Effects of Baicalin on inflammatory mediators and pancreatic acinar cell apoptosis in rats with sever acute pancreatitis

Journal of Research in Medical Sciences

Volumn 14, Issue 1, 2009, Pages 19-27

  Zhang, Xiping ^a   Tian, Hua ^b   Chen, Hanqing ^c   Chen, Li ^b   Yu, Binya ^c   Ma, Jing ^c  

^a HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Baicalin; Inflammatory mediators; Octreotide; Severe acute pancreatitis; Tissue microarrays

Indexed keywords

BAICALIN; ENDOTOXIN; NITRIC OXIDE; OCTREOTIDE; PROTEIN BAX; PROTEIN BCL 2;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASCITES; BODY WEIGHT; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENDOTOXIN DETECTION; HISTOPATHOLOGY; MALE; MORTALITY; NONHUMAN; PROTEIN EXPRESSION; RAT; SURVIVAL RATE; TISSUE DISTRIBUTION;

EID: 63249116266     PISSN: 17351995     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Shi C, Andersson R, Zhao X, Wang X. Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction. Pancreatology 2005; 5(4-5):492-500.
2. Koussoulas V, Tzivras M, Karagianni V, Spyridaki E, Plachouras D, Giamarellou H, et al. Monocytes in systematic inflammatory response syndrome: differences between sepsis and acute pancreatitis. World J Gastroenterol 2006; 12(41):6711-4.
3. Abu-Zidan FM, Windsor JA. Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. Eur J Surg 2002; 168(4):215-9.
4. Yousaf M, McCallion K, Diamond T. Management of severe acute pancreatitis. Br J Surg 2003; 90(4):407-20.
5. Bai Y, Liu Y, Jia L, Jiang H, Ji M, Lv N et al. Severe acute pancreatitis in China: etiology and mortality in 1976 patients. Pancreas 2007; 35(3):232-7.
6. Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001; 7(3):167- 202.
7. Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis. Gastroenterology 1996; 110(2):639-42.
8. Exley AR, Leese T, Holliday MP, Swann RA, Cohen J. Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis. Gut 1992; 33(8):1126-8.
9. Vaccaro MI, Calvo EL, Suburo AM, Sordelli DO, Lanosa G, Iovanna JL. Lipopolysaccharide directly affects pancreatic acinar cells: implications on acute pancreatitis pathophysiology. Dig Dis Sci 2000; 45(5):915-26.
10. Wig JD, Kochhar R, Ray JD, Krishna Rao DV, Gupta NM, Ganguly NK. Endotoxemia predicts outcome in acute pancreatitis. J Clin Gastroenterol 1998; 26(2):121-4.
11. Wink DA, Mitchell JB. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic Biol Med 1998; 25(4-5):434-56.
12. Chen CC, Wang SS, Lee FY, Chang FY, Lee SD. Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 1999; 94(1):213-8.
13. Planas M, Perez A, Iglesia R, Porta I, Masclans JR, Bermejo B. Severe acute pancreatitis: treatment with somatostatin. Intensive Care Med 1998; 24(1):37-9.
14. Shor NA, Levina VP, Ioffe IV, Andreeva IV, Chumak I, Zhadanov VI, et al. Application of octreotide in patients with acute pancreatitis. Klin Khir 2004;(2):15-17.
15. Wenger FA, Kilian M, Heukamp I, Foitzik T, Jacobi CA, Guski H, et al. Effects of octreotide in acute hemorrhagic necrotizing pancreatitis in rats. J Gastroenterol Hepatol 2007; 22(11):1872-76.
16. Salem MZ, Cunha JE, Coelho AM, Sampietri SN, Machado MC, Penteado S, et al. Effects of octreotide pretreatment in experimental acute pancreatitis. Pancreatology 2003; 3(2):164-8.
17. Yeh DC, Wu CC, Liu TJ, P'eng FK. Management of acute pancreatitis: results of a 15-year experience in Taiwan. J Hepatobiliary Pancreat Surg 2001; 8(3):204-10.
18. Yuan Y, Gong Z, Lou K, Tu S, Di Z, Xu J. Effects and mechanisms of somatostatin analogs on apoptosis of pancreatic acinar cells in acute pancreatitis in mice. J Gastroenterol Hepatol 2001; 16(6):683-8.
19. Qiu Y, Li YY, Li SG, Song BG, Zhao GF. Effect of Qingyitang on activity of intracellular Ca2+-Mg2+-ATPase in rats with acute pancreatitis. World J Gastroenterol 2004; 10(1):100-4.
20. Woo KJ, Lim JH, Suh SI, Kwon YK, Shin SW, Kim SC, et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Immunobiology 2006; 211(5):359-68.
21. Wang GF, Wu ZF, Wan L, Wang QT, Chen FM. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. Pharmacology 2006; 77(2):71-7.
22. Zhao Y, Li H, Gao Z, Gong Y, Xu H. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on heminnitrite- H2O2 induced liver injury. Eur J Pharmacol 2006; 536(1-2):192-9.
23. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1999; 1472(3):643-50.
24. Zhang XP, Tian H, Cheng QH. The current situation in pharmacological study on baicalin. CHINESE PHARMACOLOGICAL BULLETIN 2003; 19(11):1212-15.
25. Liu IX, Durham DG, Richards RM. Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. J Pharm Pharmacol 2000; 52(3):361-6.
26. Zhang XP, Zhang L, He JX, Zhang RP, Cheng QH, Zhou YF, et al. Experimental study of therapeutic efficacy of Baicalin in rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(5):717-24.
27. Xiping Z, Jie Z, Qin X, Guanghua F, Yang C, Tongfa J, et al. Influence of Baicalin and Octerotide on NF-kappa B and P-selectin expression in liver and kidney of rats with severe acute pancreatitis. Inflammation 2009; 32(1): 1-11..
28. Zhang XP, Zhang J, Ren Z, Feng GH, Zhu W, Cai Y, et al. study on protecting effects of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis. World J Gastroenterol 2008; 14: 6551-9.
29. Zhang XP, Zhang L, Yang P, Zhang RP, Cheng QH. Protective effects of baicalin and octreotide on multiple organ injury in severe acute pancreatitis. Dig Dis Sci 2008; 53(2):581-91.
30. Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, et al. Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(38):5079-89.
31. Xiping Z, Hua T, Hanqing C, Li C, Zhiwei W, Keyi W, et al. The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP. Mediators Inflamm 2007; 2007:19469.
32. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, et al. Tissue microarrays for highthroughput molecular profiling of tumor specimens. Nat Med 1998; 4(7):844-7.
33. Zhang XP, Zhang L, He JX, Zhang RP, Cheng QH, Zhou YF, et al. Experimental study of therapeutic efficacy of Baicalin in rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(5):717-24.
34. Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML. Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and severity of acute pancreatitis. Am J Physiol 1996; 271(3 Pt 1):C982-C93.
35. Uhl W, Anghelacopoulos SE, Friess H, Buchler MW. The role of octreotide and somatostatin in acute and chronic pancreatitis. Digestion 1999; 60(2):23-31.
36. Saluja A, Hofbauer B, Yamaguchi Y, Yamanaka K, Steer M. Induction of apoptosis reduces the severity of caerulein-induced pancreatitis in mice. Biochem Biophys Res Commun 1996; 220(3):875-8.
37. Moch H, Kononen T, Kallioniemi OP, Sauter G. Tissue microarrays: what will they bring to molecular and anatomic pathology? Adv Anat Pathol 2001; 8(1):14-20.
38. Richter J, Wagner U, Kononen J, Fijan A, Bruderer J, Schmid U, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 2000; 157(3):787-94.