Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats

European Journal of Pharmacology

Volumn 391, Issue 1-2, 2000, Pages 105-112

  Jones, Carrie K ^a,b   Shannon, Harlan E ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Apomorphine; Dopamine receptor; Glutamate receptor; Muscarinic acetylcholine receptor; Phencyclidine; Prepulse inhibition; Rat; Scopolamine; Startle

Indexed keywords

APOMORPHINE; DOPAMINE RECEPTOR; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE; SCOPOLAMINE;

ACOUSTIC REFLEX; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; STARTLE REFLEX;

ACOUSTIC STIMULATION; ANIMALS; APOMORPHINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MUSCARINIC ANTAGONISTS; PHENCYCLIDINE; RATS; RATS, SPRAGUE-DAWLEY; SCOPOLAMINE; STARTLE REACTION;

EID: 0034629025     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00055-8     Document Type: Article

References (23)

1. Braff D.L., Grillion C., Geyer M.A. Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry. 49:1992;206-215.
2. Braff D., Stone C., Callaway E., Geyer M., Glick I., Bali L. Prestimulus effects of human startle reflex in normals and schizophrenics. Psychophysiology. 15:1978;339-343.
3. Cadenhead K.S., Geyer M.A., Braff D.L. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am. J. Psychiatry. 150:1993;1862-1867.
4. Davis M. Neurochemical modulation of sensory-motor reactivity: acoustic and tactile startle reflexes. Neurosci. Biobehav. Rev. 4:1980;241-263.
5. Davis M., Mansbach R.S., Swerdlow N.R., Campeau S., Braff D.L. Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats. Psychopharmacology. 102:1990;1-4.
6. Drachman D.R., Sahakian B.J. The effects of cholinergic agents on human learning and memory. Growdon T.H., Wurtman R.J. Nutrition in the Brain. 1979;351 Raven Press, New York.
7. Graham F.K. The more or less startling effects of weak prestimulation. Psychophysiology. 12:1975;238-248.
8. Grillon C., Morgan C.A., Southwick S.M., Davis M., Charney D.S. Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res. 64:1996;169-178.
9. Hoffman H.S., Ison J.R. Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system process sensory input. Psychol. Rev. 87:1980;175-189.
10. Ison J.R., Hammond G.R. Modification of the startle reflex in the rat by changes in the auditory and visual environments. J. Comp. Physiol. Psychol. 75:1971;435-452.
11. Kaltwasser M.T. Startle-inducing acoustic stimuli evoke ultrasonic vocalization in the rat. Physiol. Behav. 48:1990;13-17.
12. Koch M., Kungel M., Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp. Brain Res. 97:1993;71-82.
13. Mansbach R.S., Geyer M.A. Effect of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology. 2:1989;299-308.
14. Mansbach R.S., Geyer M.A., Braff D.L. Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology. 94:1988;507-514.
15. Peng P.Y., Mansbach R.S., Braff D.L., Geyer M.A. A D2 Dopamine receptor agonist disrupts sensorimotor gating in rats: implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology. 3:1990;211-218.
16. Pouretemad H.R., Thompson P.J., Fenwick P.B. Impaired sensorimotor gating in patients with non-epileptic seizures. Epilepsy Res. 31:1998;1-12.
17. Robbins T.W. Arousal systems and attentional processes. Biol. Psychol. 45:1997;57-71.
18. Swerdlow N., Geyer M.A. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol. Biochem. Behav. 44:1993;741-744.
19. Swerdlow N., Geyer M.A. Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus. Behav. Neurosci. 107:1993;104-117.
20. Swerdlow N., Keith V.A., Braff D.L., Geyer M.A. Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J. Pharmacol. Exp. Ther. 256:1991;530-536.
21. Williams J.M., Hamilton L.W., Carlton P.L. Pharmacological and anatomical dissociation of two types of habituation. J. Comp. Physiol. Psychol. 87:1974;724-732.
22. Wu M., Jenden D.J., Fairchild M.D., Siegel J.M. Cholinergic mechanisms in startle and prepulse inhibition: effects of the false cholinergic precursor N-aminodeanol. Behav. Neurosci. 107:1993;306-316.
23. Young K.A., Randall P.K., Wilcox R.E. Dose and time response analysis of apomorphine's effect on prepulse inhibition of acoustic startle. Behav. Brain Res. 42:1991;43-48.