Homocysteine-induced toxicity increases TG2 expression in Neuro2a cells

Amino Acids

Volumn 36, Issue 4, 2009, Pages 725-730

  Curro M ^a   Condello, S ^a   Caccamo, D ^a   Ferlazzo, N ^a   Parisi, G ^a   Ientile, R ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Homocysteine; Neuro2a cells; NF B; ROS; Transglutaminases

Indexed keywords

CYSTAMINE; HOMOCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; REACTIVE OXYGEN METABOLITE; SN 50;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; GEL MOBILITY SHIFT ASSAY; INCUBATION TIME; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; CYSTAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; HOMOCYSTEINE; ISOENZYMES; MICE; NF-KAPPA B; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSGLUTAMINASES; TUMOR CELLS, CULTURED;

EID: 62949223216     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-008-0122-x     Document Type: Article

References (19)

1. AA Boldyrev P Johnson 2007 Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease J Alzheimers Dis 11 219 228
2. D Caccamo A Campisi H Marini EB Adamo G Li Volti F Squadrito R Ientile 2005 Glutamate promotes NF-kappaB pathway in primary astrocytes: protective effects of IRFI 016, a synthetic vitamin E analogue Exp Neurol 193 377 383
3. D Caccamo A Campisi M Currò V Bramanti M Tringali G Li Volti A Vanella R Ientile 2005 Antioxidant treatment inhibited glutamate-evoked NF-kappaB activation in primary astroglial cell cultures Neurotoxicology 26 915 921
4. A Campisi D Caccamo G Li Volti M Currò G Parisi R Avola A Vanella R Ientile 2004 Glutamate-evoked redox state alterations are involved in tissue transglutaminase up-regulation in primary astrocyte cultures FEBS Lett 578 80 84
5. JG Dickhout SK Sood RC Austin 2007 Role of endoplasmic reticulum calcium disequilibria in the mechanism of homocysteine-induced ER stress Antioxid Redox Signal 9 1863 1873
6. L Fésus Z Szondy 2005 Transglutaminase 2 in the balance of cell death and survival FEBS Lett 579 3297 3302
7. G Gloire S Legrand-Poels J Piette 2006 NF-kappaB activation by reactive oxygen species: 15 years later Biochem Pharmacol 72 1493 1505
8. M Griffin R Casadio CM Bergamini 2002 Transglutaminases: nature's biological glues Biochem J 368 377 396
9. A Hernanz M De la Fuente M Navarro A Frank 2007 Plasma aminothiol compounds, but not serum tumor necrosis factor receptor II and soluble receptor for advanced glycation end products, are related to the cognitive impairment in Alzheimer's disease and mild cognitive impairment patients Neuroimmunomodulation 14 163 167
10. R Ientile D Caccamo V Macaione V Torre S Macaione 2002 NMDA-evoked exctotoxicity increases tissue transglutaminase in cerebellar granule cells Neuroscience 115 723 729
11. R Ientile D Caccamo MC Marciano M Currò C Mannucci A Campisi G Calapai 2004 Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia Neurosci Lett 363 173 177
12. B Lenz S Bleich S Beutler B Schlierf K Schwager U Reulbach J Kornhuber D Bönsch 2006 Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites Exp Cell Res 312 4049 4055
13. MP Mattson TB Shea 2003 Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders Trends Neurosci 26 137 146
14. NA Muma 2007 Transglutaminase is linked to neurodegenerative diseases J Neuropathol Exp Neurol 66 258 263
15. B Nicholas P Smethurst E Verderio R Jones M Griffin 2003 Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity Biochem J 371 413 422
16. M Piacentini A Amendola F Ciccosanti L Falasca MG Farrace PG Mastroberardino R Nardacci S Oliverio L Piredda C Rodolfo F Autuori 2005 Type 2 transglutaminase and cell death Prog Exp Tumor Res 38 58 74
17. Q Ruan GV Johnson 2007 Transglutaminase 2 in neurodegenerative disorders Front Biosci 12 891 904
18. J Zhang M Lesort RP Guttmann GVW Johnson 1998 Modulation of the in situ activity of tissue transglutaminase by calcium and GTP J Biol Chem 273 2288 2295
19. E Zieminska E Matyja H Kozlowska A Stafiej JW Lazarewicz 2006 Excitotoxic neuronal injury in acute homocysteine neurotoxicity: role of calcium and mitochondrial alterations Neurochem Int 48 491 497