Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility

Laboratory Investigation

Volumn 89, Issue 4, 2009, Pages 425-432

  Yamazaki, Ken ^a   Takamura, Masaaki ^b   Masugi, Yohei ^a   Mori, Taisuke ^a   Du, Wenlin ^a   Hibi, Taizo ^a   Hiraoka, Nobuyoshi ^c   Ohta, Tsutomu ^c   Ohki, Misao ^c   Hirohashi, Setsuo ^c   Sakamoto, Michiie ^a  

^a KEIO UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

CAP1; Metastasis; Microarray; Pancreatic cancer; Prognosis

Indexed keywords

ADENYLATE CYCLASE; CAP1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INVASION; CANCER PATIENT; CARCINOGENESIS; CELL MOTILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION PROFILING; GENE LOCATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LAMELLIPODIUM; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR XENOGRAFT;

AGED; ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETAL PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, SCID; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PSEUDOPODIA;

EID: 63449127854     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.5     Document Type: Article

References (35)

1. James TA, Gibbs JF. Pancreatic cancer screening: identifying premalignant disease. Future Oncol 2005;1:191-195.
2. Matsuda T, Marugame T, Kamo KI, et al. Cancer incidence and incidence rates in Japan in 2002: based on data from 11 populationbased cancer registries. Jpn J Clin Oncol 2008;38:641-648.
3. Warshaw A, Fernandez-del Castillo C. Pancreatic carcinoma. N Engl J Med 1992;326:455-465.
4. Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996;223:273-279.
5. Nakao A, Harada A, Nonami T, et al. Lymph node metastasis in carcinoma of the body and tail of the pancreas. Br J Surg 1997;84:1090-1092.
6. Sperti C, Pasquali C, Piccoli A, et al. Survival after resection for ductal adenocarcinoma of the pancreas. Br J Surg 1996;83:625-631.
7. Tsiotos GG, Farnell MB, Sarr MG. Are the results of pancreatectomy for pancreatic cancer improving. World J Surg 1999;23:913-919.
8. Scarpa A, Capelli P, Villaneuva A, et al. Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences. Int J Cancer 1994;57:167-171.
9. Moore PS, Sipos B, Orlandini S, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch 2001;439:798-802.
10. Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994;8:27-32.
11. Ruggeri B, Zhang SY, Caamano J, et al. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene 1992;7:1503-1511.
12. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
13. Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, et al. Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene 2002;21:4587-4594.
14. Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, et al. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002;160:1239-1249.
15. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 2003;63:8614-8622.
16. Logsdon CD, Simeone DM, Binkley C, et al. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003;63:2649-2657.
17. Tan ZJ, Hu XG, Cao GS, et al. Analysis of gene expression profile of pancreatic carcinoma using cDNA microarray. World J Gastroenterol 2003;9:818-823.
18. Grutzmann R, Foerder M, Alldinger I, et al. Gene expression profiles of microdissected pancreatic ductal adenocarcinoma. Virchows Arch 2003;443:508-517.
19. Loukopoulos P, Kanetaka K, Takamura M, et al. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 2004;29:193-203.
20. Hubberstey AV, Mottillo EP. Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. FASEB J 2002;16:487-499.
21. Loisel TP, Boujemaa R, Pantaloni D, et al. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature 1999;401:613-616.
22. Pollard TD, Blanchoin L, Mullins RD. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 2000;29:545-576.
23. Moriyama K, Yahara I. Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J Cell Sci 2002;115: 1591-1601.
24. Shibata R, Mori T, Du W, et al. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. Clin Cancer Res 2006;12:5363-5368.
25. Japanese Pancreas Society. Classification of Pancreatic Carcinoma, 2nd English edn. Kanehara and Co. Ltd: Tokyo, 2003.
26. Pignatelli M, Ansari TW, Gunter P, et al. Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J Pathol 1994;174: 243-248.
27. Kuniyasu H, Ellis LM, Evans DB, et al. Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. Clin Cancer Res 1999;5: 25-33.
28. Field J, Vojtek A, Ballester R, et al. Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell 1990;61:319-327.
29. Freeman NL, Chen Z, Horenstein J, et al. An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein. J Biol Chem 1995;270:5680-5685.
30. Gerst JE, Ferguson K, Vojtek A, et al. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Mol Cell Biol 1991;11:1248-1257.
31. Vojtek A, Haarer B, Field J, et al. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell 1991;66:497-505.
32. Noegel AA, Blau-Wasser R, Sultana H, et al. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell 2004;15:934-945.
33. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol 2000;10:964-973.
34. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol 2001;3:883-890.
35. Bertling E, Hotulainen P, Mattila PK, et al. Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol Biol Cell 2004;15:2324-2334.