An efficient access to 3,6-disubstituted 1H-pyrazolo[3,4-b]pyridines via a one-pot double SNAr reaction and pyrazole formation

Tetrahedron Letters

Volumn 50, Issue 20, 2009, Pages 2293-2297

  Zhong, Yong Li ^a   Lindale, Matthew G ^a   Yasuda, Nobuyoshi ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

2,6 difluoro 3 ketopyridines; Double SNAr reaction; Lithiation; One pot synthesis; Pyrazole formation

Indexed keywords

2 TERT BUTYLAMINO 2 FLUORO 3 BENZOTHIOPHENOYLPYRIDINE; 2,6 DIFLUORO 3 KETOPYRIDINE DERIVATIVE; 6 TERT BUTYLAMINO 2 FLUORO 3 BENZOTHIOPHENOYLPYRIDINE; HYDRAZINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD;

EID: 63349096176     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.02.142     Document Type: Article

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32. 3) δ 157.9, 152.8, 137.9, 137.7, 135.8, 135.4, 131.5, 128.7, 126.7, 122.2, 121.8, 117.5, 108.1, 105.7, 51.7, 29.2, 21.6.