Syntheses of novel high affinity ligands for opioid receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2289-2294

  Wentland, Mark P ^a   Lou, Rongliang ^a   Lu, Qun ^a   Bu, Yigong ^a   Denhardt, Christoph ^a   Jin, Jin ^a   Ganorkar, Rakesh ^a   VanAlstine, Melissa A ^a   Guo, Chengyun ^b   Cohen, Dana J ^c   Bidlack, Jean M ^c  

^a Research Rensselaer Polytechnic Institute   (United States)

^b ALKERMES INC   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Bioactive conformation; GPCRs; Opioid ligands

Indexed keywords

17 METHYLNALTREXONE IODIDE; 6 DESOXONALTREXONE; AMIDE; DELTA OPIATE RECEPTOR; FURAN; HYDROMORPHONE; HYDROXYL GROUP; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALBUPHINE; NALTREXONE DERIVATIVE; NALTRINDOLE; OPIATE RECEPTOR; OPIATE RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; LIGAND BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR AFFINITY;

ANALGESICS, OPIOID; CRYSTALLOGRAPHY, X-RAY; FURANS; HUMANS; LIGANDS; NALTREXONE; NARCOTIC ANTAGONISTS; PROTEIN BINDING; RECEPTORS, OPIOID;

EID: 63149173765     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.078     Document Type: Article

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