Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension

Brain Research

Volumn 738, Issue 2, 1996, Pages 337-341

  Mayhan, William G ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

brain; cerebral microcirculation; cerebral venules; FITC dextran; Hoe 140; rat; vascular permeability

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; FLUORESCENT DYE; ICATIBANT; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN BLOOD FLOW; CONTROLLED STUDY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ANIMALS; BLOOD-BRAIN BARRIER; BRADYKININ; HYPERTENSION; MALE; PHENYLEPHRINE; RATS; RATS, INBRED WF; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; VENULES;

EID: 0030569314     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01000-1     Document Type: Article

References (24)

1. [1] Butt, A.M., Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anesthetized rats, Brain Res., 696 (1995) 145-150.
2. [2] Edvinsson, L., Johansson, B.B., Larsson, B., MacKenzie, E.T., Skarby, T. and Young, A.R., Calcium antagonists: effects on cerebral blood flow and blood-brain barrier permeability in the rat, Br. J. Pharmacol., 79 (1983) 141-148.
3. [3] Heistad, D.D. and Marcus, M.L., Effect of sympathetic stimulation on permeability of the blood-brain barrier to albumin during acute hypertension in cats, Circ. Res., 45 (1979) 331-338.
4. [4] Heistad, D.D., Marcus, M.L. and Gross, P.M., Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey, Am. J. Physiol., 235 (1978) H544-H552.
5. [5] Hock, F.J., Wirth, K., Albus, U., Linz, W., Gerhards, H.J., Wiemer, G., Henke, St., Breipohl, G., Konig, W., Knolle, J. and Scholkens, B.A., Hoe 140 a new potent and long acting bradykinin antagonist: in vitro studies, Br. J. Pharmacol., 102 (1991) 769-773.
6. [6] Johansson, B.B., Indomethacin and cerebrovascular permeability to albumin in acute hypertension and cerebral embolism in the rat, Exp. Brain Res., 42 (1981) 331-336.
7. [7] Kamitani, T., Little, M.H. and Ellis, E.F., Evidence for a possible role of the brain kallikrein kinin system in the modulation of the cerebral circulation, Circ. Res., 57 (1985) 545-552.
8. [8] MacKenzie, E.T., Strandgaard, S., Graham, D.I., Jones, J.V., Harper, A.M. and Farrar, J.K., Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier, Circ. Res., 39 (1976) 33-41.
9. [9] Maier-Hauff, K., Baethmann, AJ., Lange, M., Schurer, L. and Unterberg, A., The kallikrein-kinin system as mediator of vasogenic brain edema. Part 2. studies on kinin formation in focal and perifocal brain tissue, J. Neurosurg., 61 (1984) 97-106.
10. [10] Mayhan, W.G., Role of nitric oxide in disruption of the blood-brain barrier during acute hypertension, Brain Res., 686 (1995) 99-103.
11. [11] Mayhan, W.G. and Heistad, D.D., Permeability of blood-brain barrier to various sized molecules, Am. J. Physiol., 248 (1985) H712-H718.
12. [12] Mayhan, W.G. and Heistad, D.D., Role of veins and cerebral venous pressure in disruption of the blood-brain barrier, Circ. Res., 59 (1986) 216-220.
13. [13] Mayhan, W.G., Werber, A.H. and Heistad, D.D., Protection of cerebral vessels by sympathetic nerves and vascular hypertrophy, Circulation, 75 (1987) I107-I-112.
14. [14] Nag, S., Protective effect of flunarizine on blood-brain barrier permeability alterations in acutely hypertensive rats, Stroke, 22 (1991) 1265-1269.
15. [15] Olesen, S.P. and Crone, C., Substances that rapidly augment ionic conductance of endothelium in cerebral venules, Acta Physiol. Scand., 127 (1986) 233-241.
16. [16] Reese, T.S. and Karnovsky, MJ., Fine structural localization of a blood-brain barrier to exogenous peroxidase, J. Cell Biol., 34 (1967) 207-217.
17. [17] Sakaki, T., Tsunoda, S. and Morimoto, T., The influence of the calcium antagonist nimodipine and induced hypertension on the behavior of the cerebral pial arteries, the blood-brain barrier, cerebral edema, and cerebral infarction in cats with one-hour occlusion of the middle cerebral artery, Neurosurgery, 28 (1991) 267-272.
18. [18] Unterberg, A., Dautermann, C., Baethmann, A. and Muller-Esterl, W., The kallikrein-kinin system as mediator in vasogenic brain edema, J. Neurosurg., 64 (1986) 269-276.
19. [19] Unterberg, A., Dautermann, C., Muller-Esterl, W. and Baethmann, A., Inhibition of the kallikrein kinin system in vasogenic brain edema, Brain Edema, (1985) 294-298.
20. [20] Unterberg, A., Wahl, M. and Baethmann, A., Bradykinin as mediator in vasogenic brain edema: effects on blood-brain barrier function and pial microcirculation, Adv. Neurotraumatol., 612 (1982) 40-42.
21. [21] Unterberg, A., Wahl, M. and Baethmann, A., Effects of bradykinin on permeability and diameter of pial vessels in vivo, J. Cereb. Blood Flow Metab., 4 (1984) 574-585.
22. [22] Wahl, M., Unterberg, A. and Baethmann, A., Intravital fluorescence microscopy for the study of blood-brain barrier function, Int. J. Microcirc. Clin. Exp., 4 (1985) 3-18.
23. [23] Wahl, M., Unterberg, A., Baethmann, A. and Schilling, L., Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema, J. Cereb. Blood Flow Metab., 8 (1988) 621-634.
24. [24] Zhang, X.M. and Ellis, E.F., Superoxide dismutase reduces permeability and edema induced by hypertension in rats, Am. J. Physiol., 259 (1990) H497-H503.