
    • (1985) Fed Proc , vol.44 , pp. 2425-2431
    • Browning, R.A.1
  • 5
    • 0021836485 scopus 로고
    • Effect of midbrain and pontine tegmental lesions on audiogenic seizures in genetically epilepsy-prone rats
    • Browning RA, Nelson DK, Mogharreban N, Jobe PC, Laird HE 2nd. 1985) Effect of midbrain and pontine tegmental lesions on audiogenic seizures in genetically epilepsy-prone rats. Epilepsia 26 : 175 183.
    • (1985) Epilepsia , vol.26 , pp. 175-183
    • Browning, R.A.1    Nelson, D.K.2    Mogharreban, N.3    Jobe, P.C.4    Laird II, H.E.5
  • 6
    • 0022889277 scopus 로고
    • Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections
    • Browning RA, Nelson DK 1986) Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections. Exp Neurol 93 : 546 556.
    • (1986) Exp Neurol , vol.93 , pp. 546-556
    • Browning, R.A.1    Nelson, D.K.2
  • 7
    • 0025298910 scopus 로고
    • Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): Differences in threshold and pattern
    • Browning RA, Wang C, Lanker ML, Jobe PC 1990) Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern. Epilepsy Res 6 : 1 11.
    • (1990) Epilepsy Res , vol.6 , pp. 1-11
    • Browning, R.A.1    Wang, C.2    Lanker, M.L.3    Jobe, P.C.4
  • 8
    • 1542315525 scopus 로고    scopus 로고
    • Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice
    • Carnevalli LS, Pereira CM, Longo BM, Jaqueta CB, Avedissian M, Mello LE, Castilho BA 2004) Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice. Neurosci Lett 357 : 191 194.
    • (2004) Neurosci Lett , vol.357 , pp. 191-194
    • Carnevalli, L.S.1    Pereira, C.M.2    Longo, B.M.3    Jaqueta, C.B.4    Avedissian, M.5    Mello, L.E.6    Castilho, B.A.7
  • 9
    • 13444273026 scopus 로고    scopus 로고
    • Pilocarpine prevents age-related spatial learning impairments in rats
    • De Mello N, Souza-Junior IQ, Carobrez AP 2005) Pilocarpine prevents age-related spatial learning impairments in rats. Behav Brain Res 158 : 263 268.
    • (2005) Behav Brain Res , vol.158 , pp. 263-268
    • De Mello, N.1    Souza-Junior, I.Q.2    Carobrez, A.P.3
  • 10
    • 0030711507 scopus 로고    scopus 로고
    • Basic mechanisms of epilepsy: Targets for therapeutic intervention
    • Dichter MA 1997) Basic mechanisms of epilepsy: targets for therapeutic intervention. Epilepsia 38 (Suppl. 9 S2 S6.
    • (1997) Epilepsia , vol.38 , Issue.SUPPL. 9
    • Dichter, M.A.1
  • 11
    • 0030848694 scopus 로고    scopus 로고
    • Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: Comparison to electroshock and pentylenetetrazol seizure models
    • Eells JB, Clough RW, Browning RA, Jobe PC 1997) Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models. Neurosci Lett 233 : 21 24.
    • (1997) Neurosci Lett , vol.233 , pp. 21-24
    • Eells, J.B.1    Clough, R.W.2    Browning, R.A.3    Jobe, P.C.4
  • 12
    • 0345549416 scopus 로고    scopus 로고
    • Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats
    • Eells JB, Clough RW, Browning RA, Jobe PC 2004) Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. Neuroscience 123 : 279 292.
    • (2004) Neuroscience , vol.123 , pp. 279-292
    • Eells, J.B.1    Clough, R.W.2    Browning, R.A.3    Jobe, P.C.4
  • 13
    • 34447629895 scopus 로고    scopus 로고
    • Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus
    • Kirschstein T, Bauer M, Muller L, Ruschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H 2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci 27 : 7696 7704.
    • (2007) J Neurosci , vol.27 , pp. 7696-7704
    • Kirschstein, T.1    Bauer, M.2    Muller, L.3    Ruschenschmidt, C.4    Reitze, M.5    Becker, A.J.6    Schoch, S.7    Beck, H.8
  • 14
    • 20544473013 scopus 로고    scopus 로고
    • Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats
    • Kitano Y, Komiyama C, Makino M, Takasuna K, Takazawa A, Sakurada S 2005) Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats. Epilepsia 46 : 811 818.
    • (2005) Epilepsia , vol.46 , pp. 811-818
    • Kitano, Y.1    Komiyama, C.2    Makino, M.3    Takasuna, K.4    Takazawa, A.5    Sakurada, S.6
  • 15
    • 0028836283 scopus 로고
    • Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats
    • Leite JP, Cavalheiro EA 1995) Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. Epilepsy Res 20 : 93 104.
    • (1995) Epilepsy Res , vol.20 , pp. 93-104
    • Leite, J.P.1    Cavalheiro, E.A.2
  • 16
    • 0036337766 scopus 로고    scopus 로고
    • Electrophysiologic abnormalities of the hippocampus in the pilocarpine/cycloheximide model of chronic spontaneous seizures
    • Longo BM, Sanabria ER, Gabriel S, Mello LE 2002) Electrophysiologic abnormalities of the hippocampus in the pilocarpine/cycloheximide model of chronic spontaneous seizures. Epilepsia 43 (Suppl. 5 203 208.
    • (2002) Epilepsia , vol.43 , Issue.SUPPL. 5 , pp. 203-208
    • Longo, B.M.1    Sanabria, E.R.2    Gabriel, S.3    Mello, L.E.4
  • 17
    • 0023897574 scopus 로고
    • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
    • Loscher W, Schmidt D 1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2 : 145 181.
    • (1988) Epilepsy Res , vol.2 , pp. 145-181
    • Loscher, W.1    Schmidt, D.2
  • 18
    • 0025982093 scopus 로고
    • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models
    • Loscher W, Fassbender CP, Nolting B 1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res 8 : 79 94.
    • (1991) Epilepsy Res , vol.8 , pp. 79-94
    • Loscher, W.1    Fassbender, C.P.2    Nolting, B.3
  • 19
    • 0028220347 scopus 로고
    • Strategies in antiepileptic drug development: Is rational drug design superior to random screening and structural variation?
    • Loscher W, Schmidt D 1994) Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 17 : 95 134.
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Loscher, W.1    Schmidt, D.2
  • 20
    • 0343990077 scopus 로고    scopus 로고
    • Animal models of intractable epilepsy
    • Loscher W 1997) Animal models of intractable epilepsy. Prog Neurobiol 53 : 239 258.
    • (1997) Prog Neurobiol , vol.53 , pp. 239-258
    • Loscher, W.1
  • 21
    • 0345019797 scopus 로고    scopus 로고
    • New visions in the pharmacology of anticonvulsion
    • Loscher W 1998) New visions in the pharmacology of anticonvulsion. Eur J Pharmacol 342 : 1 13.
    • (1998) Eur J Pharmacol , vol.342 , pp. 1-13
    • Loscher, W.1
  • 22
    • 0036109602 scopus 로고    scopus 로고
    • Animal models of drug-resistant epilepsy
    • discussion
    • Loscher W 2002a) Animal models of drug-resistant epilepsy. Novartis Found Symp 243 : 149 159 discussion 159 166.
    • (2002) Novartis Found Symp , vol.243 , pp. 149-159
    • Loscher, W.1
  • 23
    • 0036347772 scopus 로고    scopus 로고
    • Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy
    • Loscher W 2002b) Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res 50 : 105 123.
    • (2002) Epilepsy Res , vol.50 , pp. 105-123
    • Loscher, W.1
  • 24
    • 0036499726 scopus 로고    scopus 로고
    • Current status and future directions in the pharmacotherapy of epilepsy
    • Loscher W 2002c) Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol Sci 23 : 113 118.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 113-118
    • Loscher, W.1
  • 25
    • 0036128985 scopus 로고    scopus 로고
    • Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
    • Loscher W, Potschka H 2002) Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 301 : 7 14.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 7-14
    • Loscher, W.1    Potschka, H.2
  • 26
    • 0036342414 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs
    • Loscher W, Schmidt D 2002) New horizons in the development of antiepileptic drugs. Epilepsy Res 50 : 3 16.
    • (2002) Epilepsy Res , vol.50 , pp. 3-16
    • Loscher, W.1    Schmidt, D.2
  • 27
    • 8444232772 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs: The search for new targets
    • Loscher W, Schmidt D 2004) New horizons in the development of antiepileptic drugs: the search for new targets. Epilepsy Res 60 : 77 159.
    • (2004) Epilepsy Res , vol.60 , pp. 77-159
    • Loscher, W.1    Schmidt, D.2
  • 28
    • 5344234533 scopus 로고    scopus 로고
    • Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures
    • Loscher W, Potschka H, Rieck S, Tipold A, Rundfeldt C 2004) Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia 45 : 1228 1239.
    • (2004) Epilepsia , vol.45 , pp. 1228-1239
    • Loscher, W.1    Potschka, H.2    Rieck, S.3    Tipold, A.4    Rundfeldt, C.5
  • 29
    • 34250208753 scopus 로고    scopus 로고
    • Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in mice
    • Luszczki JJ, Swiader MJ, Swiader K, Paruszewski R, Turski WA, Czuczwar SJ 2007) Characterization of the anticonvulsant profile of isonicotinic acid benzylamide in various experimental seizure models in mice. Neurosci Lett 421 : 87 90.
    • (2007) Neurosci Lett , vol.421 , pp. 87-90
    • Luszczki, J.J.1    Swiader, M.J.2    Swiader, K.3    Paruszewski, R.4    Turski, W.A.5    Czuczwar, S.J.6
  • 30
    • 0026630341 scopus 로고
    • The neurobiological basis of epilepsy
    • McNamara JO 1992) The neurobiological basis of epilepsy. Trends Neurosci 15 : 357 359.
    • (1992) Trends Neurosci , vol.15 , pp. 357-359
    • McNamara, J.O.1
  • 31
    • 0028179659 scopus 로고
    • Cellular and molecular basis of epilepsy
    • McNamara JO 1994) Cellular and molecular basis of epilepsy. J Neurosci 14 : 3413 3425.
    • (1994) J Neurosci , vol.14 , pp. 3413-3425
    • McNamara, J.O.1
  • 32
    • 0030664670 scopus 로고    scopus 로고
    • Identification and preclinical testing of novel antiepileptic compounds
    • Meldrum BS 1997) Identification and preclinical testing of novel antiepileptic compounds. Epilepsia 38 (Suppl. 9 S7 S15.
    • (1997) Epilepsia , vol.38 , Issue.SUPPL. 9
    • Meldrum, B.S.1
  • 34
    • 0036348414 scopus 로고    scopus 로고
    • Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs
    • Meldrum B 2002) Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs. Epilepsy Res 50 : 33 40.
    • (2002) Epilepsy Res , vol.50 , pp. 33-40
    • Meldrum, B.1
  • 35
    • 0027143716 scopus 로고
    • Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: Cell loss and mossy fiber sprouting
    • Mello LE, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM 1993) Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34 : 985 995.
    • (1993) Epilepsia , vol.34 , pp. 985-995
    • Mello, L.E.1    Cavalheiro, E.A.2    Tan, A.M.3    Kupfer, W.R.4    Pretorius, J.K.5    Babb, T.L.6    Finch, D.M.7
  • 36
    • 44949210221 scopus 로고    scopus 로고
    • When should a resection sparing mesial structures be considered for temporal lobe epilepsy?
    • Mintzer S, Sperling MR 2008) When should a resection sparing mesial structures be considered for temporal lobe epilepsy? Epilepsy Behav 13 : 7 11.
    • (2008) Epilepsy Behav , vol.13 , pp. 7-11
    • Mintzer, S.1    Sperling, M.R.2
  • 37
    • 2942574539 scopus 로고    scopus 로고
    • Kindling and status epilepticus models of epilepsy: Rewiring the brain
    • Morimoto K, Fahnestock M, Racine RJ 2004) Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 73 : 1 60.
    • (2004) Prog Neurobiol , vol.73 , pp. 1-60
    • Morimoto, K.1    Fahnestock, M.2    Racine, R.J.3
  • 38
    • 0015306389 scopus 로고
    • Modification of seizures activity by electrical stimulation: II Motor seizure
    • Racine RJ 1972) Modification of seizures activity by electrical stimulation: II Motor seizure. Electroencephalogr Clin Neurophysiol 32.
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32
    • Racine, R.J.1
  • 39
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski MA, Loscher W 2004a) The neurobiology of antiepileptic drugs. Nat Rev Neurosci 5 : 553 564.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 553-564
    • Rogawski, M.A.1    Loscher, W.2
  • 40
    • 3142774111 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
    • Rogawski MA, Loscher W 2004b) The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 10 : 685 692.
    • (2004) Nat Med , vol.10 , pp. 685-692
    • Rogawski, M.A.1    Loscher, W.2
  • 41
    • 0037449406 scopus 로고    scopus 로고
    • Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentylenetetrazole and pilocarpine
    • Scarlatelli-Lima AV, Magalhaes LH, Doretto MC, Moraes MF 2003) Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentylenetetrazole and pilocarpine. Brain Res 960 : 184 189.
    • (2003) Brain Res , vol.960 , pp. 184-189
    • Scarlatelli-Lima, A.V.1    Magalhaes, L.H.2    Doretto, M.C.3    Moraes, M.F.4
  • 42
    • 0029014835 scopus 로고
    • Predicting long-term outcome of childhood epilepsy in Nova Scotia, Canada, and Turku, Finland. Validation of a simple scoring system
    • Sillanpaa M, Camfield P, Camfield C 1995) Predicting long-term outcome of childhood epilepsy in Nova Scotia, Canada, and Turku, Finland. Validation of a simple scoring system. Arch Neurol 52 : 589 592.
    • (1995) Arch Neurol , vol.52 , pp. 589-592
    • Sillanpaa, M.1    Camfield, P.2    Camfield, C.3
  • 43
    • 2942744683 scopus 로고    scopus 로고
    • Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models
    • Sills GJ, Butler E, Thompson GG, Brodie MJ 2004) Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure 13 : 287 295.
    • (2004) Seizure , vol.13 , pp. 287-295
    • Sills, G.J.1    Butler, E.2    Thompson, G.G.3    Brodie, M.J.4
  • 44
    • 0028359677 scopus 로고
    • The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy
    • Sloviter RS 1994a) The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 35 : 640 654.
    • (1994) Ann Neurol , vol.35 , pp. 640-654
    • Sloviter, R.S.1
  • 45
    • 0028131909 scopus 로고
    • On the relationship between neuropathology and pathophysiology in the epileptic hippocampus of humans and experimental animals
    • Sloviter RS 1994b) On the relationship between neuropathology and pathophysiology in the epileptic hippocampus of humans and experimental animals. Hippocampus 4 : 250 253.
    • (1994) Hippocampus , vol.4 , pp. 250-253
    • Sloviter, R.S.1
  • 47
    • 0347364701 scopus 로고    scopus 로고
    • Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: Summary of the NIH/NINDS/AES models II workshop
    • Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS 2003) Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia 44 : 1472 1478.
    • (2003) Epilepsia , vol.44 , pp. 1472-1478
    • Stables, J.P.1    Bertram, E.2    Dudek, F.E.3    Holmes, G.4    Mathern, G.5    Pitkanen, A.6    White, H.S.7
  • 48
    • 0020545095 scopus 로고
    • Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
    • Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L 1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9 : 315 335.
    • (1983) Behav Brain Res , vol.9 , pp. 315-335
    • Turski, W.A.1    Cavalheiro, E.A.2    Schwarz, M.3    Czuczwar, S.J.4    Kleinrok, Z.5    Turski, L.6
  • 49
    • 0021684071 scopus 로고
    • Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
    • Turski WA, Cavalheiro EA, Bortolotto ZA, Mello LM, Schwarz M, Turski L 1984) Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res 321 : 237 253.
    • (1984) Brain Res , vol.321 , pp. 237-253
    • Turski, W.A.1    Cavalheiro, E.A.2    Bortolotto, Z.A.3    Mello, L.M.4    Schwarz, M.5    Turski, L.6
  • 50
    • 0025300505 scopus 로고
    • Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. the effects of 2-amino-7-phosphonoheptanoate
    • Velisek L, Kusa R, Kulovana M, Mares P 1990) Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. Life Sci 46 : 1349 1357.
    • (1990) Life Sci , vol.46 , pp. 1349-1357
    • Velisek, L.1    Kusa, R.2    Kulovana, M.3    Mares, P.4
  • 51
    • 0028826039 scopus 로고
    • Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. the action of kynurenic acid and glutamic acid diethylester
    • Velisek L, Roztocilova L, Kusa R, Mares P 1995) Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. Brain Res Bull 38 : 525 529.
    • (1995) Brain Res Bull , vol.38 , pp. 525-529
    • Velisek, L.1    Roztocilova, L.2    Kusa, R.3    Mares, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.