Further studies on the site-specific protein modification by microbial transglutaminase

Bioconjugate Chemistry

Volumn 12, Issue 5, 2001, Pages 701-710

  Sato, H ^a   Hayashi, E ^a   Yamada, N ^a   Yatagai, M ^a   Takahara, Y ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG DELIVERY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RECOMBINANT PROTEINS;

ALKYLAMINE; GUINEA PIGS; HUMAN INTERLEUKIN; INTERLEUKIN2 (IL2); MICROBIAL TRANSGLUTAMINASE; PIG LIVER; PROTEIN MODIFICATIONS; SITE-SPECIFIC; SITE-SPECIFIC MODIFICATIONS; TRANSGLUTAMINASES;

CATALYSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA PORCELLUS; SUS SCROFA;

EID: 0034809776     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc000132h     Document Type: Article

References (37)

1. Cancer therapy with chemically modified enzymes. I. Antitumor properties of poly(ethylene glycol)-asparaginase conjugates
2. Chemical modification of recombinant interleukin 2 by poly(ethyleneglycol) increases its potency in the murine Meth A sarcoma model
3. Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism
4. Mannosylated superoxide dismutase inhibits hepatic reperfusion injury in rats
5. Site-directed pegylation of recombinant interleukin-2 at its glycosylation site
6. Site-specific conjugation of a temperature-sensitive polymer to a genetically engineered protein
7. Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with poly(ethylene glycol) in a site-specific manner
8. Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine
9. Construction of protein analogues by site-specific condensation of unprotected fragments
10. Site-specific modification of interleukin-2 by the combined use of genetic engineering techniques and transglutaminase
11. Unique substrate specificities of two adjacent glutamine residues in EAQQIVM for transglutaminase: Identification and characterization of the reaction products by electrospray ionization tandem mass spectrometry
12. Transglutaminase-mediated dual and site-specific incorporation of poly(ethylene glycol) derivatives into a chimeric interleukin-2
13. Primary structure of microbial transglutaminase from Streptoverticillium sp. strain s-8112
14. Purification and characterization of a novel transglutaminase derived from microorganisms
15. Hepatic accumulation of glutamic acid branched neogalactosyllipid modified liposomes
16. Carbohydrate-specific receptors of the liver
17. The asialoglycoprotein receptor: A model for endocytic transport receptors
18. Characterization of disulfide bonds in recombinant proteins: Reduced human interleukin 2 in inclusion bodies and its oxidative refolding
19. T cell growth factor: Parameters of production and a quantitative microassay for activity
20. Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: Identification of a functional cysteine essential for activity
21. 2+-independent microbial transglutaminase
22. Mechanism and basis for specificity of transglutaminase-catalyzed epsilon-(gamma-glutamyl) lysine bond formation
23. Specificity of guinea pig liver transglutaminase for amine substrates
24. Structural features of glutamine substrates for transglutaminases. Role of extended interactions in the specificity of human plasma factor XIIIa and of the guinea pig liver enzyme
25. Three-dimensional structure of interleukin-2
26. Identification of Gln726 in nidogen as the amine acceptor in transglutaminase-catalyzed cross-linking of laminin-nidogen complexes
27. The structure of melittin. II. Interpretation of the structure
28. X-ray analysis of glucagon and its relationship to receptor binding
29. The solution structure of the F42A mutant of human interleukin 2
30. Unraveling the structure of IL-2
31. Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein?
32. Control of in vivo fate of albumin derivatives utilizing combined chemical modification
33. Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes
34. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand
35. Cholesterol derivative of a new triantennary cluster galactoside directs low- and high-density lipoproteins to the parenchymal liver cell
36. Design and synthesis of novel amphiphilic dendric galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor