Solvent-free NbCl5 catalyzed condensation of 1,3-dicarbonyl compounds and aldehydes: a facile synthesis of trisubstituted alkenes

Tetrahedron Letters

Volumn 50, Issue 21, 2009, Pages 2470-2473

  Yadav, J S ^a   Bhunia, Dinesh C ^a   Singh, Vinay K ^a   Srihari, P ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DICARBONYL DERIVATIVE; 1,3 DIKETONE; ALDEHYDE DERIVATIVE; ALKENE DERIVATIVE; BETA OXOCARBOXYLIC ACID ESTER; CARBONYL DERIVATIVE; CHLORIDE; ESTER DERIVATIVE; LEWIS ACID; NIOBIUM PENTACHLORIDE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; KNOEVENAGEL CONDENSATION; POLYMERIZATION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 63749085583     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.03.015     Document Type: Article

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44. 3 solution and the product was extracted with ethylacetate. The product was purified by column chromatography using EtOAc/Hexane as an eluent. As per the comment raised by the referee, a reaction was attempted on 10 mmol scale. Compound 5a was prepared on 10 mmol scale in 1.5 h with 83% yield using 20 mol % catalyst.
45. 3Na, 241.0840. Found 241.0833.