Transglutaminases and their substrates in biology and human diseases: 50 Years of growing

Amino Acids

Volumn 36, Issue 4, 2009, Pages 599-614

  Facchiano, Angelo ^a   Facchiano, Francesco ^b  

^a CNR   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Crosslink reaction; Enzyme substrate; G protein; TGase family

Indexed keywords

ACTIN; ALDEHYDE DEHYDROGENASE; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACTERIORHODOPSIN; BETA ENDORPHIN; BLOOD CLOTTING FACTOR 8; CADAVERINE; CELL ADHESION MOLECULE; CYSTATIN; DIAMINE; FIBRINOGEN; GLUTAMATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTAMINE; MONOAMINE; POLYAMINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 1; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 3; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 4; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 5; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 6; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 7; PUTRESCINE; SEROTONIN; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

APOPTOSIS; BIOLOGY; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CATARACT; CELIAC DISEASE; CELL ADHESION; CELL DIFFERENTIATION; CELL MOTILITY; CROSS LINKING; CYTOSKELETON; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; EPIDERMIS CELL; EPIDERMIS DISEASE; ERYTHROCYTE MEMBRANE; FERTILITY; GENERAL ASPECTS OF DISEASE; HUMAN; ICHTHYOSIS; INFERTILITY; INFLAMMATION; KERATINOCYTE; NEOPLASM; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; SKIN DISEASE; SPHEROCYTOSIS; WOUND HEALING;

DISEASE; HUMANS; SUBSTRATE SPECIFICITY; TRANSGLUTAMINASES;

EID: 62949245813     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-008-0124-8     Document Type: Review

References (178)

1. S Abe K Yamashita H Kohno Y Ohkubo 2000 Involvement of transglutaminase in the receptor-mediated endocytosis of mouse peritoneal macrophages Biol Pharm Bull 23 12 1511 1513
2. R Adany H Bardos M Antal L Modis A Sarvary S Szucs 2001 Factor XIII of blood coagulation as a nuclear crosslinking enzyme Thromb Haemost 85 5 845 851
3. D Aeschlimann M Paulsson K Mann 1992 Identification of Gln726 in nidogen as the amine acceptor in transglutaminase-catalyzed cross-linking of laminin-nidogen complexes J Biol Chem 267 16 11316 11321
4. D Aeschlimann O Kaupp M Paulsson 1995 Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate J Cell Biol 129 3 881 892
5. S Aho 2004 Many faces of periplakin: domain-specific antibodies detect the protein throughout the epidermis, explaining the multiple protein-protein interactions Cell Tissue Res 316 1 87 97
6. B Ahvazi KM Boeshans PM Steinert 2004 Crystal structure of transglutaminase 3 in complex with GMP: structural basis for nucleotide specificity J Biol Chem 279 25 26716 26725
7. U Akar B Ozpolat K Mehta J Fok Y Kondo G Lopez-Berestein 2007 Tissue transglutaminase inhibits autophagy in pancreatic cancer cells Mol Cancer Res 5 3 241 219
8. Y Ando S Imamura MK Owada R Kannagi 1991 Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids J Biol Chem 266 2 1101 1018
9. G Andringa KY Lam M Chegary X Wang TN Chase MC Bennett 2004 Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease Faseb J 18 7 932 934
10. AC Ashton JO Dolly 1997 Microtubules and microfilaments participate in the inhibition of synaptosomal noradrenaline release by tetanus toxin J Neurochem 68 2 649 658
11. GM Asijee L Muszbek J Kappelmayer J Polgar A Horvath A Sturk 1988 Platelet vinculin: a substrate of activated factor XIII Biochim Biophys Acta 954 3 303 308
12. Z Balajthy K Csomós G Vámosi A Szántó M Lanotte L Fésüs 2006 Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions Blood 108 6 2045 2054
13. E Ballestar C Abad L Franco 1996 Core histones are glutaminyl substrates for tissue transglutaminase J Biol Chem 271 31 18817 18824
14. S Beninati AB Mukherjee 1992 A novel transglutaminase-catalyzed posttranslational modification of HIV-1 aspartyl protease Biochem Biophys Res Commun 187 3 1211 1218
15. S Beninati M Piacentini ET Cocuzzi F Autuori JE Folk 1988 Covalent incorporation of polyamines as gamma-glutamyl derivatives into CHO cell protein Biochim Biophys Acta 952 3 325 333
16. S Beninati L Nicolini J Jakus A Passeggio A Abbruzzese 1995 Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A Biochem J 305 Pt 3 725 728
17. GA Berbers RW Feenstra R van den Bos WA Hoekman H Bloemendal WW de Jong 1984 Lens transglutaminase selects specific beta-crystallin sequences as substrate Proc Natl Acad Sci USA 81 22 7017 7020
18. CM Bergamini M Signorini L Poltronieri 1987 Inhibition of erythrocyte transglutaminase by GTP Biochim Biophys Acta 916 1 149 151
19. W Borth V Chang P Bishop PC Harpel 1991 Lipoprotein (a) is a substrate for factor XIIIa and tissue transglutaminase J Biol Chem 266 27 18149 18153
20. JM Bowness JE Folk R Timpl 1987 Identification of a substrate site for liver transglutaminase on the aminopropeptide of type III collagen J Biol Chem 262 3 1022 1024
21. SE Bruce I Bjarnason TJ Peters 1985 Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease Clin Sci (Lond) 68 5 573 579
22. SJ Butler M Landon 1981 Transglutaminase-catalysed incorporation of putrescine into denatured cytochrome. Preparation of a mono-substituted derivative reactive with cytochrome c oxidase Biochim Biophys Acta 670 214 221
23. E Candi E Tarcsa JJ Digiovanna JG Compton PM Elias LN Marekov 1998 A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases Proc Natl Acad Sci USA 95 5 2067 2072
24. E Candi A Paradisi A Terrinoni V Pietroni S Oddi B Cadot 2004 Transglutaminase 5 is regulated by guanine-adenine nucleotides Biochem J 381 Pt 1 313 319
25. DD Clarke MJ Mycek A Neidle H Waelsch 1957 The incorporation of amines into proteins Arch Biochem Biophys 79 338 354
26. S Clement PT Velasco SN Murthy JH Wilson TJ Lukas RD Goldman 1998 The intermediate filament protein, vimentin, in the lens is a target for cross-linking by transglutaminase J Biol Chem 273 13 7604 7609
27. AJ Cooper KR Sheu JR Burke O Onodera WJ Strittmatter AD Roses 1997 Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length Proc Natl Acad Sci USA 94 23 12604 12609
28. E Cordella-Miele L Miele AB Mukherjee 1990 A novel transglutaminase- mediated post-translational modification of phospholipase A2 dramatically increases its catalytic activity J Biol Chem 265 28 17180 17188
29. PJ Coussons SM Kelly NC Price CM Johnson B Smith L Sawyer 1991 Selective modification by transglutaminase of a glutamine side chain in the hinge region of the histidine-388-glutamine mutant of yeast phosphoglycerate kinase Biochem J 273 Pt 1 73 78
30. PJ Coussons NC Price SM Kelly B Smith L Sawyer 1992 Factors that govern the specificity of transglutaminase-catalysed modification of proteins and peptides Biochem J 282 Pt 3 929 930
31. PJ Coussons NC Price SM Kelly B Smith L Sawyer 1992 Transglutaminase catalyses the modification of glutamine side chains in the C-terminal region of bovine beta-lactoglobulin Biochem J 283 Pt 3 803 806
32. PJ Davies DR Davies A Levitzki FR Maxfield P Milhaud MC Willingham IH Pastan 1980 Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones Nature 283 5743 162 167
33. PJ Davies MM Cornwell JD Johnson A Reggianni M Myers MP Murtaugh 1984 Studies on the effects of dansylcadaverine and related compounds on receptor-mediated endocytosis in cultured cells Diabetes Care 7 Suppl 1 35 41
34. M Della Mea D Caparros-Riuz I Claparols D Serafini-Fracassini J Rigau 2004 AtPng1p. The first plant Transglutaminase Plant Physiol 135 2046 2054
35. L Dondini S Del Duca L Dall'Agata R Bassi M Gastaldelli M Della Mea 2003 Suborganellar localisation and effect of light on Helianthus tuberosus chloroplast transglutaminases and their substrates Planta 217 1 84 95
36. RF Doolittle KW Watt BA Cottrell DD Strong M Riley 1979 The amino acid sequence of the alpha-chain of human fibrinogen Nature 280 5722 464 468
37. HJ Dubbink NS Verkaik PW Faber J Trapman FH Schroder JC Romijn 1996 Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase Biochem J 315 Pt 3 901 908
38. L Eligula L Chuang ML Phillips M Motoki K Seguro A Muhlrad 1998 Transglutaminase-induced cross-linking between subdomain 2 of G-actin and the 636-642 lysine-rich loop of myosin subfragment 1 Biophys J 74 2 Pt 1 953 963
39. SC Eschenlauer AP Page 2003 The Caenorhabditis elegans ERp60 homolog protein disulfide isomerase-3 has disulfide isomerase and transglutaminase-like cross-linking activity and is involved in the maintenance of body morphology J Biol Chem 278 6 4227 4237
40. C Esposito I Caputo 2005 Mammalian transglutaminases. Identification of substrates as a key to physiological function and physiopathological relevance FEBS J 272 3 615 631
41. C Esposito P Pucci A Amoresano G Marino A Cozzolino R Porta 1996 Transglutaminase from rat coagulating gland secretion. Post-translational modifications and activation by phosphatidic acids J Biol Chem 271 44 27416 27423
42. C Esposito A Cozzolino L Mariniello P Stiuso S De Maria S Metafora 1999 Enzymatic synthesis of vasoactive intestinal peptide analogs by transglutaminase J Pept Res 53 6 626 632
43. Facchiano F, and Luini A (1990) Modification of Tetanus Toxin by Transglutaminase: Effect of Gangliosides. In Rappuoli et al (ed) Bacterial protein Toxins, Zbl. Bakt. Suppl., 19. Gustav Fisher, Stuttgart, New York
44. F Facchiano A Luini 1992 Tetanus toxin potently stimulates tissue transglutaminase. A possible mechanism of neurotoxicity J Biol Chem 267 19 13267 13271
45. F Facchiano F Benfenati F Valtorta A Luini 1993 Covalent modification of synapsin I by a tetanus toxin-activated transglutaminase J Biol Chem 268 7 4588 4591
46. F Facchiano F Valtorta F Benfenati A Luini 1993 The transglutaminase hypothesis for the action of tetanus toxin Trends Biochem Sci 18 9 327 329
47. AM Facchiano A Facchiano F Facchiano 2003 Active sequences collection (ASC) database: a new tool to assign functions to protein sequences Nucleic Acids Res 31 1 379 382
48. C Ferrandiz E Perez-Paya L Braco C Abad 1994 Gln5 selectively monodansylated substance P as a sensitive tool for interaction studies with membranes Biochem Biophys Res Commun 203 1 359 365
49. L Fesus M Piacentini 2002 Transglutaminase 2: an enigmatic enzyme with diverse functions Trends Biochem Sci 27 10 534 539
50. B Fleckenstein O Molberg SW Qiao DG Schmid F von der Mulbe K Elgstoen 2002 Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process J Biol Chem 277 37 34109 34116
51. B Fleckenstein SW Qiao MR Larsen G Jung P Roepstorff LM Sollid 2004 Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides J Biol Chem 279 17 17607 17616
52. JE Folk 1983 Mechanism and basis for specificity of transglutaminase- catalyzed epsilon-(gamma-glutamyl) lysine bond formation Adv Enzymol Relat Areas Mol Biol 54 1 56
53. JE Folk PW Cole 1965 Structural Requirements of Specific Substrates for Guinea Pig Liver Transglutaminase J Biol Chem 240 2951 2960
54. A Fontana B Spolaore A Mero FM Veronese 2008 Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase Adv Drug Deliv Rev 60 1 13 28
55. PD Fortin CT Walsh NA Magarvey 2007 A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines Nature 448 7155 824 827
56. M Ginsburg I Wajda H Waelsch 1963 Transglutaminase and histamine incorporation in vivo Biochem Pharmacol 12 251 264
57. JJ Gorman JE Folk 1980 Structural features of glutamine substrates for human plasma factor XIIIa (activated blood coagulation factor XIII) J Biol Chem 255 2 419 427
58. JJ Gorman JE Folk 1980 Transglutaminase amine substrates for photochemical labeling and cleavable cross-linking of proteins J Biol Chem 255 3 1175 1180
59. L Gorza R Menabo M Vitadello CM Bergamini F Di Lisa 1996 Cardiomyocyte troponin T immunoreactivity is modified by cross-linking resulting from intracellular calcium overload Circulation 93 10 1896 1904
60. CS Greenberg PJ Birckbichler RH Rice 1991 Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues Faseb J 5 15 3071 3077
61. M Griffin R Casadio CM Bergamini 2002 Transglutaminases: nature's biological glues Biochem J 368 Pt 2 377 396
62. PJ Groenen H Bloemendal WW de Jong 1992 The carboxy-terminal lysine of alpha B-crystallin is an amine-donor substrate for tissue transglutaminase Eur J Biochem 205 2 671 674
63. PJ Groenen JJ Grootjans NH Lubsen H Bloemendal WW de Jong 1994 Lys-17 is the amine-donor substrate site for transglutaminase in beta A3-crystallin J Biol Chem 269 2 831 833
64. PJ Groenen RH Smulders RF Peters JJ Grootjans PR van den Ijssel H Bloemendal 1994 The amine-donor substrate specificity of tissue-type transglutaminase Influence of amino acid residues flanking the amine-donor lysine residue. Eur J Biochem 220 3 795 799
65. T Halkier H Andersen A Vestergaard S Magnusson 1994 Bovine histidine-rich glycoprotein is a substrate for bovine plasma factor XIIIa Biochem Biophys Res Commun 200 1 78 82
66. D Hand D Dias LW Haynes 2000 Stabilization of collagen-tailed acetylcholinesterase in muscle cells through extracellular anchorage by transglutaminase-catalyzed cross-linking Mol Cell Biochem 204 1-2 65 76
67. G Hasegawa M Suwa Y Ichikawa T Ohtsuka S Kumagai M Kikuchi 2003 A novel function of tissue-type transglutaminase: protein disulphide isomerase Biochem J 373 Pt 3 793 803
68. JM Hettasch KA Peoples CS Greenberg 1997 Analysis of factor XIII substrate specificity using recombinant human factor XIII and tissue transglutaminase chimeras J Biol Chem 272 40 25149 25156
69. D Hohl T Mehrel U Lichti ML Turner DR Roop PM Steinert 1991 Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins J Biol Chem 266 6626 6636
70. I Hunter K Sigmundsson N Beauchemin B Obrink 1998 The cell adhesion molecule C-CAM is a substrate for tissue transglutaminase FEBS Lett 425 1 141 144
71. K Ikura K Kita I Fujita H Hashimoto N Kawabata 1998 Identification of amine acceptor protein substrates of transglutaminase in liver extracts: use of 5-(biotinamido) pentylamine as a probe Arch Biochem Biophys 356 2 280 286
72. M Jäger E Nir S Weiss 2006 Site-specific labeling of proteins for single-molecule FRET by combining chemical and enzymatic modification Protein Sci 15 3 640 646
73. CJ Jeffery 1999 Moonlighting proteins Trends Biochem Sci 24 8 11
74. CJ Jeffery 2003 Moonlighting proteins: old proteins learning new tricks Trends Genet 19 8 415 417
75. PH Jensen L Lorand P Ebbesen J Gliemann 1993 Type-2 plasminogen-activator inhibitor is a substrate for trophoblast transglutaminase and factor XIIIa. Transglutaminase-catalyzed cross-linking to cellular and extracellular structures Eur J Biochem 214 1 141 146
76. MT Kaartinen A Pirhonen A Linnala-Kankkunen PH Maenpaa 1997 Transglutaminase-catalyzed cross-linking of osteopontin is inhibited by osteocalcin J Biol Chem 272 36 22736 22741
77. MT Kaartinen S El-Maadawy NH Rasanen MD McKee 2002 Tissue transglutaminase and its substrates in bone J Bone Miner Res 17 12 2161 2173
78. P Kahlem C Terré H Green P Djian 1996 Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system Proc Natl Acad Sci USA 93 25 14580 14585
79. N Kamiya T Tanaka T Suzuki T Takazawa S Takeda K Watanabe 2003 S-peptide as a potent peptidyl linker for protein cross-linking by microbial transglutaminase from Streptomyces mobaraensis Bioconjug Chem 14 2 351 357
80. Z Keresztessy E Csosz J Hársfalvi K Csomós J Gray RN Lightowlers JH Lakey Z Balajthy L Fésüs 2006 Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2 Protein Sci 15 11 2466 2480
81. SY Kim IG Kim SI Chung PM Steinert 1994 The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity J Biol Chem 269 45 27979 27986
82. S Kimura N Aoki 1986 Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor J Biol Chem 261 33 15591 15595
83. LA Knodler R Noiva K Mehta JM McCaffery SB Aley SG Svard 1999 Novel protein-disulfide isomerases from the early-diverging protist Giardia lamblia J Biol Chem 274 42 29805 29811
84. S Kojima T Inui H Muramatsu Y Suzuki K Kadomatsu M Yoshizawa 1997 Dimerization of midkine by tissue transglutaminase and its functional implication J Biol Chem 272 14 9410 9416
85. C Larrè M Chiarello S Dudek M Chenu J Gueguen 1993 Action of transglutaminase on the constitutive polypeptides of pealegumin J Agric Food Chem 41 1816 1820
86. KN Lee PJ Birckbichler MK Patterson Jr 1989 GTP hydrolysis by guinea pig liver transglutaminase Biochem Biophys Res Commun 162 3 1370 1375
87. KN Lee MD Maxwell MK Patterson Jr PJ Birckbichler E Conway 1992 Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase-specific probe Biochim Biophys Acta 1136 1 12 16
88. KN Lee CS Lee WC Tae KW Jackson VJ Christiansen PA McKee 2000 Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase J Biol Chem 275 48 37382 37389
89. DS Lee S Matsumoto Y Matsumura T Mori 2002 Identification of the epsilon-(gamma-glutamyl)lysine cross-linking sites in alpha-lactalbumin polymerized by mammalian and microbial transglutaminases J Agric Food Chem 50 25 7412 7419
90. 2+-dependent transglutaminase activity in root and leaf tissue of monocotyledonous and dicotyledonous plants Plant Physiol 117 3 1115 11123
91. L Lorand SM Conrad 1984 Transglutaminases Mol Cell Biochem 58 9 35
92. L Lorand KN Parameswaran P Stenberg YS Tong PT Velasco NA Jonsson 1979 Specificity of guinea pig liver transglutaminase for amine substrates Biochemistry 18 9 1756 1765
93. L Lorand PT Velasco SN Murthy J Wilson KN Parameswaran 1992 Isolation of transglutaminase-reactive sequences from complex biological systems: a prominent lysine donor sequence in bovine lens Proc Natl Acad Sci USA 89 23 11161 11163
94. W Lu A Strohecker JH Ou Jh 2001 Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase J Biol Chem 276 51 47993 47999
95. GW Lynch HS Slayter BE Miller J McDonagh 1987 Characterization of thrombospondin as a substrate for factor XIII transglutaminase J Biol Chem 262 4 1772 1778
96. RB Maccioni NW Seeds 1986 Transglutaminase and neuronal differentiation Mol Cell Biochem 69 2 161 168
97. A Madi Z Kele T Janaky M Punyiczki L Fesus 2001 Identification of protein substrates for transglutaminase in Caenorhabditis elegans Biochem Biophys Res Commun 283 4 964 968
98. A Madi R Hoffrogge B Blasko MO Glocker L Fesus 2004 Amine donor protein substrates for transglutaminase activity in Caenorhabditis elegans Biochem Biophys Res Commun 315 4 1064 1069
99. SA Mahoney M Perry A Seddon P Bohlen L Haynes 1996 Transglutaminase forms midkine homodimers in cerebellar neurons and modulates the neurite-outgrowth response Biochem Biophys Res Commun 224 1 147 152
100. SA Mahoney M Wilkinson S Smith LW Haynes 2000 Stabilization of neurites in cerebellar granule cells by transglutaminase activity: identification of midkine and galectin-3 as substrates Neuroscience 101 1 141 155
101. G Mamone P Ferranti D Melck F Tafuro L Longobardo L Chianese 2004 Susceptibility to transglutaminase of gliadin peptides predicted by a mass spectrometry-based assay FEBS Lett 562 1-3 177 182
102. LM Mandrusiak LK Beitel X Wang TC Scanlon E Chevalier-Larsen DE Merry 2003 Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor Hum Mol Genet 12 13 1497 1506
103. R Manjunath SI Chung AB Mukherjee 1984 Crosslinking of uteroglobin by transglutaminase Biochem Biophys Res Commun 121 1 400 407
104. G Mantile L Miele E Cordella-Miele G Singh SL Katyal AB Mukherjee 1993 Human Clara cell 10-kDa protein is the counterpart of rabbit uteroglobin J Biol Chem 268 27 20343 20351
105. L Mariniello C Esposito P Di Pierro A Cozzolino P Pucci R Porta 1993 Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro Eur J Biochem 215 1 99 104
106. L Mariniello C Esposito V Gentile R Porta 1993 Transglutaminase covalently incorporates amines into human immunodeficiency virus envelope glycoprotein gp120 in vitro Int J Pept Protein Res 42 2 204 206
107. M Masuda L Betancourt T Matsuzawa T Kashimoto T Takao Y Shimonishi Y Horiguchi 2000 Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin EMBO J 19 4 521 530
108. Y Matsuda T Koshiba T Osaki H Suyama F Arisaka Y Toh S Kawabata 2007 An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh J Biol Chem 282 52 37316 37324
109. MF Mazzeo B De Giulio S Senger M Rossi A Malorni RA Siciliano 2003 Identification of transglutaminase-mediated deamidation sites in a recombinant alpha-gliadin by advanced mass-spectrometric methodologies Protein Sci 12 11 2434 2442
110. RP McDonagh J McDonagh TE Petersen HC Thogersen K Skorstengaard L Sottrup-Jensen 1981 Amino acid sequence of the factor XIIIa acceptor site in bovine plasma fibronectin FEBS Lett 127 2 174 178
111. B Mehul S Bawumia RC Hughes 1995 Cross-linking of galectin 3, a galactose-binding protein of mammalian cells, by tissue-type transglutaminase FEBS Lett 360 2 160 164
112. S Mishra LJ Murphy 2004 Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase J Biol Chem 279 23 23863 23868
113. O Molberg SN McAdam R Korner H Quarsten C Kristiansen L Madsen 1998 Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Nat Med 4 6 713 717
114. SB Mortensen L Sottrup-Jensen HF Hansen D Rider TE Petersen S Magnusson 1981 Sequence location of a putative transglutaminase crosslinking site in human alpha 2-macroglobulin FEBS Lett 129 2 314 317
115. DF Mosher PE Schad 1979 Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa J Clin Invest 64 3 781 787
116. SN Murthy J Wilson Y Zhang L Lorand 1994 Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase J Biol Chem 269 36 22907 22911
117. SN Murthy JH Wilson TJ Lukas J Kuret L Lorand 1998 Cross-linking sites of the human tau protein, probed by reactions with human transglutaminase J Neurochem 71 6 2607 2614
118. SN Murthy JH Wilson TJ Lukas Y Veklich JW Weisel L Lorand 2000 Transglutaminase-catalyzed crosslinking of the Aalpha and gamma constituent chains in fibrinogen Proc Natl Acad Sci USA 97 1 44 48
119. MJ Mycek DD Clarke A Neidle H Waelsch 1959 Amine incorporation into insulin as catalyzed by transglutaminase Arch Biochem Biophys 84 528 540
120. OW Nadeau KW Traxler GM Carlson 1998 Zero-length crosslinking of the beta subunit of phosphorylase kinase to the N-terminal half of its regulatory alpha subunit Biochem Biophys Res Commun 251 2 637 641
121. H Nakaoka DM Perez KJ Baek T Das A Husain K Misono 1994 Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function Science 264 5165 1593 1596
122. Z Nemes Jr R Adany M Balazs P Boross L Fesus 1997 Identification of cytoplasmic actin as an abundant glutaminyl substrate for tissue transglutaminase in HL-60 and U937 cells undergoing apoptosis J Biol Chem 272 33 20577 20583
123. Z Nemes LN Marekov PM Steinert 1999 Involucrin cross-linking by transglutaminase 1. Binding to membranes directs residue specificity J Biol Chem 274 16 11013 11021
124. WF Nieuwenhuizen HL Dekker LJ de Koning T Groneveld CG de Koster GA de Jong 2003 Modification of glutamine and lysine residues in holo and apo alpha-lactalbumin with microbial transglutaminase J Agric Food Chem 51 24 7132 7139
125. WF Nieuwenhuizen HL Dekker T Groneveld CG de Koster GA de Jong 2004 Transglutaminase-mediated modification of glutamine and lysine residues in native bovine beta-lactoglobulin Biotechnol Bioeng 85 3 248 258
126. S Oliverio A Amendola F Di Sano MG Farrace L Fesus Z Nemes 1997 Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis Mol Cell Biol 17 10 6040 6048
127. JM Orban LB Wilson JA Kofroth MS El-Kurdi TM Maul DA Vorp 2004 Crosslinking of collagen gels by transglutaminase J Biomed Mater Res 68A 4 756 762
128. S Orru M Ruoppolo S Francese L Vitagliano G Marino C Esposito 2002 Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase Protein Sci 11 1 137 146
129. M Ota A Sawa N Nio Y Ariyoshi 1999 Enzymatic ligation for synthesis of single-chain analogue of monellin by transglutaminase Biopolymers 50 2 193 200
130. P Ouyang 1999 Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus Biochem Biophys Res Commun 263 1 192 200
131. X Peng Y Zhang H Zhang S Graner JF Williams ML Levitt 1999 Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3 FEBS Lett 446 1 35 39
132. E Perez-Paya E Thiaudiere C Abad J Dufourcq 1991 Selective labelling of melittin with a fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase FEBS Lett 278 1 51 54
133. A Peter H Lilja A Lundwall J Malm 1998 Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase Eur J Biochem 252 2 216 221
134. JH Pincus H Waelsch 1968 The specificity of transglutaminase. I. Human hemoglobin as a substrate for the enzyme Arch Biochem Biophys 126 1 34 43
135. JH Pincus H Waelsch 1968 The specificity of transglutaminase. II. Structural requirements of the amine substrate Arch Biochem Biophys 126 1 44 52
136. JL Piper GM Gray C Khosla 2002 High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue Biochemistry 41 1 386 393
137. L Piredda MG Farrace M Lo Bello W Malorni G Melino R Petruzzelli 1999 Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis Faseb J 13 2 355 364
138. R Porta C Esposito S Metafora A Malorni P Pucci R Siciliano 1991 Mass spectrometric identification of the amino donor and acceptor sites in a transglutaminase protein substrate secreted from rat seminal vesicles Biochemistry 30 12 3114 3120
139. CW Prince D Dickie CL Krumdieck 1991 Osteopontin, a substrate for transglutaminase and factor XIII activity Biochem Biophys Res Commun 177 3 1205 1210
140. P Pucci A Malorni G Marino S Metafora C Esposito R Porta 1988 Beta-endorphin modification by transglutaminase in vitro: identification by FAB/MS of glutamine-11 and lysine-29 as acyl donor and acceptor sites Biochem Biophys Res Commun 154 2 735 740
141. LK Rasmussen ES Sorensen TE Petersen J Gliemann PH Jensen 1994 Identification of glutamine and lysine residues in Alzheimer amyloid beta A4 peptide responsible for transglutaminase-catalysed homopolymerization and cross-linking to alpha 2 M receptor FEBS Lett 338 2 161 166
142. LK Rasmussen L Ellgaard PH Jensen ES Sorensen 1999 Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein J Protein Chem 18 1 69 73
143. H Ritchie LA Robbie S Kinghorn R Exley NA Booth 1999 Monocyte plasminogen activator inhibitor 2 (PAI-2) inhibits u-PA-mediated fibrin clot lysis and is cross-linked to fibrin Thromb Haemost 81 1 96 103
144. NA Robinson RL Eckert 1998 Identification of transglutaminase-reactive residues in S100A11 J Biol Chem 273 5 2721 2728
145. K Robitaille A Daviau J Tucholski GV Johnson C Rancourt R Blouin 2004 Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis Cell Death Differ 11 5 542 549
146. M Ruse A Lambert N Robinson D Ryan KJ Shon RL Eckert 2001 S100A7, S100A10, and S100A11 are transglutaminase substrates Biochemistry 40 10 3167 3173
147. D Safer TR Sosnick M Elzinga 1997 Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends Biochemistry 36 19 5806 5816
148. K Sakai WH Busby Jr JB Clarke DR Clemmons 2001 Tissue transglutaminase facilitates the polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) and leads to loss of IGFBP-1's ability to inhibit insulin-like growth factor-I-stimulated protein synthesis J Biol Chem 276 12 8740 8745
149. A Sarvary S Szucs I Balogh A Becsky H Bardos M Kavai 2004 Possible role of factor XIII subunit A in Fcgamma and complement receptor-mediated phagocytosis Cell Immunol 228 2 81 90
150. H Sato 2002 Enzymatic procedure for site-specific pegylation of proteins Adv Drug Deliv Rev 54 4 487 504
151. H Sato N Yamada N Shimba Y Takahara 2000 Unique substrate specificities of two adjacent glutamine residues in EAQQIVM for transglutaminase: identification and characterization of the reaction products by electrospray ionization tandem mass spectrometry Anal Biochem 281 1 68 76
152. H Sato E Hayashi N Yamada M Yatagai Y Takahara 2001 Further studies on the site-specific protein modification by microbial transglutaminase Bioconjug Chem 12 5 701 710
153. G Schmidt UM Goehring J Schirmer M Lerm K Aktories 1999 Identification of the C-terminal part of Bordetella dermonecrotic toxin as a transglutaminase for rho GTPases J Biol Chem 274 45 31875 31881
154. J Schrode JE Folk 1978 Transglutaminase-catalyzed cross-linking through diamines and polyamines J Biol Chem 253 14 4837 4840
155. A Seitz F Schneider R Pasternack HL Fuchsbauer N Hampp 2001 Enzymatic cross-linking of purple membranes catalyzed by bacterial transglutaminase Biomacromolecules 2 1 233 238
156. M Simon H Green 1988 The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin J Biol Chem 263 34 18093 18098
157. US Singh JW Erickson RA Cerione 1995 Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei Biochemistry 34 48 15863 15871
158. US Singh MT Kunar YL Kao KM Baker 2001 Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2 Embo J 20 10 2413 2423
159. K Skorstengaard T Halkier P Hojrup D Mosher 1990 Sequence location of a putative transglutaminase cross-linking site in human vitronectin FEBS Lett 262 2 269 274
160. ES Sorensen LK Rasmussen L Moller PH Jensen P Hojrup TE Petersen 1994 Localization of transglutaminase-reactive glutamine residues in bovine osteopontin Biochem J 304 Pt 1 13 16
161. Y Sugimura M Hosono F Wada T Yoshimura M Maki K Hitomi 2006 Screening for the preferred substrate sequence of transglutaminase using a phage-displayed peptide library: identification of peptide substrates for TGASE 2 and Factor XIIIA J Biol Chem 281 26 17699 17706
162. Z Szondy Z Sarang P Molnar T Nemeth M Piacentini PG Mastroberardino 2003 Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells Proc Natl Acad Sci USA 100 13 7812 7817
163. S Taguchi KI Nishihama K Igi K Ito H Taira M Motoki 2000 Substrate specificity analysis of microbial transglutaminase using proteinaceous protease inhibitors as natural model substrates J Biochem (Tokyo) 128 3 415 425
164. R Takashi 1988 A novel actin label: a fluorescent probe at glutamine-41 and its consequences Biochemistry 27 938 943
165. M Takahashi T Tezuka N Katunuma 1996 Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis Arch Biochem Biophys 329 1 123 126
166. M Taki M Shiota K Taira 2004 Transglutaminase-mediated N- and C-terminal fluorescein labeling of a protein can support the native activity of the modified protein Protein Eng Des Sel 17 2 119 126
167. T Tamaki N Aoki 1982 Cross-linking of alpha 2-plasmin inhibitor to fibrin catalyzed by activated fibrin-stabilizing factor J Biol Chem 257 24 14767 14772
168. K Teshigawara R Kannagi N Noro T Masuda 1985 Possible involvement of transglutaminase in endocytosis and antigen presentation Microbiol Immunol 29 8 737 750
169. VD Truong DA Clare GL Catignani HE Swaisgood 2004 Cross-linking and rheological changes of whey proteins treated with microbial transglutaminase J Agric Food Chem 52 5 1170 1176
170. S Umar F Malavasi K Mehta 1996 Post-translational modification of CD38 protein into a high molecular weight form alters its catalytic properties J Biol Chem 271 27 15922 15927
171. T Usui J Takagi Y Saito 1993 Propolypeptide of von Willebrand factor serves as a substrate for factor XIIIa and is cross-linked to laminin J Biol Chem 268 17 12311 12316
172. LW Vader A de Ru Y van der Wal YM Kooy W Benckhuijsen ML Mearin 2002 Specificity of tissue transglutaminase explains cereal toxicity in celiac disease J Exp Med 195 5 643 649
173. Z Valnickova JJ Enghild 1998 Human procarboxypeptidase U, or thrombin-activable fibrinolysis inhibitor, is a substrate for transglutaminases Evidence for transglutaminase-catalyzed cross-linking to fibrin. J Biol Chem 273 42 27220 27224
174. E Verderio C Gaudry S Gross C Smith S Downes M Griffin 1999 Regulation of cell surface tissue transglutaminase: effects on matrix storage of latent transforming growth factor-beta binding protein-1 J Histochem Cytochem 47 11 1417 1432
175. V Violante A Luongo I Pepe S Annunziata V Gentile 2001 Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases Brain Res Bull 56 3-4 169 172
176. DJ Walther JU Peter S Winter M Holtje N Paulmann M Grohmann 2003 Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release Cell 115 7 851 862
177. GM Zainelli CA Ross JC Troncoso JK Fitzgerald NA Muma 2004 Calmodulin regulates transglutaminase 2 cross-linking of huntingtin J Neurosci 24 8 1954 1961
178. PL Zeeuwen IM Van Vlijmen-Willems BJ Jansen G Sotiropoulou JH Curfs JF Meis 2001 Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase J Invest Dermatol 116 5 693 701