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4, and concentrated under vacuum to yield pure product 4a.
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4, and concentrated under vacuum to yield pure product 4a.
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38
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63849340020
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2-Amino-3-cyano-4H-chromen-4-yl) Phosphonic Acid Diethyl Ester (4a, Table 1, Entry 1) White solid; mp 140-142 °C. IR (KBr, v max, 3349, 3167, 2189, 1648, 1422, 1233, 1030 cm-1. 1H NMR (500 MHz, DMSO-d6, δ, 1.09 (t, 3 H, J, 6.9 Hz, 1.14 (t, 3 H, J, 6.85 Hz, 3.87 (m, 4 H, 4.04 (d, 1 H, 2JPH, 17.6 Hz, 6.97 (d, 1 H, J, 8.4 Hz, 7.10 (t, 1 H, J, 6.85 Hz, 7.14 (br s, 2 H, NH2, D 2O exchangeable, 7.22 (m, 2 H, 13C NMR (75 MHz, DMSO-d6, δ, 16.1, 16.2, 34.5 (d, 1 Jcp, 144.0 Hz, 47.3 (d, 2JCP, 7.5 Hz, 62.1 (d, 2JCP, 7.5 Hz, 62.2 (d, 2JCP, 6.75 Hz, 115.9, 117.7, 120.1, 124.2, 128.8, 129.4, 149.9, 162.6.31P NMR 202.5 MHz, DMSO-d6, δ
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4P: C, 43.43; H, 4.17; N, 7.24. Found: C, 43.38; H, 4.11; N, 7.20.
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