Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI

Peptides

Volumn 29, Issue 6, 2008, Pages 963-968

  Wang, Kai rong ^a   Zhang, Bang zhi ^a,b   Zhang, Wei ^a   Yan, Jie xi ^a   Li, Jia ^a   Wang, Rui ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Analog; Antimicrobial peptide; Antitumor; Cell selectivity; Polybia MPI

Indexed keywords

ANTINEOPLASTIC AGENT; ISOLEUCYLASPARTYLTRYPTOPHYLLYSYLLYSYLLEUCYLLEUCYLASPARTYLALANYLALANYL LYSYLGLUTAMINYLISOLEUCYLLEUCINAMIDE; ISOLEUCYLASPARTYLTRYPTOPHYLLYSYLLYSYLLEUCYLLEUCYLASPARTYLPROLYLALANYL LYSYLGLUTAMINYLISOLEUCYLLEUCINAMIDE; ISOLEUCYLASPARTYLTRYPTOPHYLLYSYLLYSYLLEUCYLLEUCYLPROLYLALANYLALANYL LYSYLGLUTAMINYLISOLEUCYLLEUCINAMIDE; ISOLEUCYLASPARTYLTRYPTOPHYLLYSYLLYSYLLEUCYLPROLYLASPARTYLALANYLALANYL LYSYLGLUTAMINYLISOLEUCYLLEUCINAMIDE; POLYBIA MPI; POLYPEPTIDE ANTIBIOTIC AGENT;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FIBROBLASTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MICE; NIH 3T3 CELLS; PROLINE; PROSTATIC NEOPLASMS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY BLADDER NEOPLASMS; WASP VENOMS; WASPS;

MURINAE; NEGIBACTERIA; POLYBIA; POLYBIA PAULISTA; POSIBACTERIA; RATTUS;

EID: 43049145799     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.01.015     Document Type: Article

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