Tryptophan depletion and risk of depression relapse: A prospective study of tryptophan depletion as a potential predictor of depressive episodes

Biological Psychiatry

Volumn 48, Issue 4, 2000, Pages 327-329

  Moreno, Francisco A ^a   Heninger, George R ^b   McGahuey, Cynthia A ^a   Delgado, Pedro L ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Depletion paradigm; Major depression; Serotonin; Vulnerability

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; MALE; MOOD; PRIORITY JOURNAL; REMISSION; RISK FACTOR; SEROTONIN BRAIN LEVEL; SURVIVAL;

ADULT; CROSS-OVER STUDIES; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RECURRENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN;

EID: 0034663368     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00893-3     Document Type: Article

References (10)

1. Benkelfat C., Seletti E., Mark A., Dean P., Palmour R.M., Young S.N. Mood-lowering effects of tryptophan depletion Enhanced susceptibility in young man at genetic risk for major affective disorders . Arch Gen Psychiatry. 51:1994;687-697.
2. Curzon G. Influence of plasma tryptophan on brain 5-HT synthesis and serotonergic activity. Haber B., Gabay S. Serotonin Current Aspects of Neurochemistry and Function . 1981;207-219 Plenum Press, New York.
3. Horwath E., Johnson J., Klerman G.L., Weissman M.M. Depressive symptoms as relative and attributable risk factors for first-onset major depression. Arch Gen Psychiatry. 49:1992;817-823.
4. Keller M.B., Lavori P.W., Lewis C.E., Klerman G.L. Predictors of relapse in major depressive disorder. JAMA. 250:1983;3299-3304.
5. Mazure C.M., Nelson J.C., Price L.H. Reliability and validity of the symptoms of major depressive illness. Arch Gen Psychiatry. 43:1986;451-456.
6. Metz C.E. ROC methodology in radiologic imaging. Invest Radiol. 21:1986;720-733.
7. Moreno F.A., Gelenberg A.J., Heninger G.R., Potter R.L., McKnight K., Allen J., et al. Tryptophan depletion and depressive vulnerability. Biol Psychiatry. 46:1999;498-505.
8. Rush A.J., Giles D.E., Schlesser M.A., Orsulak P.J., Weissenburger J.E., Fulton C.L., et al. Dexamethasone response, thyrotropin-releasing hormone stimulation, rapid eye movement latency, and subtypes of depression. Biol Psychiatry. 41:1997;915-928.
9. Smith K.A., Fairburn C.G., Cowen P.J. Relapse of depression after rapid tryptophan depletion. Lancet. 349:1997;915-919.
10. Spitzer R.L. Structured Clinical Interview for DSM III-R. 1987;New York State Psychiatric Institute, Biometrics Research Department, New York.