The role of BDNF and HPA axis in the neurobiology of burnout syndrome

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 6, 2008, Pages 1459-1465

  Onen Sertoz, Ozen ^a   Tolga Binbay, Ibrahim ^a   Koylu, Ersin ^a   Noyan, Aysin ^a   Yildirim, Emre ^a   Elbi Mete, Hayriye ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

Basal circulating cortisol; BDNF; Burnout; Depression; Dexamethasone suppression test

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DEXAMETHASONE; HYDROCORTISONE; PRASTERONE SULFATE;

ADULT; ANXIETY; ARTICLE; BURNOUT; CHRONIC STRESS; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DEPERSONALIZATION; DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; DISEASE ASSOCIATION; DRUG DOSE COMPARISON; EVENING DOSAGE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LOGISTIC REGRESSION ANALYSIS; MALE; MOOD; NEUROBIOLOGY; PSYCHIATRIC DIAGNOSIS; PSYCHOSOMATIC DISORDER; SYMPTOMATOLOGY;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; BURNOUT, PROFESSIONAL; CASE-CONTROL STUDIES; DEXAMETHASONE; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LOGISTIC MODELS; MALE; NURSES; PHYSICIANS; PITUITARY FUNCTION TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOLOGY; QUESTIONNAIRES;

EID: 47749126915     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.05.001     Document Type: Article

References (61)

1. Aydemir O., Deveci A., and Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry 29 (2005) 261-265
2. Beck A.T. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
3. Beck A.T., Epstein N., Brown G., and Steer R.A. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 56 (1988) 893-897
4. Corapci{dotless}oglu A., Aydemir O., Yi{dotless}ldi{dotless}z M., Danaci{dotless} A.E., and Koroglu E. Structured Clinical Interview for DSM-IV Axis I disorders [published in Turkish] (1999), Doctors Association Press, Ankara
5. Dag I. The reliability and validity of Symptom Check List-90 (SCL-90) for university students [article in Turkish]. Turk J Psychiatry 2 (1991) 5-12
6. de Kloet C., Van Pelt J., Manuel R., Heijnen C., and Westenberg H. Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology 33 (2008) 313-320
7. Derogatis L.R. SCL-90: Administration, Scoring and Procedure Manual-I for the Revised Version (1977), John Hopkins University School of Medicine, Clinical Psychometrics Unit, Baltimore, USA
8. Duman R.S., and Monteggia L.M.A. Neurotrophic model for stress-related mood disorders. Biol Psychiatry 59 (2006) 1116-1127
9. Duman R.S., Malberg J., Nakagawa S., and D'Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48 (2000) 732-739
10. Ehlert U., Gaab J., and Heinrichs M. Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis. Biol Psychol 57 (2001) 141-152
11. Embriaco N., Azoulay E., Barrau K., Kentish N., Pochard F., Loundou A., and Papazian L. High level of burnout in intensivists: prevalence and associated factors. Am J Resp Crit Care Med 175 (2007) 686-692
12. Ergin C. Turkish health personnel norms for Maslach Burnout Inventory [article in Turkish]. J Psychiatry Psychol Psychopharmacology 4 (1996) 28-33
13. Eriksson P.S., and Wallin L. Functional consequences of stress-related suppression of adult hippocampal neurogenesis - a novel hypothesis on the neurobiology of burnout. Acta Neurol Scand 110 (2004) 275-280
14. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (SCIDI), Clinician Version (1997), American Psychiatric Press Inc., Washington, DC
15. Fries E., Hesse J., Hellhammer J., and Hellhammer D.H. A new view on hypocortisolism. Psychoneuroendocrinology 30 (2005) 1010-1016
16. Gaab J., Sonderegger L., Scherrer S., and Ehlert U. Psychoneuroendocrine effects of cognitive-behavioral stress management in a naturalistic setting-a randomized controlled trial. Psychoneuroendocrinology 31 (2006) 428-438
17. Gonul A.S., Akdeniz F., Taneli F., Donat O., Eker C., and Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 255 (2005) 381-386
18. Gould E., Tanapat P., McEwen B.S., Flügge G., and Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 95 (1998) 3168-3171
19. Grossi G., Perski A., Ekstedt M., Johansson T., Lindström M., and Holm K. The morning salivary cortisol response in burnout. J Psychosom Res 59 (2005) 103-111
20. Guzman-Marin R., Ying Z., Suntsova N., Methippara M., Bashir T., Szymusiak R., et al. Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats. J Physiol 15 (2006) 807-819
21. Heim C., Ehlert U., and Hellhammer D.H. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25 (2000) 1-35
22. Hisli N. The validity and reliability of Beck Depression Inventory for university students. [article in Turkish] Turk J Psychol 7 (1989) 3-13
23. Huang E.J., and Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24 (2001) 677-736
24. Kempermann G., and Kronenberg G. Depressed new neurons-adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 54 (2003) 499-503
25. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., and Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109 (2002) 143-148
26. Kolassa I.T., Eckart C., Ruf M., Neuner F., de Quervain D.J., and Elbert T. Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) under going a diagnostic interview. BMC Psychiatry 4 7 (2007) 54
27. Kozlovsky N., Mader M.A., Kaplan Z., Katler M., Zohar J., and Cohen H. Long-term down-regulation of BDNF-nRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response. Int J Neuropsychopharmacol 10 (2007) 741-758
28. Kudielka B.M., Bellingrath S., and Hellhammer D.H. Cortisol in burnout and vital exhaustion: an overview. G Ital Med Lav Erg 28 (2006) 34-72
29. Langelaan S., Bakker A.B., Schaufeli W.B., Van Rhenen W., and Van Doornen L.J.P. Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?. Scand J Work Environ Health 32 (2006) 339-348
30. Laske C., Stransky E., Eschweiler G.W., Klein R., Wittorf A., Leyhe T., et al. Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants. J Psychiatr Res 41 (2007) 600-605
31. Maslach C., and Jackson S.E. Maslach Burnout Inventory Manual. 2nd ed. (1986), Consulting Psychologist Press, Palo Alto
32. Maslach C., Schaufeli W.B., and Leiter M.P. Job burnout. Annu Rev Psychol 52 (2001) 397-422
33. Melamed S., Ugarten U., Shirom A., Kahana L., Lerman Y., and Froom P. Chronic burnout, somatic arousal and elevated salivary cortisol levels. J Psychosom Res 46 (1999) 591-598
34. Maren S., and Hobin J.A. Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala. Learn Mem 14 (2007) 318-324
35. McEwen B. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci 8 (2006) 367-381
36. Mirescu C., and Gould E. Stress and adult neurogenesis. Hippocampus 16 (2006) 233-238
37. Mitoma M., Yoshimura R., Sugita A., Umene W., Hori H., Nakano H., et al. Stress at work alters serum derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxypheylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress?. Prog Neuro-Psychopharmacol Biol Psychiatry 32 (2007) 679-685
38. Moch S.L., Panz V.R., Joffe B.I., Havlik I., and Moch J.D. Longitudinal changes in pituitary-adrenal hormones in South African women with burnout. Endocrine 21 (2003) 267-272
39. Mommersteeg P.M.C., Heijnen C.J., Keijsers G.P.J., Verbraak M.J.P.M., and Van Doornen L.J.P. Cortisol deviations in people with burnout before and after psychotherapy: a pilot study. Health Psychol 25 (2006) 243-248
40. Mommersteeg P.M.C., Heijnen C.J., Verbraak M.J.P.M., and van Doornen L.J.P. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 31 (2006) 216-225
41. Morgan C.A., Cho T., Hazlett G., Coric V., and Morgan J. The impact of burnout on human physiology and on operational performance: a prospective study of soldiers enrolled in the combat diver qualification course. Yale J Biol Med 75 (2002) 199-205
42. Pruessner J.C., Hellhammer D.H., and Kirschbaum C. Burnout, perceived stress, and cortisol responses to awakening. Psychosom Med 61 (1999) 197-204
43. Raison C.L., and Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 160 (2003) 1554-1565
44. Sarchielli P., Mancini M.L., Floridi A., Coppola F., Rossi C., Nordi K., et al. Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome. J Pain 8 (2007) 737-745
45. Schmidt H.D., and Duman R.S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 18 (2007) 391-718
46. Shalev A.Y., Videlock E.J., Peleg T., Segmen R., Pitman R.K., and Yehuda R. Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part-I: HPA-axis responses. Int J Neuropsychopharmacol 11 (2008) 365-372
47. Sheline Y.I., Sanghavi M., Mintun M.A., and Gado M.H. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 19 (1999) 5034-5043
48. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54 (2003) 70-75
49. Song L., Che W., Min-wei W., Murakami Y., and Matsumoto K. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol. Biochem Behav 83 (2006) 186-193
50. Sonnentag S. Burnout and functioning of the hypothalamus-pituitary-axis-there are no simple answers. Scand J Work Environ Health 32 (2006) 333-337
51. Sonnenschein M., Mommersteeg P.M.C., Houtveen J.H., Sorbi M.J., Schaufeli W.B., and Van Doornen L.J.P. Exhaustion and endocrine functioning in clinical burnout: an in-depth study using the experience sampling method. Biol Psychol 75 (2007) 176-184
52. Söderström M., Ekstedt M., and Akerstedt T. Weekday and weekend patterns of diurnal cortisol, activation and fatigue among people scoring high for burnout. Scand J Work Environ Health 2 (2006) 35-40
53. Tanriverdi F., Karaca Z., Unluhizarci K., and Kelestimur F. The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome. Stress 10 (2007) 13-25
54. Tsankova N.M., Berton O., Renthal W., Kumar A., Neve R.L., and Nestler E.J. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9 (2006) 519-525
55. Ulusoy M., Şahin N., and Erkman H. Turkish version of the beck anxiety inventory: psychometric properties. J Cog Psychother 12 (1988) 28-35
56. Van Den Eede F., Moorkens G., Van Houdenhove B., Cosyns P., and Claes S.J. Hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome. Neuropsychobiology 55 (2007) 112-120 2007
57. Vaynman S., Ying Z., and Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20 (2004) 2580-2590
58. WHO. ICD-10; International Statistical Classification of Diseases and Related Health Problems (1994), World Health Organization, Geneva
59. Wingenfeld K., Wagner D., Schmidt I., Meinlschmidt G., Hellhammer D.H., and Heim C. The low dose dexamethasone suppression test in fibromyalgia. J Psychosom Res 62 (2007) 85-91
60. Yehuda R., Halligan S.L., Golier J.A., Grossman R., and Bierer L.M. Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology 29 (2004) 389-404
61. Yoshimura R., Mitoma M., Sugita A., Hori H., Okamoto T., Umene W., et al. Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 31 (2007) 1034-1037