A nonintrusive method of measuring the local mechanical properties of soft hydrogels using magnetic microneedles

Journal of Biomechanical Engineering

Volumn 131, Issue 2, 2009, Pages

  Chippada, Uday ^a   Yurke, Bernard ^b   Georges, Penelope C ^c   Langrana, Noshir A ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Boise State University   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Hydrogels; LABVIEW; Magnet manipulator; Microneedles; Stiffness

Indexed keywords

APPLIED MAGNETIC FIELDS; CELL ATTACHMENTS; CELL MORPHOLOGY; CROSS-LINKED HYDROGELS; CROSSLINKER; FEEDBACK CIRCUITS; FIELD GRADIENT; FIELD VALUES; FUNCTION OF TIME; HALL PROBE; LABVIEW; LOCAL PROPERTY; MAGNETIC NEEDLES; MECHANICAL DISTURBANCE; MECHANICAL STIFFNESS; MICRONEEDLES; MODULUS OF ELASTICITY; NON-INTRUSIVE METHOD; ON-DEMAND; POLYACRYLAMIDE HYDROGELS; TYPE-I COLLAGEN; ZERO MAGNETIC FIELDS;

BIOMECHANICS; CELL CULTURE; ELASTIC MODULI; ELASTICITY; GELS; GROWTH KINETICS; HYDROGELS; MAGNETIC FIELDS; MAGNETIC MATERIALS; MAGNETS; MANIPULATORS; NEEDLES; POLES; STIFFNESS; SUBSTRATES;

MECHANICAL PROPERTIES;

POLYACRYLAMIDE;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRUCTURE; ELASTICITY; FORCE; HYDROGEL; IMAGING SYSTEM; MAGNET; MAGNETIC FIELD; NEEDLE; ANIMAL; ASTROCYTE; CHEMISTRY; MAGNETISM; MECHANICAL STRESS; NERVE CELL; PHYSIOLOGY; RAT; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT; TORQUE; ULTRASTRUCTURE; YOUNG MODULUS;

ANIMALS; ASTROCYTES; CELLS, CULTURED; ELASTIC MODULUS; ELASTICITY; HYDROGELS; MAGNETICS; MICROSCOPY, ELECTRON, SCANNING; NEEDLES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TORQUE;

EID: 63449141757     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.3005166     Document Type: Article

References (33)

1. Lo, C. M., Wang, H. B., Dembo, M., and Wang, Y., 2000, "Cell Movement is Guided by the Rigidity of the Substrate," Biophys. J., 79(1), pp. 144-152. (Pubitemid 30436733)
2. Wang, H. B., Dembo, M., and Wang, Y. L., 2000, "Substrate Flexibility Regulates Growth and Apoptosis of Normal but not Transformed Cells," Am. J. Physiol.: Cell Physiol., 279(5), pp. 1345-1350.
3. Beningo, K. A., and Wang, Y., 2002, "Fc-Receptor-Mediated Phagocytosis is Regulated by Mechanical Properties of the Target," J. Cell. Sci., 115(4), pp. 849-856. (Pubitemid 34196344)
4. Pelham, R. J., Jr., and Wang, Y., 1997, "Cell Locomotion and Focal Adhesions are Regulated by Substrate Flexibility," Proc. Natl. Acad. Sci. U.S.A., 94(25), pp. 13661-13665. (Pubitemid 28009639)
5. Flanagan, L. A., Marg, B., Osterfield, M., and Janmey, P. A., 2002, "Neurite Branching on Deformable Substrates," NeuroReport, 13(18), pp. 2411-2415.
6. Lauffenburger, D. A., and Horwitz, A. F., 1996, "Cell Migration: A Physically Integrated Molecular Process," Cell, 84(3), pp. 359-369.
7. Horkay, F., and Zrinyi, M., 1982, "Studies on the Mechanical and Swelling Behavior of Polymer Networks Based on the Scaling Concept. 4. Extension of the Scaling Approach to Gels Swollen to Equilibrium in a Diluent of Arbitrary Activity," Macromolecules, 15(5), pp. 1306-1310.
8. Zhang, X., Hu, Z., and Li, Y., 1998, "Rubber Elasticity of Polyacrylamide Gels in High Network Concentration," Polymer, 39(13), pp. 2783-2788. (Pubitemid 128396446)
9. Wong, J. Y., Velasco, A., Rajagopalan, P., and Pham, Q., 1999, "Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogels," J. Cell. Sci., 112, pp. 1908-1913.
10. Lee, J., 1994, "Traction Forces Generated by Locomoting Keratocytes," J. Cell Biol., 127(6), pp. 1957-1964.
11. Radmacher, M., Tillamnn, R. W., Fritz, M., and Gaub, H. E., 1992, "From Molecules to Cells: Imaging Soft Samples With the Atomic Force Microscope," Science, 257(5078), pp. 1900-1905. (Pubitemid 23604211)
12. Radmacher, M., Fritz, M., and Hansma, P. K., 1995, "Imaging Soft Samples With the Atomic Force Microscope: Gelatin in Water and Propanol," Biophys. J., 69(1), p. 264.
13. Yanai, M., Butler, J. P., Suzuki, T., Kanda, A., Kurachi, M., Tashiro, H., and Sasaki, H., 1999, "Intracellular Elasticity and Viscosity in the Body, Leading, and Trailing Regions of Locomoting Neutrophils," Am. J. Physiol.: Cell Physiol., 277(3), pp. 432-440.
14. Yamada, S., Wirtz, D., and Kuo, S. C., 2000, "Mechanics of Living Cells Measured by Laser Tracking Microrheology," Biophys. J., 78(4), pp. 1736-1747.
15. Bausch, A. R., Ziemann, F., Boulbitch, A. A., Jacobson, K., and Sackmann, E., 1998, "Local Measurements of Viscoelastic Parameters of Adherent Cell Surfaces by Magnetic Bead Microrheometry," Biophys. J., 75(4), pp. 2038-2049.
16. Wang, N., Butler, J. P., and Ingber, D. E., 1993, " Mechanotransduction Across the Cell Surface and Through the Cytoskeleton," Science, 260(5111), pp. 1124-1127.
17. Yurke, B., Lin, D. C., and Langrana, N. A., 2006, "Use of DNA Nanodevices in Modulating the Mechanical Properties of Polyacrylamide Gels," DNA Computing: 11th International Workshop on DNA Computing, DNA11, London, ON, Canada, Jun. 6-9, 2005, Revised Selected Papers.
18. Lin, D. C., Yurke, B., and Langrana, N. A., 2004, "Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel," ASME J. Biomech. Eng., 126, pp. 104-110.
19. Lin, D. C., Yurke, B., and Langrana, N., 2005, "Inducing Reversible Stiffness Changes in DNA-Crosslinked Gels," J. Mater. Res., 20(6), pp. 1456-1464.
20. Lin, D. C., Yurke, B., and Langrana, N. A., 2005, "Use of Rigid Spherical Inclusions in Young's Moduli Determination: Application to DNA-Crosslinked Gels," ASME J. Biomech. Eng., 127, pp. 571-579.
21. Gosse, C., and Croquette, V., 2002, "Magnetic Tweezers: Micromanipulation and Force Measurement at the Molecular Level," Biophys. J., 82(6), pp. 3314-3329. (Pubitemid 34547674)
22. Amblard, F., Yurke, B., Pargellis, A., and Leibler, S., 1996, "A Magnetic Manipulator for Studying Local Rheology and Micromechanical Properties of Biological Systems," Rev. Sci. Instrum., 67, pp. 818-827. (Pubitemid 126579792)
23. Skomski, R., and Coey, J. M. D., 1999, Permanent Magnetism, Institute of Physics, Philadelphia, PA.
24. de Vries, A. H. B., Krenn, B. E., van Driel, R., and Kanger, J. S., 2005, "Micro Magnetic Tweezers for Nanomanipulation Inside Live Cells," Biophys. J., 88(30), pp. 2137-2144.
25. Knapp, D. M., Barocas, V. H., Moon, A. G., Yoo, K., Petzold, L. R., and Tranquillo, R. T., 1997, "Rheology of Reconstituted Type I Collagen Gel in Confined Compression," J. Rheol., 41, pp. 971-993. (Pubitemid 127609537)
26. Baumberger, T., Caroli, C., and Martina, D., 2006, "Solvent Control of Crack Dynamics in a Reversible Hydrogel," Nature Mater., 5(7), pp. 552-555. (Pubitemid 43993077)
27. Chiarelli, P., and De Rossi, D., 1992, "Modelling and Mechanical Characterization of Thin Fibers of Contractile Polymer Hydrogels," J. Intell. Mater. Syst. Struct., 3(3), pp. 396-417. (Pubitemid 23564971)
28. Georges, P. C., Miller, W. J., Meaney, D. F., Sawyer, E. S., and Janmey, P. A., 2006, "Matrices With Compliance Comparable to that of Brain Tissue Select Neuronal Over Glial Growth in Mixed Cortical Cultures," Biophys. J., 90(80), pp. 3012-3018.
29. Hoyt, S. L., 1954, ASME Handbook: Metals Properties, McGraw-Hill, New York.
30. Pedersen, J. A., and Swartz, M. A., 2005, "Mechanobiology in the Third Dimension," Ann. Biomed. Eng., 33(11), pp. 1469-1490.
31. Peppas, N. A., and Merrill, E. W., 1977, "Crosslinked Poly (Vinyl Alcohol) Hydrogels as Swollen Elastic Networks," J. Appl. Polym. Sci., 21(7), pp. 1763-1770.
32. Anseth, K. S., Bowman, C. N., and Brannon-Peppas, L., 1996, "Mechanical Properties of Hydrogels and Their Experimental Determination," Biomaterials, 17(17), pp. 1647-1657. (Pubitemid 26278972)
33. Leung, L. Y., Tian, D., Brangwynne, C. P., Weitz, D. A., and Tschumperlin, D. J., 2007, "A New Microrheometric Approach Reveals Individual and Cooperative Roles for TGF-{Beta} 1 and IL-1 {Beta} in Fibroblast-Mediated Stiffening of Collagen Gels," FASEB J., 21(9), pp. 2064-2073.