Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte

Advances in Experimental Medicine and Biology

Volumn 643, Issue , 2009, Pages 523-532

  Ito, Takashi ^a   Fujio, Yasushi ^b   Schaffer, Stephen W ^b   Azuma, Junichi ^b  

^a OSAKA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOTOXIN; DOXORUBICIN; LUCIFERASE; PROTEASOME INHIBITOR; TAURINE; TAURINE TRANSPORTER; TONICITY RESPONSE ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; MEMBRANE PROTEIN; NFAT5 PROTEIN, RAT;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HEART MUSCLE CELL; ISOLATION PROCEDURE; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEART; HEART MUSCLE; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; PROMOTER REGION; WESTERN BLOTTING; WISTAR KYOTO RAT;

RATTUS;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DOXORUBICIN; GENE EXPRESSION REGULATION; HEART; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MYOCARDIUM; PROMOTER REGIONS, GENETIC; RATS; RATS, INBRED WKY; TAURINE; TRANSCRIPTION FACTORS;

EID: 63149192309     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-75681-3_54     Document Type: Conference Paper

References (39)

1. Arai M, Tomaru K, Takizawa T, Sekiguchi K, Yokoyama T, Suzuki T, Nagai R (1998) Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits. J Mol Cell Cardiol 30:243-254
2. Chapman RA, Suleiman MS, Earm YE (1993) Taurine and the heart. Cardiovasc Res 27:358-363
3. Chesney RW (1985) Taurine:its biological role and clinical implications. Adv Pediatr 32:1-42
4. Hamaguchi T, Azuma J, Harada H, Takahashi K, Kishimoto S, Schaffer SW (1989) Protective effect of taurine against doxorubicin-induced cardiotoxicity in perfused chick hearts. Pharmacol Res 21:729-734
5. Han X, Chesney RW (2003) Regulation of taurine transporter gene (TauT) by WT1. FEBS Lett 540:71-76
6. Han X, Patters AB, Chesney RW (2002) Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. J Biol Chem 277:39266-39273
7. Harada H, Cusack BJ, Olson RD, Stroo W, Azuma J, Hamaguchi T, Schaffer SW (1990) Taurine deficiency and doxorubicin:interaction with the cardiac sarcolemmal calcium pump. Biochem Pharmacol 39:745-751
8. Heller-Stilb B, van Roeyen C, Rascher K, Hartwig HG, Huth A, Seeliger MW, Warskulat U, Haussinger D (2002) Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. Faseb J 16:231-233
9. Ho SN (2003) The role of NFAT5/TonEBP in establishing an optimal intracellular environment. Arch Biochem Biophys 413:151-157
10. Huxtable R, Bressler R (1974) Taurine concentrations in congestive heart failure. Science 184:1187-1188
11. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101-163
12. Ito H, Miller SC, Billingham ME, Akimoto H, Torti SV, Wade R, Gahlmann R, Lyons G, Kedes L, Torti FM (1990) Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro. Proc Natl Acad Sci USA 87:4275-4279
13. Ito T, Fujio Y, Hirata M, Takatani T, Matsuda T, Muraoka S, Takahashi K, Azuma J (2004) Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells. Biochem J 382:177-182
14. Ito T, Fujio Y, Takahashi K, Azuma J (2007) Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J Biol Chem 282:1152-1160
15. Ko BC, Turck CW, Lee KW, Yang Y, Chung SS (2000) Purification, identification, and characterization of an osmotic response element binding protein. Biochem Biophys Res Commun 270:52-61
16. Kumarapeli AR, Horak KM, Glasford JW, Li J, Chen Q, Liu J, Zheng H, Wang X (2005) A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. Faseb J 19:2051-2053
17. Lopez-Rodriguez C, Antos CL, Shelton JM, Richardson JA, Lin F, Novobrantseva TI, Bronson RT, Igarashi P, Rao A, Olson EN (2004) Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci USA 101:2392-2397
18. Maouyo D, Kim JY, Lee SD, Wu Y, Woo SK, Kwon HM (2002) Mouse TonEBP-NFAT5:expression in early development and alternative splicing. Am J Physiol Renal Physiol 282:F802-F809
19. Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines:molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229
20. Miyakawa H, Woo SK, Chen CP, Dahl SC, Handler JS, Kwon HM (1998) Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity. Am J Physiol 274:F753-F761
21. Moise NS, Pacioretty LM, Kallfelz FA, Stipanuk MH, King JM, Gilmour RF, Jr. (1991) Dietary taurine deficiency and dilated cardiomyopathy in the fox. Am Heart J 121:541-547
22. Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH (2004) Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109:1877-1885
23. Pion PD, Kittleson MD, Rogers QR, Morris JG (1987) Myocardial failure in cats associated with low plasma taurine:a reversible cardiomyopathy. Science 237:764-768
24. Poizat C, Sartorelli V, Chung G, Kloner RA, Kedes L (2000) Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol 20:8643-8654
25. Rim JS, Atta MG, Dahl SC, Berry GT, Handler JS, Kwon HM (1998) Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region. J Biol Chem 273:20615-20621
26. Satoh H, Sperelakis N (1998) Review of some actions of taurine on ion channels of cardiac muscle cells and others. Gen Pharmacol 30:451-463
27. Schaffer SW, Azuma J, Takahashi K, Mozaffari M (2003) Why is taurine cytoprotective? Adv Exp Med Biol 526:307-321
28. Schaffer SW, Solodushko V, Azuma J (2000a) Taurine-deficient cardiomyopathy:role of phospholipids, calcium and osmotic stress. Adv Exp Med Biol 483:57-69
29. Schaffer SW, Takahashi K, Azuma J (2000b) Role of osmoregulation in the actions of taurine. Amino Acids 19:527-546
30. Singal PK, Iliskovic N (1998) Doxorubicin-induced cardiomyopathy. N Engl J Med 339:900-905
31. Takahashi K, Ohyabu Y, Solodushko V, Takatani T, Itoh T, Schaffer SW,Azuma J (2003) Taurine renders the cell resistant to ischemia-induced injury in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol 41:726-733
32. Takatani T, Takahashi K, Uozumi Y, Matsuda T, Ito T, Schaffer SW, Fujio Y, Azuma J (2004) Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochem Biophys Res Commun 316:484-489
33. Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N (1986) Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am Heart J 112:1278-1284
34. Trama J, Go WY, Ho SN (2002) The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol 169:5477-5488
35. Trama J, Lu Q, Hawley RG, Ho SN (2000) The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner. J Immunol 165:4884-4894
36. Uchida S, Kwon HM, Yamauchi A, Preston AS, Marumo F, Handler JS (1992) Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci USA 89:8230-8234
37. Uozumi Y, Ito T, Hoshino Y, Mohri T, Maeda M, Takahashi K, Fujio Y, Azuma J (2006) Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles. Biochem J 394:699-706
38. Wang Y, Ko BC, Yang JY, Lam TT, Jiang Z, Zhang J, Chung SK, Chung SS (2005) Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks. J Biol Chem 280:19986-19991
39. Woo SK, Lee SD, Kwon HM (2002) TonEBP transcriptional activator in the cellular response to increased osmolality. Pflugers Arch 444:579-585