메뉴 건너뛰기




Volumn 44, Issue 5, 2009, Pages 785-794

Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading

Author keywords

Bone formation; HB GAM (pleiotrophin); Immobilization; Knockout; Osteocyte

Indexed keywords

PLEIOTROPHIN;

EID: 63449105137     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.01.004     Document Type: Article
Times cited : (45)

References (53)
  • 1
    • 0034953744 scopus 로고    scopus 로고
    • Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule
    • Amet L.E., Lauri S.E., Hienola A., Croll S.D., Lu Y., Levorse J.M., et al. Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol. Cell. Neurosci. 17 (2001) 1014-1024
    • (2001) Mol. Cell. Neurosci. , vol.17 , pp. 1014-1024
    • Amet, L.E.1    Lauri, S.E.2    Hienola, A.3    Croll, S.D.4    Lu, Y.5    Levorse, J.M.6
  • 2
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses
    • Amling M., Priemel M., Holzmann T., Chapin K., Rueger J.M., Baron R., et al. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140 (1999) 4982-4987
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1    Priemel, M.2    Holzmann, T.3    Chapin, K.4    Rueger, J.M.5    Baron, R.6
  • 3
    • 37249057821 scopus 로고    scopus 로고
    • Osteocytes as dynamic multifunctional cells
    • Bonewald L.F. Osteocytes as dynamic multifunctional cells. Ann. N. Y. Acad. Sci. 1116 (2007) 281-290
    • (2007) Ann. N. Y. Acad. Sci. , vol.1116 , pp. 281-290
    • Bonewald, L.F.1
  • 4
    • 0032055026 scopus 로고    scopus 로고
    • Glutamate receptors are expressed by bone cells and are involved in bone resorption
    • Chenu C., Serre C.M., Raynal C., Burt-Pichat B., and Delmas P.D. Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 22 (1998) 295-299
    • (1998) Bone , vol.22 , pp. 295-299
    • Chenu, C.1    Serre, C.M.2    Raynal, C.3    Burt-Pichat, B.4    Delmas, P.D.5
  • 5
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 6
    • 0027447376 scopus 로고
    • Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo
    • Dallas S.L., Zaman G., Pead M.J., and Lanyon L.E. Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J. Bone Miner. Res. 8 (1993) 251-259
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 251-259
    • Dallas, S.L.1    Zaman, G.2    Pead, M.J.3    Lanyon, L.E.4
  • 7
    • 0027739983 scopus 로고
    • Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment
    • Gieffers C., Engelhardt W., Brenzel G., Matsuishi T., and Frey J. Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment. Eur. J. Cell Biol. 62 (1993) 352-361
    • (1993) Eur. J. Cell Biol. , vol.62 , pp. 352-361
    • Gieffers, C.1    Engelhardt, W.2    Brenzel, G.3    Matsuishi, T.4    Frey, J.5
  • 8
    • 1542299031 scopus 로고    scopus 로고
    • Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts
    • Heino T.J., Hentunen T.A., and Vaananen H.K. Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts. Exp. Cell Res. 294 (2004) 458-468
    • (2004) Exp. Cell Res. , vol.294 , pp. 458-468
    • Heino, T.J.1    Hentunen, T.A.2    Vaananen, H.K.3
  • 9
    • 2342650895 scopus 로고    scopus 로고
    • HB-GAM inhibits proliferation and enhances differentiation of neural stem cells
    • Hienola A., Pekkanen M., Raulo E., Vanttola P., and Rauvala H. HB-GAM inhibits proliferation and enhances differentiation of neural stem cells. Mol. Cell. Neurosci. 26 (2004) 75-88
    • (2004) Mol. Cell. Neurosci. , vol.26 , pp. 75-88
    • Hienola, A.1    Pekkanen, M.2    Raulo, E.3    Vanttola, P.4    Rauvala, H.5
  • 10
    • 33747199616 scopus 로고    scopus 로고
    • N-syndecan deficiency impairs neural migration in brain
    • Hienola A., Tumova S., Kulesskiy E., and Rauvala H. N-syndecan deficiency impairs neural migration in brain. J. Cell Biol. 174 (2006) 569-580
    • (2006) J. Cell Biol. , vol.174 , pp. 569-580
    • Hienola, A.1    Tumova, S.2    Kulesskiy, E.3    Rauvala, H.4
  • 11
    • 0032539011 scopus 로고    scopus 로고
    • Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM)
    • Imai S., Kaksonen M., Raulo E., Kinnunen T., Fages C., Meng X., et al. Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). J. Cell Biol. 143 (1998) 1113-1128
    • (1998) J. Cell Biol. , vol.143 , pp. 1113-1128
    • Imai, S.1    Kaksonen, M.2    Raulo, E.3    Kinnunen, T.4    Fages, C.5    Meng, X.6
  • 12
    • 0030915460 scopus 로고    scopus 로고
    • Efferent targets of osseous CGRP-immunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat: an ultramorphological study on their terminal-target relations
    • Imai S., Rauvala H., Konttinen Y.T., Tokunaga T., Maeda T., Hukuda S., et al. Efferent targets of osseous CGRP-immunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat: an ultramorphological study on their terminal-target relations. J. Bone Miner. Res. 12 (1997) 1018-1027
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1018-1027
    • Imai, S.1    Rauvala, H.2    Konttinen, Y.T.3    Tokunaga, T.4    Maeda, T.5    Hukuda, S.6
  • 13
    • 0033145332 scopus 로고    scopus 로고
    • Animal models of immobilization osteopenia
    • Jee W.S., and Ma Y. Animal models of immobilization osteopenia. Morphologie 83 (1999) 25-34
    • (1999) Morphologie , vol.83 , pp. 25-34
    • Jee, W.S.1    Ma, Y.2
  • 14
    • 34249827264 scopus 로고    scopus 로고
    • Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress
    • Jiang J.X., Siller-Jackson A.J., and Burra S. Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front. Biosci. 12 (2007) 1450-1462
    • (2007) Front. Biosci. , vol.12 , pp. 1450-1462
    • Jiang, J.X.1    Siller-Jackson, A.J.2    Burra, S.3
  • 15
    • 0035130601 scopus 로고    scopus 로고
    • A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy
    • Kamioka H., Honjo T., and Takano-Yamamoto T. A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. Bone 28 (2001) 145-149
    • (2001) Bone , vol.28 , pp. 145-149
    • Kamioka, H.1    Honjo, T.2    Takano-Yamamoto, T.3
  • 16
    • 0031035011 scopus 로고    scopus 로고
    • Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells
    • Klein-Nulend J., Burger E.H., Semeins C.M., Raisz L.G., and Pilbeam C.C. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. J. Bone Miner. Res. 12 (1997) 45-51
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 45-51
    • Klein-Nulend, J.1    Burger, E.H.2    Semeins, C.M.3    Raisz, L.G.4    Pilbeam, C.C.5
  • 18
    • 0034017485 scopus 로고    scopus 로고
    • Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice
    • Kodama Y., Umemura Y., Nagasawa S., Beamer W.G., Donahue L.R., Rosen C.R., et al. Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice. Calcif. Tissue Int. 66 (2000) 298-306
    • (2000) Calcif. Tissue Int. , vol.66 , pp. 298-306
    • Kodama, Y.1    Umemura, Y.2    Nagasawa, S.3    Beamer, W.G.4    Donahue, L.R.5    Rosen, C.R.6
  • 20
    • 0025615372 scopus 로고
    • Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
    • Li Y.S., Milner P.G., Chauhan A.K., Watson M.A., Hoffman R.M., Kodner C.M., et al. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250 (1990) 1690-1694
    • (1990) Science , vol.250 , pp. 1690-1694
    • Li, Y.S.1    Milner, P.G.2    Chauhan, A.K.3    Watson, M.A.4    Hoffman, R.M.5    Kodner, C.M.6
  • 22
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) Method
    • Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) Method. Methods 25 (2001) 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 0002767351 scopus 로고    scopus 로고
    • The Structure and Development of Bone
    • Bilezikian J., Raisz L., and Rodan G. (Eds), Academic Press, San Diego
    • Marks S., and Odgren P. The Structure and Development of Bone. In: Bilezikian J., Raisz L., and Rodan G. (Eds). Principles of Bone Biology vol. 1 (2002), Academic Press, San Diego 3-8
    • (2002) Principles of Bone Biology , vol.1 , pp. 3-8
    • Marks, S.1    Odgren, P.2
  • 24
    • 0027400975 scopus 로고
    • Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone
    • McKee M.D., Farach-Carson M.C., Butler W.T., Hauschka P.V., and Nanci A. Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone. J. Bone Miner. Res. 8 (1993) 485-496
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 485-496
    • McKee, M.D.1    Farach-Carson, M.C.2    Butler, W.T.3    Hauschka, P.V.4    Nanci, A.5
  • 25
    • 0025162762 scopus 로고
    • Molecular cloning of the 18-kDa growth-associated protein of developing brain
    • Merenmies J., and Rauvala H. Molecular cloning of the 18-kDa growth-associated protein of developing brain. J. Biol. Chem. 265 (1990) 16721-16724
    • (1990) J. Biol. Chem. , vol.265 , pp. 16721-16724
    • Merenmies, J.1    Rauvala, H.2
  • 26
    • 0036739307 scopus 로고    scopus 로고
    • Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis
    • Muramatsu T. Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J. Biochem. 132 (2002) 359-371
    • (2002) J. Biochem. , vol.132 , pp. 359-371
    • Muramatsu, T.1
  • 27
    • 0034192758 scopus 로고    scopus 로고
    • Molecular events caused by mechanical stress in bone
    • Nomura S., and Takano-Yamamoto T. Molecular events caused by mechanical stress in bone. Matrix Biol. 19 (2000) 91-96
    • (2000) Matrix Biol. , vol.19 , pp. 91-96
    • Nomura, S.1    Takano-Yamamoto, T.2
  • 28
    • 17144438059 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover
    • Ogata N., Chikazu D., Kubota N., Terauchi Y., Tobe K., Azuma Y., et al. Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J. Clin. Invest. 105 (2000) 935-943
    • (2000) J. Clin. Invest. , vol.105 , pp. 935-943
    • Ogata, N.1    Chikazu, D.2    Kubota, N.3    Terauchi, Y.4    Tobe, K.5    Azuma, Y.6
  • 29
    • 0042744009 scopus 로고    scopus 로고
    • Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media
    • Ogata T. Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media. Am. J. Physiol., Cell Physiol. 285 (2003) C425-C432
    • (2003) Am. J. Physiol., Cell Physiol. , vol.285
    • Ogata, T.1
  • 30
    • 0023488581 scopus 로고
    • Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2 (1987) 595-610
    • (1987) J. Bone Miner. Res. , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6
  • 31
    • 0032101276 scopus 로고    scopus 로고
    • Expression of an N-methyl-d-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone
    • Patton A.J., Genever P.G., Birch M.A., Suva L.J., and Skerry T.M. Expression of an N-methyl-d-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. Bone 22 (1998) 645-649
    • (1998) Bone , vol.22 , pp. 645-649
    • Patton, A.J.1    Genever, P.G.2    Birch, M.A.3    Suva, L.J.4    Skerry, T.M.5
  • 32
    • 0036318503 scopus 로고    scopus 로고
    • Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice
    • Pavlov I., Voikar V., Kaksonen M., Lauri S.E., Hienola A., Taira T., et al. Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol. Cell. Neurosci. 20 (2002) 330-342
    • (2002) Mol. Cell. Neurosci. , vol.20 , pp. 330-342
    • Pavlov, I.1    Voikar, V.2    Kaksonen, M.3    Lauri, S.E.4    Hienola, A.5    Taira, T.6
  • 33
    • 0028216755 scopus 로고
    • Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
    • Raulo E., Chernousov M.A., Carey D.J., Nolo R., and Rauvala H. Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). J. Biol. Chem. 269 (1994) 12999-13004
    • (1994) J. Biol. Chem. , vol.269 , pp. 12999-13004
    • Raulo, E.1    Chernousov, M.A.2    Carey, D.J.3    Nolo, R.4    Rauvala, H.5
  • 34
    • 0026648538 scopus 로고
    • Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein
    • Raulo E., Julkunen I., Merenmies J., Pihlaskari R., and Rauvala H. Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein. J. Biol. Chem. 267 (1992) 11408-11416
    • (1992) J. Biol. Chem. , vol.267 , pp. 11408-11416
    • Raulo, E.1    Julkunen, I.2    Merenmies, J.3    Pihlaskari, R.4    Rauvala, H.5
  • 35
    • 29244488239 scopus 로고    scopus 로고
    • The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons
    • Raulo E., Tumova S., Pavlov I., Pekkanen M., Hienola A., Klankki E., et al. The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons. J. Biol. Chem. 280 (2005) 41576-41583
    • (2005) J. Biol. Chem. , vol.280 , pp. 41576-41583
    • Raulo, E.1    Tumova, S.2    Pavlov, I.3    Pekkanen, M.4    Hienola, A.5    Klankki, E.6
  • 36
    • 0024317792 scopus 로고
    • An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors
    • Rauvala H. An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J. 8 (1989) 2933-2941
    • (1989) EMBO J. , vol.8 , pp. 2933-2941
    • Rauvala, H.1
  • 37
    • 0033813705 scopus 로고    scopus 로고
    • Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility
    • Rauvala H., Huttunen H.J., Fages C., Kaksonen M., Kinnunen T., Imai S., et al. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Matrix Biol. 19 (2000) 377-387
    • (2000) Matrix Biol. , vol.19 , pp. 377-387
    • Rauvala, H.1    Huttunen, H.J.2    Fages, C.3    Kaksonen, M.4    Kinnunen, T.5    Imai, S.6
  • 38
    • 33846026749 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    • Robinson J.A., Chatterjee-Kishore M., Yaworsky P.J., Cullen D.M., Zhao W., Li C., et al. Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J. Biol. Chem. 281 (2006) 31720-31728
    • (2006) J. Biol. Chem. , vol.281 , pp. 31720-31728
    • Robinson, J.A.1    Chatterjee-Kishore, M.2    Yaworsky, P.J.3    Cullen, D.M.4    Zhao, W.5    Li, C.6
  • 39
  • 40
    • 0029878133 scopus 로고    scopus 로고
    • Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice
    • Sakai A., Nakamura T., Tsurukami H., Okazaki R., Nishida S., Tanaka Y., et al. Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice. Bone 18 (1996) 479-486
    • (1996) Bone , vol.18 , pp. 479-486
    • Sakai, A.1    Nakamura, T.2    Tsurukami, H.3    Okazaki, R.4    Nishida, S.5    Tanaka, Y.6
  • 41
    • 0031792839 scopus 로고    scopus 로고
    • Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: modulation by cation channel blockades
    • Sakai K., Mohtai M., and Iwamoto Y. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: modulation by cation channel blockades. Calcif. Tissue Int. 63 (1998) 515-520
    • (1998) Calcif. Tissue Int. , vol.63 , pp. 515-520
    • Sakai, K.1    Mohtai, M.2    Iwamoto, Y.3
  • 42
    • 50249185592 scopus 로고    scopus 로고
    • Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones
    • Sample S.J., Behan M., Smith L., Oldenhoff W.E., Markel M.D., Kalscheur V.L., et al. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J. Bone Miner. Res. 23 (2008) 1372-1381
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 1372-1381
    • Sample, S.J.1    Behan, M.2    Smith, L.3    Oldenhoff, W.E.4    Markel, M.D.5    Kalscheur, V.L.6
  • 43
    • 39149139320 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in mice
    • Schinke T., Gebauer M., Schilling A.F., Lamprianou S., Priemel M., Mueldner C., et al. The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in mice. Bone 42 (2008) 524-534
    • (2008) Bone , vol.42 , pp. 524-534
    • Schinke, T.1    Gebauer, M.2    Schilling, A.F.3    Lamprianou, S.4    Priemel, M.5    Mueldner, C.6
  • 44
    • 0024326174 scopus 로고
    • Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo
    • Skerry T.M., Bitensky L., Chayen J., and Lanyon L.E. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo. J. Bone Miner. Res. 4 (1989) 783-788
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 783-788
    • Skerry, T.M.1    Bitensky, L.2    Chayen, J.3    Lanyon, L.E.4
  • 45
    • 0035313223 scopus 로고    scopus 로고
    • Glutamate signalling in non-neuronal tissues
    • Skerry T.M., and Genever P.G. Glutamate signalling in non-neuronal tissues. Trends Pharmacol. Sci. 22 (2001) 174-181
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 174-181
    • Skerry, T.M.1    Genever, P.G.2
  • 46
    • 0036830216 scopus 로고    scopus 로고
    • Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation
    • Tare R.S., Oreffo R.O., Clarke N.M., and Roach H.I. Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J. Bone Miner. Res. 17 (2002) 2009-2020
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 2009-2020
    • Tare, R.S.1    Oreffo, R.O.2    Clarke, N.M.3    Roach, H.I.4
  • 51
    • 28044434415 scopus 로고    scopus 로고
    • Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice
    • Xing W., Baylink D., Kesavan C., Hu Y., Kapoor S., Chadwick R.B., et al. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. J. Cell. Biochem. 96 (2005) 1049-1060
    • (2005) J. Cell. Biochem. , vol.96 , pp. 1049-1060
    • Xing, W.1    Baylink, D.2    Kesavan, C.3    Hu, Y.4    Kapoor, S.5    Chadwick, R.B.6
  • 52
    • 0037215657 scopus 로고    scopus 로고
    • Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering
    • Yang X., Tare R.S., Partridge K.A., Roach H.I., Clarke N.M., Howdle S.M., et al. Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J. Bone Miner. Res. 18 (2003) 47-57
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 47-57
    • Yang, X.1    Tare, R.S.2    Partridge, K.A.3    Roach, H.I.4    Clarke, N.M.5    Howdle, S.M.6
  • 53
    • 0029818710 scopus 로고    scopus 로고
    • Time responses of cancellous and cortical bones to sciatic neurectomy in growing female rats
    • Zeng Q.Q., Jee W.S., Bigornia A.E., King Jr. J.G., D'Souza S.M., Li X.J., et al. Time responses of cancellous and cortical bones to sciatic neurectomy in growing female rats. Bone 19 (1996) 13-21
    • (1996) Bone , vol.19 , pp. 13-21
    • Zeng, Q.Q.1    Jee, W.S.2    Bigornia, A.E.3    King Jr., J.G.4    D'Souza, S.M.5    Li, X.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.