Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

Frontiers of Medicine in China

Volumn 1, Issue 4, 2007, Pages 373-376

  Lu, Ling ^a   Zhang, Feng ^a   Pu, Liyong ^a   Yao, Aihua ^a   Yu, Yue ^a   Sun, Beicheng ^a   Li, Guoqiang ^a   Wang, Xuehao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CD4+CD25+ T regulatory cells; Immune tolerance; Liver transplantation; Regulatory; T lymphocytes

Indexed keywords

EID: 36448991217     PISSN: 16737342     EISSN: 16737458     Source Type: Journal    
DOI: 10.1007/s11684-007-0072-9     Document Type: Article

References (18)

1. Kamada N. The immunology of experimental liver transplantation in the rat. Immunology, 1985, 55(3): 369-389
2. Sakaguchi S. Regulatory T cells: Key controllers of immunologic self-tolerance. Cell, 2000, 101(5): 455-458
3. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Ann Rev Immunol, 2004, 22: 531-562
4. + T cells promote engraftment and tolerance following MHC mismatched hematopoietic cell transplantation. Blood, 2005, 105(4): 1,828-1,836
5. Asakura H, Ku G, Kataoka M, Flye M W. Regulatory cells develop after the spontaneous acceptance of rat liver allograts. Surgery, 2004, 136(3): 532-536
6. Kamada N, Calne R Y. Orthotopic liver transplantation in the rat: Techniques using cuff for portal vein anastomosis and biliary drainage. Transplantation, 1979, 28(1): 47-50
7. + T cells in rats. Int Immunol, 2004, 16(2): 365-375
8. Meyer D, Thorwarth W, Otto C, Gasser M, Gassel H, Timmermann W, Ulrichs K, Thiede A. Early T-cell inactivation and apoptosis-critical events for tolerance induction after allogeneic liver transplantation. Transplant Pro, 2001, 33(1-2): 256-258
9. Walsh P T, Taylor D K, Turka L A. Tregs and transplantation tolerance. J Clin Invest, 2004, 114(10): 1,398-1,403
10. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science, 2003, 299(5609): 1,057-1,061
11. Albert M H, Liu Y, Anasetti C, Yu X Z. Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur J Immunol, 2005, 35(9): 2,598-2,607
12. Waldmann H, Cobbold S. Exploiting tolerance processes in transplantation. Science, 2004, 305(5681): 209-212
13. + regulatory T cells in rat. Journal of Nanjing Medical University, 2006, 20(4): 238-241
14. Otto C, Kauczok J, Martens N, Steger U, Müller I, Meyer D, Timmermann W, Ulrichs K, Gassel H J. Mechanisms of tolerance induction after rat liver transplantation: Intrahepatic CD4 + T cells produce different cytokines during rejection and tolerance in response to stimulation. J Gastrointest Surg, 2002, 6(3): 455-463
15. + T regulatory cells. Eur J Immunol, 2002, 32(6): 1,621-1,630
16. Pu L Y, Wang X H, Zhang F, Li X C, Yao A H, Yu Y, Lv L, Li G Q. Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation. Surgery, 2007, 142(1): 67-73
17. + cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J Immunol, 2004, 172(9): 5,213-5,221
18. + regulatory T cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2006, 22(4): 417-419 (in Chinese)