Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses

Gastrointestinal Endoscopy

Volumn 69, Issue 4, 2009, Pages 786-799

  Barkun, Alan N ^a   Martel, Myriam ^a   Toubouti, Youssef ^a   Rahme, Elham ^a   Bardou, Marc ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALCOHOL; ANTACID AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; OCTREOTIDE; PLACEBO; POLIDOCANOL; PROTON PUMP INHIBITOR; THROMBIN;

ARGON PLASMA COAGULATION; ARTICLE; CLINICAL TRIAL; CLIP; DRUG EFFICACY; DRUG MEGADOSE; ELECTROCOAGULATION; EMBASE; ENDOSCOPIC THERAPY; HEMOSTASIS; HIGH RISK PATIENT; HUMAN; INTERMETHOD COMPARISON; MEDLINE; META ANALYSIS; MICROWAVE THERAPY; MORTALITY; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SYSTEMATIC REVIEW; THERMOCOAGULATION; TREATMENT OUTCOME;

HEMOSTASIS, ENDOSCOPIC; HUMANS; PEPTIC ULCER HEMORRHAGE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS;

EID: 62949245938     PISSN: 00165107     EISSN: 10976779     Source Type: Journal    
DOI: 10.1016/j.gie.2008.05.031     Document Type: Article

References (85)

1. Sacks H.S., Chalmers T.C., Blum A.L., et al. Endoscopic hemostasis. An effective therapy for bleeding peptic ulcers. JAMA 264 (1990) 494-499
2. Cook D.J., Guyatt G.H., Salena B.J., et al. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Gastroenterology 102 (1992) 139-148
3. Calvet X., Vergara M., Brullet E., et al. Addition of a second endoscopic treatment following epinephrine injection improves outcome in high-risk bleeding ulcers. Gastroenterology 126 (2004) 441-450
4. Barkun A., Bardou M., and Marshall J.K. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 139 (2003) 843-857
5. Bensoussan K., Fallone C.A., Barkun A.N., et al. A sampling of Canadian practice in managing nonvariceal upper gastrointestinal bleeding before recent guideline publication: is there room for improvement?. Can J Gastroenterol 19 (2005) 487-495
6. Kahi C.J., Jensen D.M., Sung J.J., et al. Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis. Gastroenterology 129 (2005) 855-862
7. Bai Y., and Li Z. Results of meta-analysis should be interpreted with caution. Am J Gastroenterol 103 (2007) 1826
8. Calvet X., Vergara M., Gisbert J., et al. Dual versus endoscopic monotherapy in bleeding peptic ulcers. Am J Gastroenterol 103 (2007) 1286-1287
9. Dickersin K., Scherer R., and Lefebvre C. Identifying relevant studies for systematic reviews. BMJ 309 (1994) 1286-1291
10. Forrest J.A., Finlayson N.D., and Shearman D.J. Endoscopy in gastrointestinal bleeding. Lancet II (1974) 394-397
11. Laine L., and Peterson W.L. Bleeding peptic ulcer. N Engl J Med 331 (1994) 717-727
12. Lo C.C., Hsu P.I., Lo G.H., et al. Comparison of hemostatic efficacy for epinephrine injection alone and injection combined with hemoclip therapy in treating high-risk bleeding ulcers. Gastrointest Endosc 63 (2006) 767-773
13. Leontiadis G.I., Sharma V.K., and Howden C.W. Proton pump inhibitor treatment for acute peptic ulcer bleeding. Cochrane Database Syst Rev (2006) CD002094
14. Bardou M., Toubouti Y., Benhaberou-Brun D., et al. Meta-analysis: proton-pump inhibition in high-risk patients with acute peptic ulcer bleeding. Aliment Pharmacol Ther 21 (2005) 677-686
15. Rockall T.A., Logan R.F., Devlin H.B., et al. Selection of patients for early discharge or outpatient care after acute upper gastrointestinal haemorrhage. National Audit of Acute Upper Gastrointestinal Haemorrhage. Lancet 347 (1996) 1138-1140
16. Laird N.M., and Ware J.H. Random-effects models for longitudinal data. Biometrics 38 (1982) 963-974
17. Brown H.K., and Kempton R.A. The application of REML in clinical trials. Stat Med 13 (1994) 1601-1617
18. DerSimonian R., and Laird N. Meta-analysis in clinical trials. Control Clin Trials 7 (1986) 177-188
19. Laupacis A., Sackett D.L., and Roberts R.S. An assessment of clinically useful measures of the consequences of treatment. N Engl J Med 318 (1988) 1728-1733
20. Higgins J.P., and Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 21 (2002) 1539-1558
21. Williams J.G., Higgins J.P., and Brayne C.E. Systematic review of prevalence studies of autism spectrum disorders. Arch Dis Child 91 (2006) 8-15
22. Macaskill P., Walter S.D., and Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med 20 (2001) 641-654
23. Moher D., Cook D.J., Eastwood S., et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. QUOROM Group. Br J Surg 87 (2000) 1448-1454
24. Sung J.J., Chan F.K., Lau J.Y., et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Ann Intern Med 139 (2003) 237-243
25. Bleau B.L., Gostout C.J., Sherman K.E., et al. Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointest Endosc 56 (2002) 1-6
26. Lin H.J., Tseng G.Y., Perng C.L., et al. Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding. Gut 44 (1999) 715-719
27. Soon M.S., Wu S.S., Chen Y.Y., et al. Monopolar coagulation versus conventional endoscopic treatment for high-risk peptic ulcer bleeding: a prospective, randomized study. Gastrointest Endosc 58 (2003) 323-329
28. Acalovschi I., Pascu O., and Draghici A. Nonsurgical control of upper gastrointestinal hemorrhage in old age patients: intragastric norepinephrine and endoscopic alcoholization of lesions. Intensive Care Med 16 (1990) 180-183
29. Bour B., Pariente E.A., Hamelin B., et al. Orally administered omeprazole versus injection therapy in the prevention of rebleeding from peptic ulcer with visible vessel. A multicenter randomized study. Gastroenterol Clin Biol 17 (1993) 329-333
30. Chua R.T., Lin H.J., Wang K., et al. Intravenous omeprazole prevents rebleeding in peptic ulcer patients with a non-bleeding visible vessel: a preliminary report of a randomized controlled study. Chung Hua I Hsueh Tsa Chih (Taipei) 57 (1996) 139-145
31. Gralnek I.M., Jensen D.M., Gornbein J., et al. Clinical and economic outcomes of individuals with severe peptic ulcer hemorrhage and nonbleeding visible vessel: an analysis of two prospective clinical trials. Am J Gastroenterol 93 (1998) 2047-2056
32. Grosso C., Rossi A., Gambitta P., et al. Non-bleeding visible vessel treatment: perendoscopic injection therapy versus omeprazole infusion. Scand J Gastroenterol 30 (1995) 872-875
33. Jaramillo J.L., Carmona C., Galvez C., et al. Efficacy of the heater probe in peptic ulcer with a non-bleeding visible vessel. A controlled, randomised study. Gut 34 (1993) 1502-1506
34. Jensen D.M., Kovacs T.O., Jutabha R., et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology 123 (2002) 407-413
35. Jung H.K., Son H.Y., Jung S.A., et al. Comparison of oral omeprazole and endoscopic ethanol injection therapy for prevention of recurrent bleeding from peptic ulcers with nonbleeding visible vessels or fresh adherent clots. Am J Gastroenterol 97 (2002) 1736-1740
36. Lin H.J., Wang K., Perng C.L., et al. Heater probe thermocoagulation and multipolar electrocoagulation for arrest of peptic ulcer bleeding. A prospective, randomized comparative trial. J Clin Gastroenterol 21 (1995) 99-102
37. Matthewson K., Swain C.P., Bland M., et al. Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers. Gastroenterology 98 (1990) 1239-1244
38. Moreto M., Zaballa M., Suarez M.J., et al. Endoscopic local injection of ethanolamine oleate and thrombin as an effective treatment for bleeding duodenal ulcer: a controlled trial. Gut 33 (1992) 456-459
39. Oxner R.B., Simmonds N.J., Gertner D.J., et al. Controlled trial of endoscopic injection treatment for bleeding from peptic ulcers with visible vessels. Lancet 339 (1992) 966-968
40. Rajgopal C., and Palmer K.R. Endoscopic injection sclerosis: effective treatment for bleeding peptic ulcer. Gut 32 (1991) 727-729
41. Rutgeerts P., Gevers A.M., Hiele M., et al. Endoscopic injection therapy to prevent rebleeding from peptic ulcers with a protruding vessel: a controlled comparative trial. Gut 34 (1993) 348-350
42. Tekant Y., Goh P., Alexander D.J., et al. Combination therapy using adrenaline and heater probe to reduce rebleeding in patients with peptic ulcer haemorrhage: a prospective randomized trial. Br J Surg 82 (1995) 223-226
43. Chou Y.C., Hsu P.I., Lai K.H., et al. A prospective, randomized trial of endoscopic hemoclip placement and distilled water injection for treatment of high-risk bleeding ulcers. Gastrointest Endosc 57 (2003) 324-328
44. Choudari C.P., Rajgopal C., and Palmer K.R. Comparison of endoscopic injection therapy versus the heater probe in major peptic ulcer haemorrhage. Gut 33 (1992) 1159-1161
45. Chung S.C., Leung J.W., Sung J.Y., et al. Injection or heat probe for bleeding ulcer. Gastroenterology 100 (1991) 33-37
46. Chung S.S., Lau J.Y., Sung J.J., et al. Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers. BMJ 314 (1997) 1307-1311
47. Chung I.K., Ham J.S., Kim H.S., et al. Comparison of the hemostatic efficacy of the endoscopic hemoclip method with hypertonic saline-epinephrine injection and a combination of the two for the management of bleeding peptic ulcers. Gastrointest Endosc 49 (1999) 13-18
48. Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers. A prospective, randomized trial. Gastroenterology 99 (1990) 1303-1306
49. Laine L., and Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: is local tamponade enough?. Gastrointest Endosc 55 (2002) 6-10
50. Lin H.J., Lee F.Y., Kang W.M., et al. Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage: a prospective, randomised controlled trial. Gut 31 (1990) 753-757
51. Ljubicic N. Efficacy of endoscopic clipping and long-term follow-up of bleeding Dieulafoy's lesions in the upper gastrointestinal tract. Hepatogastroenterology 53 (2006) 224-227
52. Llach J., Bordas J.M., Salmeron J.M., et al. A prospective randomized trial of heater probe thermocoagulation versus injection therapy in peptic ulcer hemorrhage. Gastrointest Endosc 43 (1996) 117-120
53. Panes J., Viver J., and Forne M. Randomized comparison of endoscopic microwave coagulation and endoscopic sclerosis in the treatment of bleeding peptic ulcers. Gastrointest Endosc 37 (1991) 611-616
54. Shimoda R., Iwakiri R., Sakata H., et al. Evaluation of endoscopic hemostasis with metallic hemoclips for bleeding gastric ulcer: comparison with endoscopic injection of absolute ethanol in a prospective, randomized study. Am J Gastroenterol 98 (2003) 2198-2202
55. Skok P., Krizman I., and Skok M. Argon plasma coagulation versus injection sclerotherapy in peptic ulcer hemorrhage: a prospective, controlled study. Hepatogastroenterology 51 (2004) 165-170
56. Sofia C., Portela F., Gregorio C., et al. Endoscopic injection therapy vs. multipolar electrocoagulation vs. laser vs. injection + octreotide vs. injection + omeprazole in the treatment of bleeding peptic ulcers. A prospective randomized study. Hepatogastroenterology 47 (2000) 1332-1336
57. Waring J.P., Sanowski R.A., Sawyer R.L., et al. A randomized comparison of multipolar electrocoagulation and injection sclerosis for the treatment of bleeding peptic ulcer. Gastrointest Endosc 37 (1991) 295-298
58. Ljubicic N., Supanc V., and Vrsalovic M. Efficacy of endoscopic clipping for actively bleeding peptic ulcer: comparison with polidocanol injection therapy. Hepatogastroenterology 51 (2004) 408-412
59. Rajgopal C., Amin J., and Palmer K.R. Combination adrenaline and ethanolamine endoscopic injection therapy does not impair peptic ulcer healing. J R Coll Surg Edinb 38 (1993) 335-336
60. Balanzo J., Villanueva C., Sainz S., et al. Injection therapy of bleeding peptic ulcer. A prospective, randomized trial using epinephrine and thrombin. Endoscopy 22 (1990) 157-159
61. Choudari C.P., and Palmer K.R. Endoscopic injection therapy for bleeding peptic ulcer; a comparison of adrenaline alone with adrenaline plus ethanolamine oleate. Gut 35 (1994) 608-610
62. Chung S.C., Leung J.W., Leong H.T., et al. Adding a sclerosant to endoscopic epinephrine injection in actively bleeding ulcers: a randomized trial. Gastrointest Endosc 39 (1993) 611-615
63. Chung S.C., Leong H.T., Chan A.C., et al. Epinephrine or epinephrine plus alcohol for injection of bleeding ulcers: a prospective randomized trial. Gastrointest Endosc 43 (1996) 591-595
64. Kubba A.K., Murphy W., and Palmer K.R. Endoscopic injection for bleeding peptic ulcer: a comparison of adrenaline alone with adrenaline plus human thrombin. Gastroenterology 111 (1996) 623-628
65. Lin H.J., Perng C.L., and Lee S.D. Is sclerosant injection mandatory after an epinephrine injection for arrest of peptic ulcer haemorrhage? A prospective, randomised, comparative study. Gut 34 (1993) 1182-1185
66. Pescatore P., Jornod P., Borovicka J., et al. Epinephrine versus epinephrine plus fibrin glue injection in peptic ulcer bleeding: a prospective randomized trial. Gastrointest Endosc 55 (2002) 348-353
67. Villanueva C., Balanzo J., Espinos J.C., et al. Endoscopic injection therapy of bleeding ulcer: a prospective and randomized comparison of adrenaline alone or with polidocanol. J Clin Gastroenterol 17 (1993) 195-200
68. Bianco M.A., Rotondano G., Marmo R., et al. Combined epinephrine and bipolar probe coagulation vs. bipolar probe coagulation alone for bleeding peptic ulcer: a randomized, controlled trial. Gastrointest Endosc 60 (2004) 910-915
69. Church N.I., Dallal H.J., Masson J., et al. A randomized trial comparing heater probe plus thrombin with heater probe plus placebo for bleeding peptic ulcer. Gastroenterology 125 (2003) 396-403
70. Cipolletta L., Bianco M.A., Marmo R., et al. Endoclips versus heater probe in preventing early recurrent bleeding from peptic ulcer: a prospective and randomized trial. Gastrointest Endosc 53 (2001) 147-151
71. Lin H.J., Hsieh Y.H., Tseng G.Y., et al. A prospective, randomized trial of endoscopic hemoclip versus heater probe thermocoagulation for peptic ulcer bleeding. Am J Gastroenterol 97 (2002) 2250-2254
72. Lin H.J., Wang K., Perng C.L., et al. Octreotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage. A prospective, randomized, controlled trial. J Clin Gastroenterol 21 (1995) 95-98
73. Lin H.J., Perng C.L., Sun I.C., et al. Endoscopic haemoclip versus heater probe thermocoagulation plus hypertonic saline-epinephrine injection for peptic ulcer bleeding. Dig Liver Dis 35 (2003) 898-902
74. Saltzman J.R., Strate L.L., Di Sena V., et al. Prospective trial of endoscopic clips versus combination therapy in upper GI bleeding (PROTECCT-UGI bleeding). Am J Gastroenterol 100 (2005) 1503-1508
75. Hartling L., McAlister F.A., Rowe B.H., et al. Challenges in systematic reviews of therapeutic devices and procedures. Ann Intern Med 142 (2005) 1100-1111
76. Laine L. Treatment of nonvariceal upper GI hemorrhage: What's happening the real world. Am J Gastroenterol 99 (2004) 1247-1249
77. Engels E.A., Schmid C.H., Terrin N., et al. Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Stat Med 19 (2000) 1707-1728
78. Sung J.J., Tsoi K.K., Lai L.H., et al. Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut 56 (2007) 1364-1373
79. Non-variceal upper gastrointestinal haemorrhage: guidelines. Gut 51 Suppl 4 (2002) iv1-iv6
80. Adler D.G., Leighton J.A., Davila R.E., et al. ASGE guideline: the role of endoscopy in acute non-variceal upper-GI hemorrhage. Gastrointest Endosc 60 (2004) 497-504
81. Khuroo M.S., Farahat K.L., and Kagevi I.E. Treatment with proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding: a meta-analysis. J Gastroenterol Hepatol 20 (2005) 11-25
82. Laine L. Systematic review of endoscopic therapy for ulcers with clots: Can a meta-analysis be misleading?. Gastroenterology 129 (2005) 2127
83. Liou T.C., Chang W.H., Wang H.Y., Lin S.C., and Shih S.C. Large-volume endoscopic injection of epinephrine plus normal saline for peptic ulcer bleeding. J Gastroenterol Hepatol 22 (2007) 996-1002
84. Marmo R., Rotondano G., Piscopo R., et al. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol 102 (2007) 279-289 quiz 469
85. Gevers A.M., De Goede E., Simoens M., et al. A randomized trial comparing injection therapy with hemoclip and with injection combined with hemoclip for bleeding ulcers. Gastrointest Endosc 55 (2002) 466-469