Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure

Psychopharmacology

Volumn 203, Issue 4, 2009, Pages 805-818

  Firk, Christine ^a   Markus, C Rob ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

5 HTTLPR; Major depression; Serotonin transporter gene polymorphism; Stress; Tryptophan depletion

Indexed keywords

HYDROCORTISONE; SEROTONIN TRANSPORTER; TRYPTOPHAN;

ACUTE STRESS; ADULT; ALLELE; AMINO ACID BLOOD LEVEL; ARTICLE; ATTENTION; COGNITION; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; MALE; MEMORY; MOOD; PRIORITY JOURNAL; PROTEIN DEPLETION; REACTION TIME; RECALL;

AFFECT; ATTENTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GENOTYPE; HUMANS; MALE; MEMORY; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; TRYPTOPHAN; YOUNG ADULT;

EID: 63449141881     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1428-9     Document Type: Article

References (86)

1. AT Beck CH Ward M Mendelson J Mock J Erbaugh 1961 An inventory for measuring depression Arch Gen Psychiatry 4 561 571
2. C Benkelfat MA Ellenbogen P Dean RM Palmour SN Young 1994 Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders Arch Gen Psychiatry 51 687 697
3. A Blokland C Lieben NEP Deutz J Schmitt 2004 Acute tryptophan depletion: comparing the effects of an amino acid mixture with a gelatin-based protein in man and rats Curr Top Nutraceutical Res 2 161 169
4. BP Bradley K Mogg R Williams 1995 Implicit and explicit memory for emotion-congruent information in clinical depression and anxiety Behav Res Ther 33 755 770
5. LL Carpenter GM Anderson GH Pelton JA Gudin PD Kirwin LH Price GR Heninger CJ McDougle 1998 Tryptophan depletion during continuous CSF sampling in healthy human subjects Neuropsychopharmacology 19 26 35
6. A Caspi K Sugden TE Moffitt A Taylor IW Craig H Harrington J McClay J Mill J Martin A Braithwaite R Poulton 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 386 389
7. DA Collier G Stober T Li A Heils M Catalano D Di Bella MJ Arranz RM Murray HP Vallada D Bengel CR Muller GW Roberts E Smeraldi G Kirov P Sham KP Lesch 1996 A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders Mol Psychiatry 1 453 460
8. S Davis DJ Heal SC Stanford 1995 Long-lasting effects of an acute stress on the neurochemistry and function of 5-hydroxytryptaminergic neurones in the mouse brain Psychopharmacology (Berl) 118 267 272
9. P Dayan QJ Huys 2008 Serotonin, inhibition, and negative mood PLoS Comput Biol 4 e4
10. ER De Kloet GL Kovacs G Szabo G Telegdy B Bohus DH Versteeg 1982 Decreased serotonin turnover in the dorsal hippocampus of rat brain shortly after adrenalectomy: selective normalization after corticosterone substitution Brain Res 239 659 663
11. ER De Kloet DH Versteeg GL Kovacs 1983 Aldosterone blocks the response to corticosterone in the raphe-hippocampal serotonin system Brain Res 264 323 327
12. PL Delgado DS Charney LH Price GK Aghajanian H Landis GR Heninger 1990 Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan Arch Gen Psychiatry 47 411 418
13. PL Delgado HL Miller RM Salomon J Licinio JH Krystal FA Moreno GR Heninger DS Charney 1999 Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action Biol Psychiatry 46 212 220
14. CM Deveney PJ Deldin 2004 Memory of faces: a slow wave ERP study of major depression Emotion 4 295 304
15. K Erickson WC Drevets L Clark DM Cannon EE Bain CA Jr Zarate DS Charney BJ Sahakian 2005 Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder Am J Psychiatry 162 2171 2173
16. EA Evers DE Tillie FM van der Veen CK Lieben J Jolles NE Deutz JA Schmitt 2005 Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers Psychopharmacology (Berl) 178 92 99
17. JD Fernstrom RJ Wurtman 1971 Brain serotonin content: physiological dependence on plasma tryptophan levels Science 173 149 152
18. C Firk CR Markus 2007 Review: Serotonin by stress interaction: a susceptibility factor for the development of depression? J Psychopharmacol 21 538 544
19. C Firk CR Markus 2008 Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stress Psychopharmacology (Berl) 199 151 160
20. P Fusar-Poli P Allen P McGuire A Placentino M Cortesi J Perez 2006 Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature Psychopharmacology (Berl) 188 131 143
21. GL Gessa G Biggio F Fadda GU Corsini A Tagliamonte 1974 Effect of the oral administration of tryptophan-free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism J Neurochem 22 869 870
22. X Gonda G Juhasz A Laszik Z Rihmer G Bagdy 2005 Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene J Affect Disord 87 291 297
23. X Gonda Z Rihmer T Zsombok G Bagdy KK Akiskal HS Akiskal 2006 The 5HTTLPR polymorphism of the serotonin transporter gene is associated with affective temperaments as measured by TEMPS-A J Affect Disord 91 125 131
24. IH Gotlib J Joormann KL Minor J Hallmayer 2008 HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression Biol Psychiatry 63 847 51
25. BD Greenberg TJ Tolliver SJ Huang Q Li D Bengel DL Murphy 1999 Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets Am J Med Genet 88 83 87
26. AR Hariri VS Mattay A Tessitore B Kolachana F Fera D Goldman MF Egan DR Weinberger 2002 Serotonin transporter genetic variation and the response of the human amygdala Science 297 400 403
27. AR Hariri EM Drabant KE Munoz BS Kolachana VS Mattay MF Egan DR Weinberger 2005 A susceptibility gene for affective disorders and the response of the human amygdala Arch Gen Psychiatry 62 146 152
28. G Hayward GM Goodwin PJ Cowen CJ Harmer 2005 Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms Biol Psychiatry 57 517 524
29. A Heils A Teufel S Petri G Stober P Riederer D Bengel KP Lesch 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 2621 2624
30. A Heinz DF Braus MN Smolka J Wrase I Puls D Hermann S Klein SM Grusser H Flor G Schumann K Mann C Buchel 2005 Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter Nat Neurosci 8 20 21
31. D Hermans J De Houwer 1994 Affective and subjective familiarity ratings of 740 Dutch words Psychologica Belgica 34 115 139
32. XZ Hu RH Lipsky G Zhu LA Akhtar J Taubman BD Greenberg K Xu PD Arnold MA Richter JL Kennedy DL Murphy D Goldman 2006 Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder Am J Hum Genet 78 815 826
33. TE Joiner Jr F Johnson K Soderstrom JS Brown 2003 Is there an association between serotonin transporter gene polymorphism and family history of depression? J Affect Disord 77 273 275
34. T Klaassen WJ Riedel A van Someren NE Deutz A Honig HM van Praag 1999 Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders Biol Psychiatry 46 489 497
35. T Klaassen WJ Riedel NE Deutz HM Van Praag 2002 Mood congruent memory bias induced by tryptophan depletion Psychol Med 32 167 172
36. KP Lesch U Balling J Gross K Strauss BL Wolozin DL Murphy P Riederer 1994 Organization of the human serotonin transporter gene J Neural Transm Gen Sect 95 157 162
37. Lezak MD (2004) Auditory-verbal learning test (AVLT). In: Lezak MD, Howieson DB, Loring DW (eds) Neuropsychological assessment, 4th edn. Oxford University Press, London, pp 422-429
38. SL Lim JH Kim 2005 Cognitive processing of emotional information in depression, panic, and somatoform disorder J Abnorm Psychol 114 50 61
39. FE Lotrich BG Pollock 2004 Meta-analysis of serotonin transporter polymorphisms and affective disorders Psychiatr Genet 14 121 129
40. Maes M, Meltzer HY (1995) The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 933-944
41. Markus CR (2008) Dietary amino acids and brain serotonin function; implications for stress-related affective changes. Neuromolecular Med (in press). doi: 10.1007/s12017-008-8039-9
42. CR Markus G Panhuysen A Tuiten H Koppeschaar D Fekkes ML Peters 1998 Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task? Appetite 31 49 65
43. CR Markus B Olivier GE Panhuysen J Van Der Gugten MS Alles A Tuiten HG Westenberg D Fekkes HF Koppeschaar EE de Haan 2000 The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress Am J Clin Nutr 71 1536 1544
44. CR Markus G Panhuysen A Tuiten H Koppeschaar 2000 Effects of food on cortisol and mood in vulnerable subjects under controllable and uncontrollable stress Physiol Behav 70 333 342
45. CR Markus B Olivier EH de Haan 2002 Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects Am J Clin Nutr 75 1051 1056
46. AA Marsh EC Finger B Buzas N Soliman RA Richell M Vythilingham DS Pine D Goldman RJ Blair 2006 Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion Psychopharmacology (Berl) 189 387 394
47. GE Matt C Vazquez WK Campbell 1992 Mood-congruent recall of affectively toned stimuli: a meta-analytic review Clin Psychol Rev 12 227 255
48. JH Meyer AA Wilson S Sagrati D Hussey A Carella WZ Potter N Ginovart EP Spencer A Cheok S Houle 2004 Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study Am J Psychiatry 161 826 835
49. K Mogg BP Bradley 2005 Attentional bias in generalized anxiety disorder versus depressive disorder Cogn Ther Res 29 29 45
50. EA Moja E Rocchi F Benedetti F Paolillo G Casalgrandi M Ponz de Leon 1991 Decrease in plasma tryptophan after a tryptophan-free amino acid solution. A comparison between cirrhotic and control subjects Life Sci 48 409 418
51. FA Moreno GR Heninger CA McGahuey PL Delgado 2000 Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes Biol Psychiatry 48 327 329
52. FC Murphy BJ Sahakian JS Rubinsztein A Michael RD Rogers TW Robbins ES Paykel 1999 Emotional bias and inhibitory control processes in mania and depression Psychol Med 29 1307 1321
53. FC Murphy KA Smith PJ Cowen TW Robbins BJ Sahakian 2002 The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers Psychopharmacology (Berl) 163 42 53
54. A Neumeister A Konstantinidis J Stastny MJ Schwarz O Vitouch M Willeit N Praschak-Rieder J Zach M de Zwaan B Bondy M Ackenheil S Kasper 2002 Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression Arch Gen Psychiatry 59 613 620
55. A Neumeister T Young J Stastny 2004 Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter Psychopharmacology (Berl) 174 512 524
56. A Neumeister XZ Hu DA Luckenbaugh M Schwarz AC Nugent O Bonne P Herscovitch D Goldman WC Drevets DS Charney 2006 Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls Arch Gen Psychiatry 63 978 986
57. JL Nuller MN Ostroumova 1980 Resistance to inhibiting effect of dexamethasone in patients with endogenous depression Acta Psychiatr Scand 61 169 177
58. ML Peters GL Godaert RE Ballieux M van Vliet JJ Willemsen FC Sweep CJ Heijnen 1998 Cardiovascular and endocrine responses to experimental stress: effects of mental effort and controllability Psychoneuroendocrinology 23 1 17
59. L Pezawas A Meyer-Lindenberg EM Drabant BA Verchinski KE Munoz BS Kolachana MF Egan VS Mattay AR Hariri DR Weinberger 2005 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression Nat Neurosci 8 828 834
60. RJ Porter P Gallagher S Watson AH Young 2004 Corticosteroid-serotonin interactions in depression: a review of the human evidence Psychopharmacology (Berl) 173 1 17
61. WJ Riedel T Klaassen NE Deutz A van Someren HM van Praag 1999 Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation Psychopharmacology (Berl) 141 362 369
62. M Rinck ES Becker 2005 A comparison of attentional biases and memory biases in women with social phobia and major depression J Abnorm Psychol 114 62 74
63. JP Roiser LJ Cook JD Cooper DC Rubinsztein BJ Sahakian 2005 Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users Am J Psychiatry 162 609 612
64. JP Roiser AD Blackwell R Cools L Clark DC Rubinsztein TW Robbins BJ Sahakian 2006 Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion Neuropsychopharmacology 31 10 2264 2272
65. JP Roiser U Muller L Clark BJ Sahakian 2007 The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention Int J Neuropsychopharmacol 10 449 461
66. JS Rubinsztein RD Rogers WJ Riedel MA Mehta TW Robbins BJ Sahakian 2001 Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers Psychopharmacology (Berl) 154 319 326
67. HG Ruhe NS Mason AH Schene 2007 Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies Mol Psychiatry 12 331 359
68. Sambeth A, Riedel WJ, Tillie DE, Blokland A, Postma A, Schmitt JA (2008) Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drink. J Psychopharmacol (in press). doi: 10.1177/0269881108089577
69. A Serretti L Mandelli C Lorenzi A Pirovano P Olgiati C Colombo E Smeraldi 2007 Serotonin transporter gene influences the time course of improvement of "core" depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders Psychiatry Res 149 185 193
70. T Smeets M Jelicic H Merckelbach 2006 The effect of acute stress on memory depends on word valence Int J Psychophysiol 62 30 37
71. E Smeraldi R Zanardi F Benedetti D Di Bella J Perez M Catalano 1998 Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine Mol Psychiatry 3 508 511
72. S Sobczak A Honig NA Nicolson WJ Riedel 2002 Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controls Neuropsychopharmacology 27 834 842
73. S Sobczak WJ Riedel I Booij M Aan Het Rot NE Deutz A Honig 2002 Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteers Psychol Med 32 503 515
74. T Suhara A Takano Y Sudo T Ichimiya M Inoue F Yasuno Y Ikoma Y Okubo 2003 High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography Arch Gen Psychiatry 60 386 391
75. MT Tull KL Gratz 2008 Further examination of the relationship between anxiety sensitivity and depression: the mediating role of experiential avoidance and difficulties engaging in goal-directed behavior when distressed J Anxiety Disord 22 199 210
76. R Uher P McGuffin 2008 The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis Mol Psychiatry 13 131 146
77. AJ Van der Does 2001 The effects of tryptophan depletion on mood and psychiatric symptoms J Affect Disord 64 107 119
78. HM Van Praag 2004 Can stress cause depression? Prog Neuropsychopharmacol Biol Psychiatry 28 891 907
79. AN Voineskos AA Wilson A Boovariwala S Sagrati S Houle P Rusjan S Sokolov EP Spencer N Ginovart JH Meyer 2007 Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [(11)C]DASB positron emission tomography Psychopharmacology (Berl) 193 539 545
80. FDM Wald GJ Mellenbergh 1990 De verkorte versie van de Nederlandse vertaling van de Profile of Mood States (POMS) Ned Tijdschr Psychol 45 86 90
81. E Walderhaug A Magnusson A Neumeister J Lappalainen H Lunde H Refsum NI Landro 2007 Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people Biol Psychiatry 62 593 599
82. D Watson LA Clark A Tellegen 1988 Development and validation of brief measures of positive and negative affect: the PANAS scales J Pers Soc Psychol 54 1063 1070
83. JR Wendland BJ Martin MR Kruse KP Lesch DL Murphy 2006 Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 Mol Psychiatry 11 224 226
84. WA Williams SE Shoaf D Hommer R Rawlings M Linnoila 1999 Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers J Neurochem 72 1641 1647
85. SN Young SE Smith RO Pihl FR Ervin 1985 Tryptophan depletion causes a rapid lowering of mood in normal males Psychopharmacology (Berl) 87 173 177
86. G Zalsman YY Huang MA Oquendo AK Burke XZ Hu DA Brent SP Ellis D Goldman JJ Mann 2006 Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression Am J Psychiatry 163 1588 1593