메뉴 건너뛰기




Volumn 24, Issue 2, 2009, Pages 83-89

Genetics and alzheimer's disease;Genética y enfermedad de alzheimer

Author keywords

Alzheimer disease; APOE; Environmental factors; Genetics

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2;

EID: 63449103066     PISSN: 02134853     EISSN: 15781968     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (67)
  • 1
    • 0035826782 scopus 로고    scopus 로고
    • Practice parameter: Diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Knopman DS, Dekosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1143-53.
    • (2001) Neurology , vol.56 , pp. 1143-1153
    • Knopman, D.S.1    Dekosky, S.T.2    Cummings, J.L.3    Chui, H.4    Corey-Bloom, J.5    Relkin, N.6
  • 2
    • 0034643928 scopus 로고    scopus 로고
    • Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group
    • Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di CA, Breteler MM, et al. Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000;54:S4-S9.
    • (2000) Neurology , vol.54
    • Lobo, A.1    Launer, L.J.2    Fratiglioni, L.3    Andersen, K.4    Di, C.A.5    Breteler, M.M.6
  • 3
    • 0028914970 scopus 로고    scopus 로고
    • Ott A, Breteler MM, Van HF, Claus JJ, Van der Cammen TJ, Grobbee DE, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 1995;310:970-3.
    • Ott A, Breteler MM, Van HF, Claus JJ, Van der Cammen TJ, Grobbee DE, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 1995;310:970-3.
  • 4
    • 0038636351 scopus 로고    scopus 로고
    • Prevalence of dementia and Alzheimer's disease among subjects aged 75 years or over: Updated results of the PAQUID cohort
    • Ramaroson H, Helmer C, Barberger-Gateau P, Letenneur L, Dartigues JF. Prevalence of dementia and Alzheimer's disease among subjects aged 75 years or over: updated results of the PAQUID cohort. Rev Neurol (Paris) 2003;159:405-11.
    • (2003) Rev Neurol (Paris) , vol.159 , pp. 405-411
    • Ramaroson, H.1    Helmer, C.2    Barberger-Gateau, P.3    Letenneur, L.4    Dartigues, J.F.5
  • 5
    • 0032901080 scopus 로고    scopus 로고
    • Rates and risk factors for dementia and Alzheimer's disease: Results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia
    • Launer LJ, Andersen K, Dewey ME, Letenneur L, Ott A, Amaducci LA, et al. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology 1999;52:78-84.
    • (1999) Neurology , vol.52 , pp. 78-84
    • Launer, L.J.1    Andersen, K.2    Dewey, M.E.3    Letenneur, L.4    Ott, A.5    Amaducci, L.A.6
  • 7
    • 84869274185 scopus 로고    scopus 로고
    • editor. Textbook of neurogenetics. Madrid: Díaz de Santos, 2 0 07; p
    • Jiménez-Escrig A, Barón M. Genetic of dementia. En: Jiménez-Escrig A, editor. Textbook of neurogenetics. Madrid: Díaz de Santos, 2 0 07; p. 213-39.
    • Genetic of dementia , pp. 213-239
    • Jiménez-Escrig, A.1    Barón, M.2
  • 9
    • 20444504698 scopus 로고    scopus 로고
    • The genetic epidemiology of neurodegenerative disease
    • Bertram L, Tanzi RE. The genetic epidemiology of neurodegenerative disease. J Clin Invest 2005;115:1449-57.
    • (2005) J Clin Invest , vol.115 , pp. 1449-1457
    • Bertram, L.1    Tanzi, R.E.2
  • 10
    • 84869269244 scopus 로고    scopus 로고
    • Aspectos neurogenéticos. En: Manual de demencias. Barcelona: Prous
    • Baiget Bastos M. Aspectos neurogenéticos. En: Manual de demencias. Barcelona: Prous Science, 1996; p. 106-4.
    • (1996) Science , pp. 106-114
    • Baiget Bastos, M.1
  • 11
    • 0033600301 scopus 로고    scopus 로고
    • Molecular basis of the neurodegenerative disorders
    • Martín JB. Molecular basis of the neurodegenerative disorders. N Engl J Med 1999;340:1970-80.
    • (1999) N Engl J Med , vol.340 , pp. 1970-1980
    • Martín, J.B.1
  • 12
    • 0022614193 scopus 로고
    • Down's syndrome and Alzheimer's disease: A review
    • Oliver C, Holland AJ. Down's syndrome and Alzheimer's disease: a review. Psychol Med 1986;1 6:307-22.
    • (1986) Psychol Med , vol.1 , Issue.6 , pp. 307-322
    • Oliver, C.1    Holland, A.J.2
  • 13
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 1987;235:877-80.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 15
    • 0027442581 scopus 로고
    • Heterogeneity in Alzheimer's disease
    • Hardy J, Duff K. Heterogeneity in Alzheimer's disease. Ann Med 1993;25: 437-40.
    • (1993) Ann Med , vol.25 , pp. 437-440
    • Hardy, J.1    Duff, K.2
  • 16
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-6.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 17
    • 0026648493 scopus 로고
    • Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases
    • Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, et al. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet 1992;51:273-82.
    • (1992) Am J Hum Genet , vol.51 , pp. 273-282
    • Tanzi, R.E.1    Vaula, G.2    Romano, D.M.3    Mortilla, M.4    Huang, T.L.5    Tupler, R.G.6
  • 19
    • 0025219026 scopus 로고
    • Genomic organization of the human amyloid beta-protein precursor gene
    • Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y. Genomic organization of the human amyloid beta-protein precursor gene. Gene 1990;87:257-63.
    • (1990) Gene , vol.87 , pp. 257-263
    • Yoshikai, S.1    Sasaki, H.2    Doh-ura, K.3    Furuya, H.4    Sakaki, Y.5
  • 20
    • 0024810385 scopus 로고
    • The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion
    • Schubert D, Jin LW, Saitoh T, Cole G. The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion. Neuron 1989;3:689-94.
    • (1989) Neuron , vol.3 , pp. 689-694
    • Schubert, D.1    Jin, L.W.2    Saitoh, T.3    Cole, G.4
  • 22
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
    • Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, et al. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992;359:325-7.
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1    Vigo-Pelfrey, C.2    Esch, F.3    Lee, M.4    Dovey, H.5    Davis, D.6
  • 23
    • 0026545684 scopus 로고
    • An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence
    • Anderson JP, Chen Y, Kim KS, Robakis NK. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. J Neurochem 1992;59:2328-31.
    • (1992) J Neurochem , vol.59 , pp. 2328-2331
    • Anderson, J.P.1    Chen, Y.2    Kim, K.S.3    Robakis, N.K.4
  • 24
    • 18844378852 scopus 로고    scopus 로고
    • Presenilin function and gamma-secretase activity
    • Brunkan AL, Goate AM. Presenilin function and gamma-secretase activity. J Neurochem 2005;93:769-92.
    • (2005) J Neurochem , vol.93 , pp. 769-792
    • Brunkan, A.L.1    Goate, A.M.2
  • 25
    • 0027024651 scopus 로고    scopus 로고
    • Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Díaz P, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet 1992;2:340-2.
    • Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Díaz P, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet 1992;2:340-2.
  • 26
    • 0029115555 scopus 로고
    • The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group
    • The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group. Nat Genet 1995;11:219-22.
    • (1995) Nat Genet , vol.11 , pp. 219-222
  • 27
    • 10744221940 scopus 로고    scopus 로고
    • Zekanowski C, Styczynska M, Peplonska B, Gabryelewicz T, Religa D, Ilkowski J, et al. Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland. Exp Neurol 2003;184:991-6.
    • Zekanowski C, Styczynska M, Peplonska B, Gabryelewicz T, Religa D, Ilkowski J, et al. Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland. Exp Neurol 2003;184:991-6.
  • 28
    • 33646126924 scopus 로고    scopus 로고
    • A decade of modeling Alzheimer's disease in transgenic mice
    • McGowan E, Eriksen J, Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet 2006;22:281-9.
    • (2006) Trends Genet , vol.22 , pp. 281-289
    • McGowan, E.1    Eriksen, J.2    Hutton, M.3
  • 29
    • 34047272692 scopus 로고    scopus 로고
    • Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry 2007;68:613-8.
    • Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry 2007;68:613-8.
  • 30
    • 0345378517 scopus 로고
    • Biosíntesis de lípidos
    • Omega, editor
    • Lehninger AL NDCC. Biosíntesis de lípidos. En: Omega, editor. Principios de Bioquímica 1993:642-87.
    • (1993) Principios de Bioquímica , pp. 642-687
    • Lehninger, A.N.1
  • 31
    • 0036592640 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease: The protective effects of ApoE2 and E3
    • Rebeck GW, Kindy M, LaDu MJ. Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3. J Alzheimers Dis 2002;4:145-54.
    • (2002) J Alzheimers Dis , vol.4 , pp. 145-154
    • Rebeck, G.W.1    Kindy, M.2    LaDu, M.J.3
  • 32
    • 11444251445 scopus 로고    scopus 로고
    • E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    • Poirier J. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease. Neurobiol Aging 2005;26:355-61.
    • (2005) Neurobiol Aging , vol.26 , pp. 355-361
    • Apolipoprotein, P.J.1
  • 33
  • 34
    • 0011959766 scopus 로고
    • Apolipoprotein E immunoreactivity is increased in amyloid deposits of Alzsheimer's disease, but not pathological aging or diffuse Lewy body disease
    • Mortimer A WBWH, editor, London: Martin Dunitz
    • Dickson DW, Ivanushkin A. Apolipoprotein E immunoreactivity is increased in amyloid deposits of Alzsheimer's disease, but not pathological aging or diffuse Lewy body disease. En: Mortimer A WBWH, editor. Research advances in alzheimer's disease and related disorders. London: Martin Dunitz, 1995: p. 371-83.
    • (1995) Research advances in alzheimer's disease and related disorders , pp. 371-383
    • Dickson, D.W.1    Ivanushkin, A.2
  • 35
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 36
    • 12044254746 scopus 로고    scopus 로고
    • Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Peri-cak-Vance M, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:8098-102.
    • Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Peri-cak-Vance M, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:8098-102.
  • 37
    • 37648999282 scopus 로고    scopus 로고
    • Li Y, Grupe A. Genetics of late-onset Alzheimer's disease: progress and prospect. Pharmacogenomics 2007;8:1747-55.
    • Li Y, Grupe A. Genetics of late-onset Alzheimer's disease: progress and prospect. Pharmacogenomics 2007;8:1747-55.
  • 38
    • 0021354819 scopus 로고
    • Polymorphism at the apoprotein-E locus in relation to risk of coronary disease
    • Cumming AM, Robertson FW. Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin Genet 1984;25:310-3.
    • (1984) Clin Genet , vol.25 , pp. 310-313
    • Cumming, A.M.1    Robertson, F.W.2
  • 39
    • 0028305380 scopus 로고    scopus 로고
    • Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gas-kell PC, Jr., et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994;7:180-4.
    • Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gas-kell PC, Jr., et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994;7:180-4.
  • 40
    • 0028178047 scopus 로고
    • Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region
    • Chartier-Harlin MC, Parfitt M, Legrain S, Perez-Tur J, Brousseau T, Evans A, et al. Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet 1994;3:569-74.
    • (1994) Hum Mol Genet , vol.3 , pp. 569-574
    • Chartier-Harlin, M.C.1    Parfitt, M.2    Legrain, S.3    Perez-Tur, J.4    Brousseau, T.5    Evans, A.6
  • 41
    • 0019379410 scopus 로고
    • Human apolipoprotein E isoprotein subclasses are genetically determined
    • Zannis VI, Just PW, Breslow JL. Human apolipoprotein E isoprotein subclasses are genetically determined. Am J Hum Genet 1981;33:11-24.
    • (1981) Am J Hum Genet , vol.33 , pp. 11-24
    • Zannis, V.I.1    Just, P.W.2    Breslow, J.L.3
  • 42
    • 0028167195 scopus 로고
    • ApoE epsilon 4 allelic association with Alzheimer's disease: Independent confirmation using denaturing gradient gel electro- phoresis
    • Peacock ML, Fink JK. ApoE epsilon 4 allelic association with Alzheimer's disease: independent confirmation using denaturing gradient gel electro- phoresis. Neurology 1994;44:339-41.
    • (1994) Neurology , vol.44 , pp. 339-341
    • Peacock, M.L.1    Fink, J.K.2
  • 43
    • 0033799573 scopus 로고    scopus 로고
    • Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
    • Fullerton SM, Clark AG, Weiss KM, Nickerson DA, Taylor SL, Stengard JH, et al. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet 2000;67:881-900.
    • (2000) Am J Hum Genet , vol.67 , pp. 881-900
    • Fullerton, S.M.1    Clark, A.G.2    Weiss, K.M.3    Nickerson, D.A.4    Taylor, S.L.5    Stengard, J.H.6
  • 44
    • 63449099135 scopus 로고    scopus 로고
    • Wahlund L. Challenge of the current diagnostic criteria for Alzheimer's Disease. K Iqbal and B Winblad. Alzheimer's Disease and related disorders: research advances. Bucharest: Ana Asian Intl Acad of Aging 2003; p. 103-110.
    • Wahlund L. Challenge of the current diagnostic criteria for Alzheimer's Disease. K Iqbal and B Winblad. Alzheimer's Disease and related disorders: research advances. Bucharest: Ana Asian Intl Acad of Aging 2003; p. 103-110.
  • 46
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
    • Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology 1995;45:1092-6.
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3    Schellenberg, G.D.4    Yu, C.5    Larson, E.B.6
  • 47
    • 0028167193 scopus 로고    scopus 로고
    • Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P. Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology 1994;44:342-4.
    • Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P. Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology 1994;44:342-4.
  • 48
    • 63449135707 scopus 로고    scopus 로고
    • Factores geneticos y ambientales que pueden influir en la forma senil de la enfermedad de Alzheimer: Estudio de casos y controles anidado.
    • Bufill E, Bartes A, Moral A, Casadevall T, Codinachs M, Zapater E, et al. Factores geneticos y ambientales que pueden influir en la forma senil de la enfermedad de Alzheimer: estudio de casos y controles anidado. Neurología 2009;24:108-112.
    • (2009) Neurología , vol.24 , pp. 108-112
    • Bufill, E.1    Bartes, A.2    Moral, A.3    Casadevall, T.4    Codinachs, M.5    Zapater, E.6
  • 49
    • 0029664414 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study
    • Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A, et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study. Neurology 1996;46:673-7.
    • (1996) Neurology , vol.46 , pp. 673-677
    • Myers, R.H.1    Schaefer, E.J.2    Wilson, P.W.3    D'Agostino, R.4    Ordovas, J.M.5    Espino, A.6
  • 50
    • 0034643749 scopus 로고    scopus 로고
    • Small BJ, Graves AB, McEvoy CL, Crawford FC, Mullan M, Mortimer JA. Is APOE-epsilon4 a risk factor for cognitive impairment in normal aging? Neurology 2000;54:2082-8.
    • Small BJ, Graves AB, McEvoy CL, Crawford FC, Mullan M, Mortimer JA. Is APOE-epsilon4 a risk factor for cognitive impairment in normal aging? Neurology 2000;54:2082-8.
  • 51
    • 0034711620 scopus 로고    scopus 로고
    • APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old
    • Juva K, Verkkoniemi A, Viramo P, Polvikoski T, Kainulainen K, Kontula K, et al. APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old. Neurology 2000;54:412-5.
    • (2000) Neurology , vol.54 , pp. 412-415
    • Juva, K.1    Verkkoniemi, A.2    Viramo, P.3    Polvikoski, T.4    Kainulainen, K.5    Kontula, K.6
  • 52
    • 0034711696 scopus 로고    scopus 로고
    • E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease
    • Corey-Bloom J, Tiraboschi P, Hansen LA, Alford M, Schoos B, Sabbagh MN, et al. E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease. Neurology 2000;54:403-6.
    • (2000) Neurology , vol.54 , pp. 403-406
    • Corey-Bloom, J.1    Tiraboschi, P.2    Hansen, L.A.3    Alford, M.4    Schoos, B.5    Sabbagh, M.N.6
  • 53
    • 0033595026 scopus 로고    scopus 로고
    • APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: The Cache County Study
    • Breitner JC, Wyse BW, Anthony JC, Welsh-Bohmer KA, Steffens DC, Norton MC, et al. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology 1999;53:321-31.
    • (1999) Neurology , vol.53 , pp. 321-331
    • Breitner, J.C.1    Wyse, B.W.2    Anthony, J.C.3    Welsh-Bohmer, K.A.4    Steffens, D.C.5    Norton, M.C.6
  • 54
    • 45449085214 scopus 로고    scopus 로고
    • No association of SORL1 SNPs with Alzheimer's disease
    • Minster RL, Dekosky ST, Kamboh MI. No association of SORL1 SNPs with Alzheimer's disease. Neurosci Lett 2008;440:190-2.
    • (2008) Neurosci Lett , vol.440 , pp. 190-192
    • Minster, R.L.1    Dekosky, S.T.2    Kamboh, M.I.3
  • 55
    • 34247177933 scopus 로고    scopus 로고
    • The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    • Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y, et al. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol 2007;64:501-6.
    • (2007) Arch Neurol , vol.64 , pp. 501-506
    • Lee, J.H.1    Cheng, R.2    Schupf, N.3    Manly, J.4    Lantigua, R.5    Stern, Y.6
  • 56
    • 40849102705 scopus 로고    scopus 로고
    • Association study of the GAB2 gene with the risk of developing Alzheimer's disease
    • Chapuis J, Hannequin D, Pasquier F, Bentham P, Brice A, Leber I, et al. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol Dis 2008;30:103-6.
    • (2008) Neurobiol Dis , vol.30 , pp. 103-106
    • Chapuis, J.1    Hannequin, D.2    Pasquier, F.3    Bentham, P.4    Brice, A.5    Leber, I.6
  • 58
    • 29444442794 scopus 로고    scopus 로고
    • Rovelet-Lecrux A, Hannequin D, Raux G, Le MN, Laquerriere A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006;38:24-6.
    • Rovelet-Lecrux A, Hannequin D, Raux G, Le MN, Laquerriere A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006;38:24-6.
  • 59
    • 0031817594 scopus 로고    scopus 로고
    • Drigalenko E, Poduslo S, Elston R. Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease. Neurology 1998;51:131-5.
    • Drigalenko E, Poduslo S, Elston R. Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease. Neurology 1998;51:131-5.
  • 60
    • 0343907873 scopus 로고    scopus 로고
    • Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease
    • Csaszar A, Kalman J, Szalai C, Janka Z, Romics L. Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease. Neurosci Lett 1997;230:151-4.
    • (1997) Neurosci Lett , vol.230 , pp. 151-154
    • Csaszar, A.1    Kalman, J.2    Szalai, C.3    Janka, Z.4    Romics, L.5
  • 61
    • 0041321068 scopus 로고    scopus 로고
    • Baron M, Jiménez-Escrig A, Orensanz L, Simon J, Pérez-Tur J. Apolipoprotein E Pittsburgh variant is not associated with the risk of late-onset Alzheimer's disease in a Spanish population. Am J Med Genet B Neuropsychiatr Genet 2003;120B:121-4.
    • Baron M, Jiménez-Escrig A, Orensanz L, Simon J, Pérez-Tur J. Apolipoprotein E Pittsburgh variant is not associated with the risk of late-onset Alzheimer's disease in a Spanish population. Am J Med Genet B Neuropsychiatr Genet 2003;120B:121-4.
  • 62
    • 0034663179 scopus 로고    scopus 로고
    • Roles for lipoprotein lipase in Alzheimer's disease: An association study
    • Baum L, Wiebusch H, Pang CP. Roles for lipoprotein lipase in Alzheimer's disease: an association study. Microsc Res Tech 2000;50:291-6.
    • (2000) Microsc Res Tech , vol.50 , pp. 291-296
    • Baum, L.1    Wiebusch, H.2    Pang, C.P.3
  • 63
    • 0037047469 scopus 로고    scopus 로고
    • Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease
    • Martin-Rehrmann MD, Cho HS, Rebeck GW. Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease. Neurosci Lett 2002;328:109-12.
    • (2002) Neurosci Lett , vol.328 , pp. 109-112
    • Martin-Rehrmann, M.D.1    Cho, H.S.2    Rebeck, G.W.3
  • 64
    • 20844462230 scopus 로고    scopus 로고
    • Mitochondrial DNA variants in a portuguese population of patients with Alzheimer's disease
    • Grazina M, Silva F, Santana I, Pratas J, Santiago B, Oliveira M, et al. Mitochondrial DNA variants in a portuguese population of patients with Alzheimer's disease. Eur Neurol 2005;53:121-4.
    • (2005) Eur Neurol , vol.53 , pp. 121-124
    • Grazina, M.1    Silva, F.2    Santana, I.3    Pratas, J.4    Santiago, B.5    Oliveira, M.6
  • 65
    • 21344432980 scopus 로고    scopus 로고
    • Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients
    • Cai L, Tang G, Chen L, Zhang B, Jiang S, Ren D. Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients. Neuroreport 2005;16:1023-6.
    • (2005) Neuroreport , vol.16 , pp. 1023-1026
    • Cai, L.1    Tang, G.2    Chen, L.3    Zhang, B.4    Jiang, S.5    Ren, D.6
  • 66
    • 0034606268 scopus 로고    scopus 로고
    • Collins JS, Perry RT, Watson B, Jr., Harrell LE, Acton RT, Blacker D, et al. Association of a haplotype for tumor necrosis factor in siblings with late- onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet 2000;96:823-30.
    • Collins JS, Perry RT, Watson B, Jr., Harrell LE, Acton RT, Blacker D, et al. Association of a haplotype for tumor necrosis factor in siblings with late- onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet 2000;96:823-30.
  • 67
    • 2942741011 scopus 로고    scopus 로고
    • A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease
    • Licastro F, Veglia F, Chiappelli M, Grimaldi LM, Masliah E. A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease. Neurobiol Aging 2004;25:1017-22.
    • (2004) Neurobiol Aging , vol.25 , pp. 1017-1022
    • Licastro, F.1    Veglia, F.2    Chiappelli, M.3    Grimaldi, L.M.4    Masliah, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.