Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics

Korean Journal of Internal Medicine

Volumn 23, Issue 4, 2008, Pages 176-181

  Choi, Inseon S ^a   Cui, Yong ^b   Koh, Young Ah ^b   Lee, Hyun Chul ^a   Cho, Yong Bum ^a   Won, Young Ho ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Asthma; Atopy; Dehydroepiandrosterone; Mononuclear cells, Th2

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 5; METHACHOLINE; PRASTERONE; CYTOKINE; IMMUNOLOGICAL ADJUVANT;

ADULT; AIRWAY DYNAMICS; ARTICLE; ASTHMA; ATOPY; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; SKIN MANIFESTATION; TH2 CELL; ADOLESCENT; CULTURE TECHNIQUE; DRUG EFFECT; METABOLISM; PATHOLOGY;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; ASTHMA; CELL CULTURE TECHNIQUES; CYTOKINES; DEHYDROEPIANDROSTERONE; HUMANS; MALE; TH2 CELLS; YOUNG ADULT;

EID: 63249118908     PISSN: 12263303     EISSN: 20056648     Source Type: Journal    
DOI: 10.3904/kjim.2008.23.4.176     Document Type: Article

References (28)

1. Ricci M, Rossi O, Bertoni M, Matucci A. The importance of Th2-like cells in the pathogenesis of airway allergic inflammation. Clin Exp Allergy 23:360-369, 1993
2. Herz U, Gerhold K, Gruber C, Braun A, Wahn U, Renz H, Paul K. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J Allergy Clin Immunol 102:867-874, 1998
3. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of T-helper Type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am J Respir Cell Mol Biol 22:176-182, 2000
4. Daynes RA, Dudley DJ, Araneo BA. Regulation of murine lymphokine production in vivo: II. dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur J Immunol 20:793-802, 1990
5. Araghi-Niknam M, Zhang Z, Jiang S, Call O, Eskelson CD, Watson RR. Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus. Proc Soc Exp Biol Med 216:386-391, 1997
6. Yu CK, Yang BC, Lei HY, Chen YC, Liu YH, Chen CC, Liu CW. Attenuation of house dust mite Dermatophagoides farinae-induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down-regulation of TH2 response. Clin Exp Allergy 29:414-422, 1999
7. Yu CK, Liu YH, Chen CL. Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. J Microbiol Immunol Infect 35:199-202, 2002
8. Verthelyi D, Klinman DM. Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 100:384-390, 2000
9. Feher KG, Koo E, Feher T. Adrenocortical function in bronchial asthma. Acta Med Hung 40:125-131, 1983
10. Dunn PJ, Mahood CB, Speed JF, Jury DR. Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N Z Med J 97:805-808, 1984
11. Tabata N, Tagami H, Terui T. Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis. Arch Dermatol Res 289:410-414, 1997
12. Choi IS, Lee S, Kim DH, Chung SW, Lee YC, Cho JY, Lee WJ. Airways are more reactive to histamine than to methacholine in patients with mild airway hyperresponsiveness, regardless of atopy. Korean J Intern Med 22:164-170, 2007
13. Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD. Relationships of bronchial responsiveness assessed by methacholine to serum IgE, lung function, symptoms, and diagnoses in 11-year-old New Zealand children. J Allergy Clin Immunol 90:376- 385, 1992
14. Sudo N, Yu XN, Kubo C. Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice. Immunol Lett 79:177-179, 2001
15. Fernandez-Botran R, Sanders VM, Mosmann TR, Vitetta ES. Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. J Exp Med 168:543-558, 1988
16. Yoshida M, Leigh R, Matsumoto K, Wattie J, Ellis R, O'Byrne, Inman MD. Effect of interferon-gamma on allergic airway responses in interferon-gamma- deficient mice. Am J Respir Crit Care Med 166:451-456, 2002
17. Huang TJ, MacAry PA, Eynott P, Moussavi A, Daniel KC, Askenase PW, Kemeny DM, Chung KF. Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol 166:207-217, 2001
18. Padgett DA, Loria RM. Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol. J Neuroimmunol 84:61-68, 1998
19. Araneo BA, Dowell T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells. Blood 78:688-699, 1991
20. Loria RM, Padgett DA. Control of the immune response by DHEA and its metabolites. Rinsho Byori 46:505-517, 1998
21. Hernandez-Pando R, De La Luz Streber M, Orozco H, Arriaga K, Pavon L, Al-Nakhli SA, Rook GA. The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice. Immunology 95:234-241, 1998
22. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737-742, 1997
23. Umetsu DT, Akbari O, DeKruyff RH. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol 112:480-487, 2003
24. Borish L, Rosenwasser LJ. Cytokines in allergic inflammation. In: Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simons FE, eds. Middleton's allergy principles & practice. 6th ed. p.135-157, Philadelphia, Mosby, 2003
25. Cheng GF, Tseng J. Regulation of murine interleukin-10 production by dehydroepiandrosterone. J Interferon Cytokine Res 20:471-478, 2000
26. Okabe T, Haji M, Takayanagi R, Adachi M, Imasaki K, Kurimoto F, Watanabe T, Nawata H. Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes. J Clin Endocrinol Metab 80:2993-2996, 1995
27. Bozza VV, D'Attilio L, Mahuad CV, Giri AA, del Rey A, Besedovsky H, Bottasso O, Bay ML. Altered cortisol/DHEA ratio in tuberculosis patients and its relationship with abnormalities in the mycobacterial-driven cytokine production by peripheral blood mononuclear cells. Scand J Immunol 66:97-103, 2007
28. Cui Y, Choi IS, Koh YA, Lin XH, Cho YB, Won YH. Effects of combined BCG and DHEA treatment in preventing the development of asthma. Immunol Invest 37:191-202, 2008