Genome-wide linkage scan for genes influencing plasma triglyceride levels in the veterans administration genetic epidemiology study

Diabetes

Volumn 58, Issue 1, 2009, Pages 279-284

  Coletta, Dawn K ^a   Schneider, Jennifer ^b   Hu, Shirley L ^a   Dyer, Thomas D ^b   Puppala, Sobha ^b   Farook, Vidya S ^b   Arya, Rector ^c   Lehman, Donna M ^c   Blangero, John ^b   Defronzo, Ralph A ^a,d   Duggirala, Ravindranath ^b   Jenkinson, Christopher P ^a,b,d  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR 2; TRIACYLGLYCEROL; MICROSATELLITE DNA;

ADULT; ARTICLE; BODY MASS; CHROMOSOME 12P; CONTROLLED STUDY; FAMILY; FEMALE; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENOTYPE; HEREDITY; HISPANIC; HUMAN; LINKAGE ANALYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CHROMOSOME 12; CHROMOSOME MAP; ETHNOLOGY; FAMILY HEALTH; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; METHODOLOGY; MIDDLE AGED; STATISTICS; UNITED STATES; VETERAN;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; DIABETES MELLITUS, TYPE 2; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LOD SCORE; MALE; MEXICAN AMERICANS; MICROSATELLITE REPEATS; MIDDLE AGED; PHENOTYPE; TEXAS; TRIGLYCERIDES; VETERANS;

EID: 63249094959     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0491     Document Type: Article

References (38)

1. Reaven GM: Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486, 1995
2. DeFronzo RA: Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis. Neth J Med 50:191-197, 1997
3. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP: A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 66:1237-1245, 2000
4. Richardson DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD, Almasy L, Blangero J, Stern MP, DeFronzo RA, Duggirala R, Jenkinson CP: Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans. Diabetologia 49:2317-2328, 2006
5. Bosse Y, Chagnon YC, Despres JP, Rice T, Rao DC, Bouchard C, Perusse L, Vohl MC: Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study. J Lipid Res 45:419-426, 2004
6. Elbein SC, Hasstedt SJ: Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q. Diabetes 51:528-535, 2002
7. Ng MC, So WY, Lam VK, Cockram CS, Bell GI, Cox NJ, Chan JC: Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes 53:2676-2683, 2004
8. Kullo IJ, Ding K, Boerwinkle E, Turner ST, de Andrade M: Quantitative trait loci influencing low density lipoprotein particle size in African Americans. J Lipid Res 47:1457-1462, 2006
9. Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C: Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet 12:137-144, 2003
10. Pollin TI, Hsueh WC, Steinle NI, Snitker S, Shuldiner AR, Mitchell BD: A genome-wide scan of serum lipid levels in the Old Order Amish. Atherosclerosis 173:89-96, 2004
11. Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen MR, Peltonen L: Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am J Hum Genet 64:1453-1463, 1999
12. Malhotra A, Elbein SC, Ng MC, Duggirala R, Arya R, Imperatore G, Adeyemo A, Pollin TI, Hsueh WC, Chan JC, Rotimi C, Hanson RL, Hasstedt SJ, Wolford JK: Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes 56:890-896, 2007
13. McPeek MS, Sun L: Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66:1076-1094, 2000
14. Sobel E, Lange K: Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 58:1323-1337, 1996
15. Sobel E, Papp JC, Lange K: Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet 70:496-508, 2002
16. Dyke B: PEDSYS: A Pedigree Data Management System. Population Genetics Laboratory, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, 1996 [Tech. rep. no. 2]
17. Heath SC: Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet 61:748-760, 1997
18. Heath SC, Snow GL, Thompson EA, Tseng C, Wijsman EM: MCMC segregation and linkage analysis. Genet Epidemiol 14:1011-1015, 1997
19. Amos CI: Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543, 1994
20. Blangero J, Almasy L: Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 14:959-964, 1997
21. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211, 1998
22. Self SG, Liang K-Y: Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605-610, 1987
23. Comuzzie AG, Williams JT: Correcting for ascertainment bias in the COGA data set. Genet Epidemiol 17:109-114, 1999
24. Duggirala R, Almasy L, Blangero J, Jenkinson CP, Arya R, DeFronzo RA, Stern MP, O'Connell P, the American Diabetes Association GENNID Study Group: Further evidence for type 2 diabetes susceptibility locus on chromosome 11q. Genet Epidemiol 24:240-242, 2003
25. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP: Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64:1127-1140, 1999
26. Puppala S, Dodd GD, Fowler S, Arya R, Schneider J, Farook VS, Granato R, Dyer TD, Almasy L, Jenkinson CP, Diehl AK, Stern MP, Blangero J, Duggirala R: A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans. Am J Hum Genet 78:377-392, 2006
27. Hunt KJ, Lehman DM, Arya R, Fowler S, Leach RJ, Goring HH, Almasy L, Blangero J, Dyer TD, Duggirala R, Stern MP: Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study. Diabetes 54:2655-2662, 2005
28. Lin JP: Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes. BMC Genet 31: S47, 2003
29. Suarez BK, Hampe CL, Van Eerdewegh P: Problems of replicating linkage claims in psychiatry. In Genetic Approaches to Mental Disorders. 1st ed. Gershon ES, Cloninger CR, Eds. American Psychiatric, Washington, DC, 1994, p. 23-46
30. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes of BioMedical Research; Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Ra°stam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336, 2007
31. Kathiresan S, Manning AK, Demissie S, D'Agostino RB, Surti A, Guiducci C, Gianniny L, Burtt NP, Melander O, Orho-Melander M, Arnett DK, Peloso GM, Ordovas JM, Cupples LA: A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet 8: S17, 2007
32. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40:161-169, 2008
33. Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, Wahlstrand B, Hedner T, Corella D, Tai ES, Ordovas JM, Berglund G, Vartiainen E, Jousilahti P, Hedblad B, Taskinen MR, Newton-Cheh C, Salomaa V, Peltonen L, Groop L, Altshuler DM, Orho-Melander M: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40:189-197, 2008
34. Berg AH, Combs TP, Scherer PE: ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13:84-89, 2002
35. Broedl UC, Lehrke M, Fleischer-Brielmaier E, Tietz AB, Nagel JM, Goke B, Lohse P, Parhofer KG: Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/ VLDL levels in patients with metabolic syndrome. Cardiovasc Diabetol 15:5-11, 2006
36. Vaxillaire M, Dechaume A, Vasseur-Delannoy V, Lahmidi S, Vatin V, Lepretre F, Boutin P, Hercberg S, Charpentier G, Dina C, Froguel P: Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes 55:856 - 861, 2006
37. Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR: Genetic variation in adiponectin receptor 1 and adi - ponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes 54:2245-2250, 2005
38. Kanazawa A, Tsukada S, Sekine A, Tsunoda T, Takahashi A, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S: Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Am J Hum Genet 75:832-843, 2004