Functional Hydration and Conformational Gating of Proton Uptake in Cytochrome c Oxidase

Journal of Molecular Biology

Volumn 387, Issue 5, 2009, Pages 1165-1185

  Henry, Rowan M ^a,b   Yu, Ching Hsing ^a,b   Rodinger, Tomas ^a,b   Pomès, Régis ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

distributed replica sampling; free energy simulations; protein hydration; redox coupled proton pump; water mediated proton transport

Indexed keywords

ALANINE; ASPARAGINE; CYTOCHROME C OXIDASE; MUTANT PROTEIN; VALINE;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; HYDRATION; ISOMERIZATION; MOLECULAR MECHANICS; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; PHENOTYPE; PRIORITY JOURNAL; PROTON TRANSPORT; SIMULATION; WILD TYPE;

EID: 63449091255     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.02.042     Document Type: Article

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