Unique expression of connexins in the human cochlea

Hearing Research

Volumn 250, Issue 1-2, 2009, Pages 55-62

  Liu, Wei ^a,b   Boström, Marja ^a   Kinnefors, Anders ^a   Rask Andersen, Helge ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Connexin; Gap junction channel; Human cochlea; Human spiral ganglion; Immunohistochemistry; Speech signal processing

Indexed keywords

COCHLEA; COCHLEAR NERVE; CONNEXIN 43; CONNEXINS; DEAFNESS; GAP JUNCTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; MUTATION; SIGNAL TRANSDUCTION; SPIRAL GANGLION; TISSUE DISTRIBUTION;

EID: 62949184119     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2009.01.010     Document Type: Article

References (32)

1. Bennett M.V., and Zukin R.S. Electrical coupling and neuronal synchronization in the mammalian brain. Neuron 41 (2004) 495-511
2. Beltramello M., Piazza V., Bukauskas F.F., Pozzan T., and Mammano F. Impaired permeability to Ins (1, 4, 5) P3 in a mutant connexin underlies recessive hereditary deafness. Nat. Cell Biol. 7 (2005) 63-69
3. Cohen-Salmon M., Ott T., Michel V., Hardelin J.P., Perfettini I., Eybalin M., Wu T., Marcus D.C., Wangemann P., Willecke K., and Petit C. Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr. Biol. 12 (2002) 1106-1111
4. Cohn E.S., and Kelley P.M. Clinical phenotype and mutations in connexin 26 (DFNB1/GJB2), the most common cause of childhood hearing loss. Am. J. Med. Genet. 89 (1999) 130-136
5. Condorelli D.F., Parenti R., Spinella F., Trovato-Salinaro A., Belluardo N., Venera C., and Cicirata F. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur. J. Neurosci. 10 (1998) 1202-1208
6. Connors B., and Long M.A. Electrical synapses in the mammalian brain. Ann. Rev. Neurosci. 27 (2004) 393-418
7. del Castillo I., Villamar M., Moreno-Pelayo M.A., del Castillo F.J., Alvarez A., Telleria D., Menendez I., and Moreno F. A deletion involving the connexin 30 gene in nonsyndromic hearing impairment. N. Engl. J. Med. 346 (2002) 243-249
8. Forge A., Becker D., Casalotti S., Edwards J., Marziano N., and Nevill G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessment of connexin composition in mammals. J. Comp. Neurol. 467 (2003) 207-231
9. Gibson J.R., Beierlein M., and Connors B.W. Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402 (1999) 75-79
10. Grifa A., Wagner C.A., D'Ambrosio L., Melchionda S., Bernardi F., Lopez-Bigas N., Rabionet R., Arbones M., Monica M.D., Estivill X., Zelante L., Lang F., and Gasparini P. Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus. Nat. Genet. 23 (1999) 16-18
11. Han Y., and Massey S.C. Electrical synapses in retinal ON cone bipolar cells: subtype-specific expression of connexins. Proc. Natl. Acad. Sci. USA 102 (2005) 13313-13318
12. Hernandez V.H., Bortolozzi M., Pertegato V., Beltramello M., Giarin M., Zaccolo M., Pantano S., and Mammano F. Unitary permeability of gap junction channels to second messengers measured by FRET microscopy. Nat. Methods 4 (2007) 353-358
13. Hormuzdi S.G., Filippov M.A., Mitropoulou G., Monyer H., and Bruzzone R. Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks. Biochim. Biophys. Acta 1662 (2004) 113-137
14. Horowitz S.S., Stamper S.A., and Simmons J.A. Neuronal connexin expression in the cochlear nucleus of big brown bats. Brain Res. 1197 (2008) 76-84
15. Jagger D.J., and Forge A. Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea. J. Neurosci. 26 (2006) 1260-8126
16. Jun A.I., McGuirt W.T., Hinojosa R., Green G.E., Fischel-Ghodsian N., and Smith R.J.H. Temporal bone histopathology in connexin 26 - related hearing loss. Laryngoscope 110 (2000) 269-275
17. Kammen-Jolly K., Ichiki H., Scholtz A.W., Gsenger M., Kreczy A., and Schrott-Fischer A. Connexin 26 in human fetal development of the inner ear. Hear. Res. 160 1-2 (2001) 15-21
18. Kandel E.R., and Michael V.L. Bennett and the cellular study of neural systems at Albert Einstein and Woods Hole. Brain Res. Brain Res. Rev. 32 (2000) 3-5
19. Kelsell D.P., Dunlop J., Stevens H.P., Lench N.J., Liang J.N., Parry G., Mueller R.F., and Leigh I.M. Connexin 26 mutations in hereditary non-syndromic sensorineural deafness. Nature 387 (1997) 80-83
20. Kikuchi T., Kimura R.S., Paul D.L., and Adams J.C. Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis. Anat. Embryol. 191 (1995) 101-118
21. Landisman C.E., Long M.A., Beierlein M., Deans M.R., Paul D.L., and Connors B.W. Electrical synapses in the thalamicreticular nucleus. J. Neurosci. 22 (2002) 1002-1009
22. Lautermann J., Frank H.G., Jahnke K., Traub O., and Winterhager E. Developmental expression patterns of connexin26 and -30 in the rat cochlea. Dev. Genet. 25 (1999) 306-311
23. Maeda Y., Fukushima K., Nishizaki K., and Smith R.J.H. In vitro and in vivo suppression of GJB2 expression by RNA interference. Hum. Mol. Genet. 14 (2005) 1641-1650
24. Nagy J.I., Patel D., Ochalski P.A.Y., and Stelmack G.L. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Neuroscience 88 (1999) 447-468
25. Placantonakis D.G., Bukovsky A.A., Zeng X.H., Kiem H.P., and Welsh J.P. Fundamental role of inferior olive connexin 36 in muscle coherence during tremor. Proc. Natl. Acad. Sci. USA 101 (2004) 7164-7169
26. Rask-Andersen H., Tylstedt S., Kinnefors A., and Illing R. Synapses on human spiral ganglion cells: a transmission electron microscopy and immunohistochemical study. Hear. Res. 141 (2000) 1-11
27. Sohl G., and Willecke K. Gap junctions and the connexin protein family. Cardiovasc. Res. 62 (2004) 228-232
28. 2+ signaling than homomeric counterparts. Am. J. Physiol. Cell Physiol. 288 (2005) C613-C623
29. Teubner B., Michel V., Pesch J., Lautermann J., Cohen Salmon M., Sohl G., Jahnke K., Winterhager E., Herberhold C., Hardelin J.P., Petit C., and Willecke K. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum. Mol. Genet. 12 (2003) 13-21
30. Weickert S., Ray A., Zoidl G., and Dermietzel R. Expression of neural connexins and pannexin1 in the hippocampus and inferior olive: a quantitative approach. Brain Res. Mol. Brain Res. 133 (2005) 102-109
31. Yum S.W., Zhang J., Valiunas V., Kanaporis G., Brink P.R., White T.W., and Scherer S.S. Human connexin26 and connexin30 form functional heteromeric and heterotypic channels. Am. J. Physiol. Cell Physiol. 293 (2007) 1032-1048
32. Zhang Y., Tang W., Ahmad S., Sipp J.A., Chen P., and Lin X. Gap junction mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions. Proc. Natl. Acad. Sci. USA 102 (2005) 15201-15206