Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in rats

Journal of Ethnopharmacology

Volumn 122, Issue 3, 2009, Pages 561-566

  Tadros, Mariane G ^a   Mohamed, Mohamed R ^b   Youssef, Amal M ^c   Sabry, Gilane M ^b   Sabry, Nagwa A ^a   Khalifa, Amani E ^a  

^a Ain Shams University   (Egypt)

^b Ain Shams University   (Egypt)

^c Suez Canal University   (Egypt)

Author keywords

Antiamnestic; Apoptosis; Hyperforin; Prepulse inhibition (PPI); St. John's wort

Indexed keywords

HYPERFORIN; HYPERICUM PERFORATUM EXTRACT;

ACOUSTIC REFLEX; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DNA FRAGMENTATION; DNA ISOLATION; DRUG ACTIVITY; DRUG MECHANISM; ELECTROPHORESIS; GEL ELECTROPHORESIS; HYPERICUM PERFORATUM; MALE; MEMORY DISORDER; NEUROLOGIC DISEASE; NONHUMAN; PREPULSE INHIBITION; RAT; STARTLE REFLEX;

AMNESIA; ANIMALS; APOPTOSIS; BICYCLO COMPOUNDS; CENTRAL NERVOUS SYSTEM AGENTS; CEREBRAL CORTEX; CHOLINERGIC ANTAGONISTS; DNA FRAGMENTATION; HYPERICUM; MALE; PHLOROGLUCINOL; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RATS; RATS, WISTAR; SCOPOLAMINE; SENSORY GATING; STARTLE REACTION; TERPENES;

ANIMALIA; HYPERICUM PERFORATUM; RATTUS;

EID: 63649152540     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.01.009     Document Type: Article

References (34)

1. Adler L.E., Olincy A., Waldo M., Harris J.G., Griffith J., Stevens K., Flach K., Nagamoto H., Bickford P., Leonard S., and Freedman R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophrenia Bulletin 24 (1998) 189-202
2. Alsene K.M., Carasso B.S., Connors E.E., and Bakshi V.P. Disruption of prepulse inhibition after stimulation of central but not peripheral alpha-1 adrenergic receptors. Neuropsychopharmacology 31 (2006) 2150-2161
3. Auclair A.L., Galinier A., Besnard J., Newman-Tancredi A., and Depoortere R. Putative antipsychotics with pronounced agonism at Serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats. Psychopharmacology 193 (2007) 45-54
4. Babar E., Ozgunen T., Melikov E., and Polat S. The median raphe nucleus lesion attenuates amnesic effects of ketamine on short-term memory in rats. Journal of Islamic Academy of Sciences 7 (1994) 241-246
5. Coskun I., Tayfun Uzaby I., Ozturk N., and Ozturk Y. Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats. Fundamental and Clinical Pharmacology 20 (2006) 481-488
6. de Jong I.E., and van den Buuse M. SCH 23390 in the prefrontal cortex enhances the effect of apomorphine on prepulse inhibition of rats. Neuropharmacology 51 (2006) 438-446
7. Di Carlo G., Borrelli F., Ernst E., and Izzo A.A. St. John's wort: Prozac from the plant kingdom. Trends in Pharmacological Sciences 22 (2001) 292-297
8. Dona M., Dell'Aica I., Pezzato E., Sartor L., Calabrese F., Barbera M.D., Donella-Deana A., Appendino G., Borsarini A., Caniato R., and Garbisa S. Hyperforin inhibits cancer invasion and metastasis. Cancer Research 64 (2004) 6225-6232
9. El-Sherbiny D.A., Khalifa A.E., Attia A.S., and Eldenshary E.E. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacology Biochemistry and Behavior 76 (2003) 525-533
10. Friedman J.I. Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists. Psychopharmacology (Berlin) 174 (2004) 45-53
11. Hostanska K., Reichling J., Bommer S., Weber M., and Saller R. Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. European Journal of Pharmaceutics and Biopharmaceutics 56 (2003) 121-132
12. Jones C.K., and Shannon H.E. Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats. European Journal of Pharmacology 391 (2000) 105-112
13. Khalifa A.E. Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice. Journal of Ethnopharmacology 76 (2001) 49-57
14. Khalifa A.E. Neural monoaminergic mediation of the effect of St. John's wort extract on prepulse inhibition of the acoustic startle response in rats. Journal of Psychopharmacology 19 (2005) 467-472
15. Klusa V., Germane S., Noldner M., and Chatterjee S.S. Hypericum extract and hyperforin: memory-enhancing properties in rodents. Pharmacopsychiatry 34 (2001) S61-S69
16. Kodsi M.H., and Swerdlow N.R. Prepulse inhibition in the rat is regulated by ventral and caudodorsal striato-pallidal circuitry. Behavioral Neuroscience 109 (1995) 912-928
17. Kozlovskaya M.M., Seredenin S.B., Kozlovskii I.I., Val'dman E.A., Andreeva L.A., and Myasoedov N.F. A comparative study of the effect of tuftsin fragments on passive avoidance learning characteristics. Pharmaceutical Chemistry Journal 35 (2001) 121-123
18. Kumar V., Singh P.N., Muruganandam A.V., and Bhattacharya S.K. Effect of Indian Hypericum perforatum Linn on animal models of cognitive dysfunction. Journal of Ethnopharmacology 72 (2000) 119-128
19. Leuner K., Kazanski V., Müller M., Essin K., Henke B., Gollasch M., Harteneck C., and Müller W.E. Hyperforin a key constituent of St. John's wort specifically activates TRPC6 channels. The FASEB Journal 21 (2007) 4101-4111
20. Medina M.A., Martínez-Poveda B., Amores-Sánchez M.I., and Quesada A.R. Hyperforin: more than an antidepressant bioactive compound?. Life Sciences 79 (2006) 105-111
21. Meruelo D., Lavie G., and Lavie D. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proceedings of the National Academic Sciences of United States of America 85 (1988) 5230-5234
22. Miller A.L. St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions. Alternative Medical Reviews 3 (1998) 18-26
23. Norenberg M.D., and Rao K.V. The mitochondrial permeability transition in neurologic disease. Neurochemistry International 50 (2007) 983-997
24. Raedler T.J., Knable M.B., Jones D.W., Urbina R.A., Egan M.F., and Weinberger D.R. Central muscarinic acetylcholine receptor availability in patients treated with clozapine. Neuropsychopharmacology 28 (2003) 1531-1537
25. Roz N., and Rehavi M. Hyperforin depletes synaptic vesicles content and induces compartmental redistribution of nerve ending monoamines. Life Sciences 75 (2004) 2841-2850
26. Sato S., Gobbel G.T., Honkaniemi J., Li Y., Kondo T., Murakami K., Sato M., Copin J., and Chan P.H. Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic. Brain Research 745 (1997) 343-347
27. Schempp C.M., Kirkin V., Simon-Haarhaus B., Kersten A., Kiss J., Termeer C.C., Gilb B., Kaufmann T., Borner C., Sleeman J.P., and Simon J.C. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene 21 (2002) 1242-1250
28. Schwarz D., Kisselev P., and Roots I. St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. Cancer Research 63 (2003) 8062-8068
29. +1. Journal of Pharmacology and Experimental Therapeutics 290 (1999) 1363-1368
30. Trofimiuk E., Walesiuk A., and Braszko J.J. St John's wort (Hypericum perforatum) diminishes cognitive impairment caused by the chronic restraint stress in rats. Pharmacological Research 51 (2005) 239-246
31. Uzbay T.I. Hypericum perforatum and substance dependence: a review. Phytotherapy Research 22 (2008) 578-582
32. Uzbay I.T., Coskun I., Kayir H., Ozturk N., and Ozturk Y. Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: a possible role of nitric oxide. Phytotherapy Research 21 (2007) 415-419
33. Whiskey E., Werneke U., and Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. International Clinical Psychopharmacology 16 (2001) 239-252
34. Wu M., Jenden D.J., Fairchild M.D., and Siegel J.M. Cholinergic mechanisms in startle and prepulse inhibition: effects of the false cholinergic precursor N-aminodeanol. Behavioral Neuroscience 107 (1993) 306-316