Normal-like breast cells, but not breast cancer cells, recovered from treatment with N′,N″ -diethylnorspermine

Anti-Cancer Drugs

Volumn 20, Issue 4, 2009, Pages 230-237

  Myhre, Louise ^a   Aim, Kersti ^a   Johansson, Maria C ^b   Oredsson, Stina M ^a,b  

^a Cell and Organism Biology   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cell cycle; Flow cytometry; Human breast cancer; Human breast epithelium; Polyamine analog

Indexed keywords

CYCLIN A2; CYCLIN B1; CYCLIN E; N1,N11 DIETHYLNORSPERMINE; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ARTICLE; BREAST CANCER; BREAST CELL; BREAST EPITHELIUM; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL LABELING; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; BROMODEOXYURIDINE; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CYCLIN A; CYCLIN B; CYCLIN E; DNA; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; ONCOGENE PROTEINS; SPERMINE;

EID: 63449125495     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e328323fc98     Document Type: Article

References (33)

1. Sanchez I, Dynlacht BD. New insights into cyclins, CDKs, and cell cycle control. Semin Cell Oev Biol 2005; 16:311-321.
2. Sherr CJ. Cancer cell cycles. Science 1996; 274:1672-1677.
3. Caldon CE, Daly RJ, Sutherland RL, Musgrove EA. Cell cycle control in breast cancer cells. J Cell Biochem 2006; 97:261-274.
4. Nakayama K, Nakayama K. Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development. Bioessays 1998; 20:1020-1029.
5. Sherr CJ. The INK4a/ARF network in tumour suppression. Waf Rev Mol Cell Biol 2001; 2:731-737.
6. Thomas T, Thomas TJ. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2001; 58:244-258.
7. Oredsson SM. Polyamine dependence of normal cell-cycle progression. Biochem Soc Trans 2003; 31:366-370.
8. Fredlund JO, Johansson MC, Dahlberg E, Oredsson SM. Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells. Exp Cell Res 1995; 216:86-92.
9. Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 1988; 48:759-774.
10. Casero RA Jr, Marlon LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 2007; 6:373-390.
11. Seiler N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 2. Structural analogues and derivatives. Curr Drug Targets 2003; 4:565-585.
12. Seiler N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors. Curr Drug Targets 2003; 4:537-564.
13. Wolff AC, Armstrong DK, Fetting JH, Carducci MK, Riley CD, Bender JF, et al. A Phase II study of the polyamine analog N′,N″- diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. Clin Cancer Res 2003; 9:5922-5928.
14. Hahm HA, Ettinger DS, Bowling K, Hoker B, Chen TL, Zabelina Y, et al. Phase I study of N′,N″-diethylnorspermine in patients with non-small cell lung cancer. Clin Cancer Res 2002; 8:684-690.
15. Myhre L, Aim K, Hegardt C, Staff J, Jönsson G, Larsson S, et al. Different cell cycle kinetic effects of N′,N″- diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. Anti-Cancer Drugs 2008; 19:359-368.
16. Hegardt C, Johannsson OT, Oredsson SM. Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue ′,″-diethylnorspenmine. Eur J Biochem 2002; 269: 1033-1039.
17. Hoist CM, Oredsson SM. Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines. Toxicol In vitro 2005; 19:379-387.
18. Hoist CM, Frydman B, Marton LJ, Oredsson SM. Differential polyamine analogue effects in four human breast cancer cell lines. Toxicology 2006; 223:71-81.
19. Begg AC, McNally NJ, Shrieve DC, Karcher H. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 1985; 6:620-626.
20. Fredlund JO, Oredsson SM. Normal G,/S transition and prolonged S phase within one cell cycle after seeding cells in the presence of an ornithine decarboxylase inhibitor. Cell Prolrf 1996; 29:457-466.
21. Fredlund JO, Oredsson SM. Ordered cell cycle phase perturbations in Chinese hamster ovary cells treated with an S-adenosylmethionine decarboxylase inhibitor. Eur J Biochem 1997; 249:232-238.
22. Aim K, Berntsson PSH, Kramer DL, Porter CW, Oredsson SM. Treatment of cells with the polyamine analog N′,″-diethylnorspermine retards S phase progression within one cell cycle. Eur J Biochem 2000; 267:4157-4164.
23. Nasizadeh S, Myhre L, Thiman L, Aim K, Oredsson S, Persson L. Importance of polyamines in cell cycle kinetics as studied in a transgenic system. Exp Cell Res 2005; 308:254-264.
24. Johannsson OT, Staff S, Vallon-Christersson J, Kytola S, Gudjonsson T, Rennstam K, et al. Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier. Lab Invest 2003; 83:387-396.
25. Dolbeare F, Gratzner H, Pallavicini MG, Gray JW. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 1983; 80:5573-5577.
26. Schutte B, Reynders MM, van Assche CL, Hupperets PS, Bosman FT, Blijham GH. An improved method for the immunocytochemical detection of bromodeoxyuridine labeled nuclei using flow cytometry. Cytometry 1987; 8:372-376.
27. Van Erp PE, Brons PP, Boezeman JB, de Jongh GJ, Bauer FW. A rapid flow cytometric method for bivariate bromodeoxyuridine/DNA analysis using simultaneous proteolytic enzyme digestion and acid denaturation. Cytometry 1988; 9:627-630.
28. Seiler N, Knodgen B. Determination of amino acids by separation of their ion pairs with dodecyl sulphate. J Chromatogr 1985; 341:11-21.
29. Matsui I, Wiegand L, Pegg AE. Properties of spermidine N-acetyitransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine to putrescine. J Biol Chem 1981; 256:2454-2459.
30. Jonsson G, Staaf J, Olsson E, Heidenblad M, Vallon-Christersson J, Osoegawa K, et al. High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization. Genes Chromosomes Cancer 2007; 46:543-558.
31. Spurgers KB, Gold DL, Ccombes KR, Bohnenstiehl NL, Muffins B, Meyn RE, et al. Identification of cell cycle regulatory genes as principal targets of p53- mediated transcriptional repression. J Biol Chem 2006; 281:25134-25142.
32. Kramer DL, Vujcic S, Diegelman P, Alderfer J, Miller JT, Black JD, et al. Polyamine analogue induction of the p53-p21 WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells. Cancer Res 1999; 59:1278-1286.
33. Oredsson SM, Aim K, Dahlberg E, Hoist CM, Johansson VM, Myhre L, et al. Inhibition of cell proliferation and induction of apoptosis by ′,″-diethyl- norspermine-induced polyamine pool reduction. Biochem Soc Trans 2007; 35:405-409.