Vasomotor and permeability effects of bradykinin in the cerebral microcirculation

Immunopharmacology

Volumn 33, Issue 1-3, 1996, Pages 257-263

  Wahl, M ^a   Whalley, E T ^b   Unterberg, A ^a   Schilling, L ^a   Parsons, A A ^c   Baethmann, A ^d   Young, A R ^e  

^a Department of Physiology ^*  (Germany)

^b Cortech ^*  (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Institute Experimental Surgery   (Germany)

^e GIP CYCERON   (France)

Author keywords

autacoids; blood brain barrier; brain oedema; cerebral microcirculation; kallikrein kinin

Indexed keywords

BRADYKININ; BRADYKININ ANTAGONIST; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; BRADYKININ DERIVATIVE; CAPTOPRIL; DELTIBANT; DIPEPTIDYL CARBOXYPEPTIDASE; FLUORESCEIN SODIUM; FREE RADICAL; HYDROGEN PEROXIDE; KININASE 2 INHIBITOR; LEUKOTRIENE; NITRIC OXIDE; PROSTANOID; UNCLASSIFIED DRUG;

ARTERIOLE; ARTERY DILATATION; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; BRAIN MICROCIRCULATION; CAT; CELL MEMBRANE; CONFERENCE PAPER; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; KALLIKREIN KININ SYSTEM; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

EID: 0030175617     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(96)00068-9     Document Type: Conference Paper

References (67)

1. Almenoff J, Wilk S, Orlowski M. Membrane bound pituitary metalloendopeptidase: apparent identity to enkephalinase. Biochem. Biophys. Res. Commun. 1981; 102: 206-214.
2. Baethmann A, Oettinger W, Rothenfußer W, Kempski O, Unterberg A, Geiger R. Brain edema factors: current state with particular reference to plasma constituents and glutamate. In: Cervos-Navarro J, Ferszt R, Eds., Advances in Neurology, Brain Edema. Vol. 28. New York: Raven Press, 1980: 171-195.
3. Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol. 1990; 429: 47-62.
4. Chao J, Woodley C, Chao L, Margolius HS. Identification of tissue kallikrein in brain and in the cell-free translation product encoded by brain mRNA. J. Biol. Chem. 1983; 258: 15173-15178.
5. Correa FMA, Plunkett LM, Saavedra JM. Quantitative distribution of angiotensin-converting enzyme (kinin-ase II) in discrete areas of the rat brain by autoradiography with computerized microdensitometry. Brain Res. 1986; 375: 259-266.
6. Dacey RG Jr, Bassett JE, Takayasu M. Vasomotor responses of rat intracerebral arterioles to vasoactive intestinal peptide, substance P, neuropeptide Y, and bradykinin. J. Cereb. Blood Flow Metab. 1988; 8: 254-261.
7. Ellis EF, Heizer ML, Hambrecht GS, Holt SA, Stewart JM, Vavrek RJ. Inhibition of bradykinin-induced and kallikrein-induced cerebral arteriolar dilation by a specific bradykinin antagonist. Stroke 1987; 18: 792-795.
8. Ellis EF, Holt SA, Wei EP, Kontos HA. Kinins induced abnormal vascular reactivity. Am. J. Physiol. 1988; 255: H397-H400.
9. Ellis EF, Chao J, Heizer ML. Brain kininogen following experimental brain injury: evidence for a secondary event. J. Neurosurg. 1989; 71: 437-442.
10. Fuxe K, Ganten D, Köhler C, Sehüll B, Speck G. Evidence for differential localization of angiotensin-1 converting enzyme and renin in the corpus striatum of rat. Acta Physiol. Scand. 1980; 110: 321-323.
11. Guillot FL, Audus KL. Angiotensin peptide regulation of fluid-phase endocytosis in brain microvessel endothelial cell monolayers. J. Cereb. Blood Flow Metab. 1990; 10: 827-834.
12. Inamura T, Black KL. Bradykinin selectively opens blood-tumor barrier in experimental brain tumors. J. Cereb. Blood Flow Metab. 1994; 14: 862-870.
13. Kamitani T, Little M, Ellis EF. Evidence for a possible role of the brain kallikrein-kinin system in the modulation of the cerebral circulation. Circ. Res. 1985; 57: 545-552.
14. Kamiya T, Katayama Y, Inamura K, Shimizu J, Obo R, Iida S, Kashiwagi F, Terashi A. Activation of bradykinin augments ischemic brain edema. J. Cereb. Blood Flow Metab. 1989; 9 Suppl. 1: S73.
15. Kariya K, Kawauchi R, Okamoto H. Regional distribution of kininase in rat brain. J. Neurochem. 1981; 36: 2086-2988.
16. Kariya K, Okamoto H, Kira K. Kianin-forming enzyme in rat brain mitochondria fraction and biological activtiy of a kinin released from rat plasma kininogen by this enzyme. Jpn. J. Pharmacol. 1984; 34: 203-210.
17. 1-vasopressinergic receptors. J. Pharmacol. Exp. Ther. 1986; 236: 166-170.
18. Katusic ZS, Marshall JJ, Kontos HA, Vanhoutte PM. Similar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxide. Am. J. Physiol. 1989; 257: H1235-H1239.
19. Kontos HA, Wei EP, Povlishock JT, Christman CW. Oxygen radicals mediate the cerebral arteriolar dilatation from arachidonate and bradykinin in cats. Circ. Res. 1984; 55: 295-303.
20. Kontos HA, Wei KP, Kukrejac R, Ellis FE, Hess LM. Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine. Am. J. Physiol. 1990; 258: H1261-H1266.
21. Maier-Hauff K, Baethmann AJ, Lange M, Schürer L, Unterberg A. The kallikrein-kinin system as a mediator in vasogenic brain edema, Part 2. Studies on kinin formation in focal and perifocal brain tissue. J. Neurosurg. 1984; 61: 97-106.
22. Mayhan WG, Faraci FM, Baumbaeh GL, Heistad DD. Effects of aging on response of cerebral arterioles. Am. J. Physiol. 1990; 258: H1138-H1143.
23. Mayhan WG. Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension. Am. J. Physiol. 1990; 259: H1455-H1462.
24. Olesen SP, Crone C. Substances that rapidly augment ionic conductance of endothelium in cerebral venules. Acta Physiol. Scand. 1986; 127: 233-241.
25. Olesen SP. Regulation of ion permeability in frog brain venules, significance of calcium, cyclic nueleotides and protein kinase C. J. Physiol. 1987; 387; 59-08.
26. G-Nitro-L-Arginine (Nolag) on rat pial arterioles in situ. Pflügers Arch. Eur. J. Physiol. 1991; 419 Suppl. 1: R112.
27. Perry DC, Snyder SH. Identification of bradykinin in mammalian brain. J. Neurochem. 1984; 43: 1072-1080.
28. Raymond JJ, Robertson DM, Dinsdale HB. Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier. Can. J. Neurol. Sci. 1986; 13: 214-220.
29. Regoli D, Barabé J. Pharmacology of bradykinin and related kinins. Pharmacol. Rev. 1980; 32: 1-46.
30. Regoli D. Neurohumoral regulation of precapillary vessels: the kallikrein-kinin system. J. Cardiovasc. Pharmacol. 1984; 6 Suppl. 2: S401-S412.
31. Rosenblum WI. Hxdroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles. Circ. Res. 1987; 61: 601-603.
32. Saria A, Lundberg JM, Skofitsch G, Lembeck F, Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge Naunyn-Schmiedeberg's Arch. Pharmacol. 1983; 324: 212-218.
33. Schilling L, Wahl M. Histaminergic effects on cerebral hemodynamics. In: Phillis JW, Ed., The Regulation of Cerebral Blood Flow. Boca Raton: CRC Press, 1993; 113-128.
34. Schürer L, Temesvari P, Wahl M, Unterberg A, Baethmann A. Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone. Acta Neuropathol. 1989; 77: 576-581.
35. Shisheva A, Printz MP, Paul M, Ganten D. Evidence for kinin forming activity in rat brain. Fed. Proc. 1983; 43: 1021.
36. Toda N. Actions of bradykinin on isolated cerebral and peripheral arteries. Am. J. Physiol. 1977; 232: H267-H274.
37. Unterberg A, Baethmann A, Hack U. Cerebral blood flow and metabolism during bradykinin exposure. In: Baldy-Moulinier M, Ingvar DH, Meldrum BS, Eds., Cerebral Blood Flow, Metabolism and Epilepsy. London: John Libbey, 1983: 174-179.
38. Unterberg A, Baethmann A. The kallikrein-kinin system as mediator in vasogenic brain edema, Part 1. Cerebral exposure to bradykinin and plasma. J. Neurosurg. 1984; 61: 87-96.
39. Unterberg A, Wahl M, Baethmann A. Effects of bradykinin on permeability and diameter of pial vessels in vivo. J. Cereb. Blood Flow Metab. 1984; 4: 574-585.
40. Unterberg A, Haek U, Baethmann A. Blood flow, metabolism, and function of the brain during cerebral administration of bradykinin. In: Dietz H, Brock M, Klinger M, Eds., Adv. Neurosurg. Vol. 13. Berlin: Springer. 1985; 326-329.
41. Unterberg A, Dautermann C, Baethmann A, Müller-Esterl W. The kallikrein-kinin system as mediator in vasogenic brain edema, Part 3. Inhibition of the kallikrein-kinin system in traumatic brain swelling. J. Neurosurg. 1986; 64: 269-276.
42. Unterberg A. Veränderungen der Blut-Him-Schrankenfunktion und der zerebralen Vasomotorik durch Mediatoren des sekundären Hirnschadens, Habilitationsschrift, München: 1987.
43. Unterberg A, Wahl M, Hammersen F, Baethmann A. Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. Acta Neuropathol. 1987; 73: 209-219.
44. Unterberg A, Wahl M, Baethmann A. Effects of free radicals on permeability and vasomotor response of cerebral vessels. Acta Neuropathol. 1988; 76: 238-244.
45. Wahl M, Kuschinsky W. The dilatatory action of adenosine on pial arteries of eats and its inhibition by theophylline. Pflügers Arch. 1976; 362: 55-59.
46. 2 receptors. Circ. Res. 1979; 44: 161-165.
47. Wahl M; Young AR, Edvinsson L, Wagner F. Effects of bradykinin on pial arteries and arterioles in vitro and in situ. J. Cereb Blood Flow Metab. 1983a; 3: 231-237.
48. Wahl M, Young AR, Edvinsson L, Wagner F. Effects of kininase II inhibitors on the vasomotor response to bradykinin of feline intracranial and extracranial arteries in vitro and in situ. J. Cereb. Blood Flow Metab. 1983b; 3: 339-345
49. Wahl M. Local chemical, neural, and humoral regulation of cerebrovascular resistance Vessels. J. Cardiovasc. Pharmacol. 1985; 7: S36-S46.
50. Wahl M, Unterberg A, Baethmann A. lntravital fluorescence microscopy for the study of blood-brain-barrier function. Int. J. Microcirc. Clin. Exp. 1985; 4: 3-18.
51. Wahl M, Unterberg A, Whalley ET, Bacthmann A. Young AR, Edvinsson L, Wagner FFW. Effects of bradykinin on cerebral haemodynamics and blood brain barrier function in peptidergic mechanisms. In: Edvinsson L, McCulloch J, Eds., The Cerebral Circulation. Chichester: Horwood. 1987a: 166-190.
52. Wahl M, Lauritzen M, Schilling L. Change of cerebrovascular reactivity after cortical spreading depression in cals and rats. Brain Res. 1987b; 411: 72-80.
53. Wahl M, Unterberg A. Baethmann A. Schilling L. Mediators of hlood-brain barrier dysfunction and formation of vasogenic brain oedema. J. Cereb. Blood Flow Metab. 1988; 8: 621-634.
54. Wahl M, Schilling L, Effects of bradykinin in the cerebral microcirculation. In: Phillis JW, Ed., The Regulation of Blood Flow. Boca Raton: CRC Press, 1993: 315-328.
55. Walter R, Simmons WU, Yoshimoto T. Proline specific endo-and exopeptidases. Molec. Cell. Biochem. 1980; 30: 111-127.
56. Whalley ET, Wahl M. Analysis of bradykinin receptor mediating relaxation of cat cerebral arteries in vivo and in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol. 1983a; 323: 66-71.
57. Whalley ET, Wahl M. The effect of kininase II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin. Pflügers Arch. 1983b; 398: 175-177.
58. Whalley ET, Fritz H, Geiger R. Kinin receptors and angiotensin converting enzyme in rabbits basilar arteries. Naunyn-Schmiedeberg's Arch. Pharmacol. 1983a; 324: 296-301.
59. Whalley ET, Wahl M, Sampaio CAM. Angiotensin-converting enzyme, bradykinin, angiotensin and cerebral vessel reactivity. Hypertension 1983b; 5 Suppl. V: V34-V37.
60. Whalley ET. Metabolism of bradykinin and angiotensin I by human basilar artery and rabbit aorta. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987; 335: 551-554.
61. Whalley ET, Amure YO, Lye RH. Analysis of the mechanism of action of bradykinin on human basilar artery in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987a; 335: 433-437.
62. Whalley ET, Nwator I, Stewart JM, Vavrek RJ. Analysis of the receptor mediating vascular actions of bradykinin. Naunyn-Schmiedehere's Arch. Pharmacol. 1987b; 336: 430-433.
63. Whalley ET, Wahl M. Cerebrovascular reactivity to angiotensin and angiotensin converting enzyme activity in cerebrospinal fluid. Brain Res. 1988; 438: 1-7.
64. Whittle IR, Piper IR, Miller JD. The role of bradykinin in the etiology on vasogenic brain edema and perilesional brain dysfunction. Acta Neurochir. 1992; 115: 53-59.
65. Wiemer G, Popp R, Scholkens BA, Gogelein H. Enhancement of cytosolic calcium, prostacyclin and nitric oxide by bradykinin and the ACE inhibitor ramiprilat in porcine brain capillary endothelial cells. Brain Res. 1994; 638: 261-266.
66. Xu J, Hsu CY, Junker H, Chao S, Hogan EL, Chao J. Kininogen and kinin in experimental spinal cord injury. J. Neurochem. 1991; 57: 975-980.
67. Yang ST, Mayhan WG, Faraci FM, Heistad DD. Mechanism of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats. Stroke 1991; 22: 1177-1 182.