Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6- yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 12, 1998, Pages 1551-1554

  Hirokawa, Yoshimi ^a   Yoshida, Naoyuki ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 METHYL 1H IMIDAZOL 4 YL) 1 (1 METHYL 1H INDOL 3 YL) 1 PROPANONE; DOPAMINE 2 RECEPTOR; NICOTINAMIDE DERIVATIVE; SEROTONIN 3 RECEPTOR; SPIPERONE;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; ISOMER; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; NIACINAMIDE; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032537577     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00258-3     Document Type: Article

References (9)

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4. 3); 9a: δ 2.98 (d, 3H, J = 6 Hz), 3.87 (s, 3H), 5.49 (br s, 1H), 6.24 (dd, 1H, J = 2.0, 8.5 Hz), 8.09 (dd, 1H, J = 8.5, 9.5 Hz). 10a: δ 3.03 (d, 3H, J = 5 Hz), 3.85 (s, 3H), 6.07 (dd, 1H, J = 3.0, 8.5 Hz), 8.12 (br, 1H), 8.18 (t, 1H, J = 8.5 Hz).
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