Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids

International Journal of Biological Sciences

Volumn 5, Issue 3, 2009, Pages 215-225

  Lee, Sung Eun ^a,b,c   Li, Qing X ^a   Yu, Jian ^b  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c Nanotoxtech Inc   (South Korea)

Author keywords

Biopolymer; LC MS; MS; Organic acids; Proteomics; Ralstonia eutropha

Indexed keywords

ACETATE KINASE; ACETIC ACID; ACETOACETYL COENZYME A REDUCTASE; ACETYL COENZYME A; ACETYL COENZYME A ACYLTRANSFERASE; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A SYNTHASE; ARGININE; BACTERIAL ENZYME; CYSTEINE; ENOYL COENZYME A HYDRATASE; GLUCOSE; HISTIDINE; HISTIDINOL DEHYDROGENASE; LEVULINIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; METHIONINE; METHYLMALONYL COENZYME A MUTASE; OXIDOREDUCTASE; PHENYLALANINE; POLYALKANOATE SYNTHASE; POLYHYDROXYALKANOIC ACID; PROLINE; PROPIONIC ACID; PROPIONYL COENZYME A; PROPIONYL COENZYME A CARBOXYLASE; SERINE; SYNTHETASE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; ACETOACETYL-COA REDUCTASE; ALCOHOL DEHYDROGENASE; BACTERIAL PROTEIN; CARBOXYLIC ACID; FATTY ACID; PROPIONIC ACID DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ARTICLE; BACTERIUM CULTURE; CELL GROWTH; CONTROLLED STUDY; CUPRIAVIDUS NECATOR; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; LIQUID CHROMATOGRAPHY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS; TANDEM MASS SPECTROMETRY; UNINDEXED SEQUENCE; UPREGULATION; BIOSYNTHESIS; ENERGY METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN DATABASE;

BACTERIA (MICROORGANISMS); CUPRIAVIDUS NECATOR;

ACETIC ACID; ALCOHOL OXIDOREDUCTASES; BACTERIAL PROTEINS; CARBOXYLIC ACIDS; CUPRIAVIDUS NECATOR; DATABASES, PROTEIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENERGY METABOLISM; FATTY ACIDS; LEVULINIC ACIDS; OXIDATION-REDUCTION; POLYHYDROXYALKANOATES; PROPIONIC ACIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 63049102070     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5.215     Document Type: Article

References (23)

1. Reinecke F and Steinbuchel A. Ralstonia eutropha strain H16 as model organism for PHA metabolism and for biotechnological production of technically interesting biopolymers. J Mol Microbiol Biotechnol 2009; 16: 91-108.
2. Sudesh K., Abe H., and Doi Y. Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog Polym Sci 2000; 25: 1503-1555. (Pubitemid 32029920)
3. Rubin E.M. Genomics of cellulosic biofuels. Nature 2008; 454: 841-845.
4. Somleva M.N., Snell K.D., Beaulieu J.J., Peoples O.P., Garrison B.R., and Patterson N.A. Production of polyhydroxybutyrate in switchgrass, a value-added co-product in an important lignocellulosic biomass crop. Plant Biotechnol J 2008; 6: 663-678.
5. Grohmann K and Bothast R.J. Saccharification of corn fiber by combined treatment with dilute sulphuric acid and enzymes. Proc Biochem 1997; 32: 405-415. (Pubitemid 27197581)
6. Yu J., Zhang J., He J., Liu Z., and Yu Z. Combinations of mild physical or chemical pretreatment with biological pretreatment for enzymatic hydrolysis of rice hull. Bioresour Technol 2009; 100: 903-908.
7. Torget R., Walter P.J., Himmel M.E., and Grohmann K. Dilute-acid pretreatment of. corn residues and short-rotation woody crops. Appl Biochem Biotechnol 1991; 28: 75-86.
8. Larsson S., Palmqvist E., Hahn-Hagerdal B., et al. The generation of fermentation inhibitors during dilute acid hydrolysis of softwood. Enz Microb Technol 1999; 24: 151-159. (Pubitemid 29056189)
9. Yu J and Wang J. Metabolic flux modeling of detoxification of acetic acid by Ralstonia eutropha at slightly alkaline pH levels. Biotech Bioeng 2001; 73: 458-464. (Pubitemid 32574321)
10. Yu J and Stahl H. Microbial utilization and biopolyester synthesis of bagasse hydrolysates. Bioresour Technol 2008; 99: 8042-8048.
11. Yu J and Si Y. Metabolic carbon fluxes and biosynthesis of polyhydroxyalkanoates by Ralstonia eutropha on short chain fatty acids. Biotechnol Prog 2004; 20: 1015-1024. (Pubitemid 39059613)
12. Du G., Si Y., and Yu J. Inhibition by medium-chain-length fatty acids of formation of polyhydroxyalkanoates from volatile fatty acids by Ralstonia eutropha. Biotechnol Lett 2001; 23: 1613-1617. (Pubitemid 32970393)
13. Gorenflo V., Schmack G., and Vogel R. Steinbuchel, A., Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate- containing polyesters and characterization of their physical and mechanical properties. Biomacromolecules 2001; 2: 45-57. (Pubitemid 32707473)
14. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
15. Lee S.E., Seo J.S., Keum Y.S., Lee K.J., and Li Q.X. Fluoranthene metabolism and associated proteins in Mycobacterium sp. JS14. Proteomics 2007; 7: 2059-2069.
16. Berndt P., Hobohm U., and Largen H. Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints. Eletrophoresis 1999; 20: 3521-3526. (Pubitemid 30007249)
17. Buckel W. Anaerobic energy metabolism. In: Chlegel HG, ed. Biology of the Procaryotes. Germany: Thieme, Stuttgart. 1999: 278-326.
18. Horswill A.R and Escalante-Semerena J.C. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. J Bacteriol 1997; 179: 928-940.
19. Horswill A.R and Escalante-Semerena J.C. The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase. Microbiology 1999; 145: 1381-1388.
20. Horswill A.R and Escalante-Semerena J.C. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. J Bacteriol 1999; 181: 5615-5623.
21. Starai V.J., Takahashi H., Boeke J.D., and Escalante-Semerena J.C. Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 2003; 163: 545-555. (Pubitemid 36314538)
22. Lehmann C., Doseeva V., Pullalarevu S., et al. YbdK is a carboxylate-amine ligase with a gamma-glutamyl:Cysteine ligase activity: crystal structure and enzymatic assays. Proteins 2004; 56: 376-383. (Pubitemid 38850170)
23. Lee S.E., Li Q.X., and Yu J. Proteomic responses to formic acid on Ralstonia eutropha. Proteomics 2006; 6: 4259-4268.