Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: A report of 89 cases

Modern Pathology

Volumn 18, Issue 7, 2005, Pages 917-923

  Velazquez, Elsa F ^a   Soskin, Ana ^b   Bock, Adelaida ^b   Codas, Ricardo ^b   Cai, Guoping ^a   Barreto, Jose E ^b   Cubilla, Antonio L ^b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSIDAD NACIONAL DE ASUNCIÓN   (Paraguay)

Author keywords

Penile carcinoma; Squamous intraepithelial lesion; Squamous metaplasia; Urethral epithelium

Indexed keywords

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; DISEASE COURSE; DYSPLASIA; HISTOLOGY; HUMAN; HUMAN CELL; HYPERKERATOSIS; MALE; PENIS AMPUTATION; PENIS CARCINOMA; PRECANCER; PRIORITY JOURNAL; SKIN DEFECT; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL METAPLASIA; TUMOR VOLUME; URETHRA; URETHRA TUMOR; VERRUCOUS CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; EPITHELIUM; HUMANS; HYPERPLASIA; KERATOSIS; LICHEN SCLEROSUS ET ATROPHICUS; MALE; METAPLASIA; MIDDLE AGED; NEOPLASM INVASIVENESS; PENILE NEOPLASMS; PRECANCEROUS CONDITIONS; URETHRA; URETHRAL NEOPLASMS;

EID: 23044470676     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800371     Document Type: Article

References (21)

1. Barreto JE, Caballero C, Cubilla AL. Penis. In: Sternberg S (ed). Histology for Pathologists, 2nd edn. Lippincott Williams & Wilkins: Philadelphia, PA, 1997, pp 1039-1047.
2. Herbat P. The urethra. In: Lea and Febiger (eds). Urological Pathology. Vol. I. Philadelphia, PA, 1952, pp 20-26.
3. Kurzrock EA, Baskin LS, Cunha GR. Ontogeny of the male urethra: theory of endodermal differentiation. Differentiation 1999;64:115-122.
4. Young RH, Srigley JR, Amin MB, et al. Tumors of the prostate gland, seminal vesicles, male urethra and penis, Atlas of Tumor Pathology Fascicle 3rd series ed. Armed Forces Institute of Pathology: Washington, DC, 2000.
5. Grussendorf-Conen EI, Deutz FJ, de Villiers EM. Detection of human papillomavirus-6 in primary carcinoma of the urethra in men. Cancer 1987;60: 1832-1835.
6. Wiener JS, Liu ET, Walther PJ. Oncogenic human papillomavirus type 16 is associated with squamous cell cancer in male urethra. Cancer Res 1992;52: 5018-5023.
7. Velazquez EF, Soskin A, Bock A, et al. Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol 2004;28:384-389.
8. Cubilla AL, Ayala MT, Barreto JE, et al. Surface adenosquamous carcinoma of the penis. A report of three cases. Am J Surg Pathol 1996;20:156-160.
9. Fang AW, Whittaker MA, Theaker JM. Mucinous metaplasia of the penis. Histopathology 2002;40: 177-179.
10. Val-Bernal JF, Hernandez-Nieto E. Benign mucinous metaplasia of the penis. A lesion resembling extramammary Paget's disease. J Cutan Pathol 2000;27:76-79.
11. Cubilla AL, Piris A, Pfannl R, et al. Anatomical levels: Important landmarks in penectomy specimens: a detailed anatomic and histologic study based on examination of 44 Cases. Am J Surg Pathol 2001;25: 1091-1094.
12. Cubilla AL, Meijer CJ, Young RH. Morphological features of epithelial abnormalities and precancerous lesions of the penis. Scand J Urol Nephrol Suppl 2000;205:215-219.
13. Cubilla AL, Velazquez EF, Young RH. Epithelial lesions associated with invasive penile squamous cell carcinoma: a pathologic study of 288 cases. Int J Surg Pathol 2004;12:351-364.
14. Cupp MR, Malek RS, Goellner JR, et al. Detection of human papillomavirus DNA in primary squamous cell carcinoma of male urethra. Urology 1996;48:551-555.
15. Dalbagni G, Zhang ZF, Lacombe L, et al. Male urethral carcinoma: analysis of treatment outcome. Urology 1999;53:1126-1132.
16. Davis JW, Schellhammer PF, Schlossberg SM. Conservative surgical therapy for penile and urethral carcinoma. Urology 1999;53:386-392.
17. Barbagli G, Lazzeri M, Palminteri E, et al. Lichen sclerosis of male genitalia involving anterior urethra. Lancet 1999;354:429.
18. Velazquez EF, Cubilla AL. Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol 2003;27:1448-1453.
19. Bailey DM, Foley SJ, McFarlane JP, et al. Histological changes associated with long term urethral stents. Br J Urol 1998;81:745-749.
20. Russell GA, Crowley T, Dalrymple JO. Squamous metaplasia in the penile urethra due to estrogen therapy. Br J Urol 1992;69:282-285.
21. Cohen RJ, Garrett K, Golding JL, et al. Epithelial differentiation of the lower urinary tract with recognition of the minor prostatic glands. Hum Pathol 2002; 33:905-909.