Intrinsic chemosensitivity: How is it measured; what does it mean; and how does it help us understand the ventilatory response to CO2?

Respiratory Physiology and Neurobiology

Volumn 166, Issue 1, 2009, Pages 13-15

  Leiter, J C ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENOXOLONE; CARBON DIOXIDE; POTASSIUM;

AGE; ARTICLE; CHEMOSENSITIVITY; GAP JUNCTION; HYPERCAPNIA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL; SOLITARY TRACT NUCLEUS; SYNAPTIC INHIBITION;

EID: 62849125240     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2008.12.013     Document Type: Note

References (20)

1. Conrad S.C., Nichols N.L., Ritucci N.A., Dean J.B., and Putnam R.W. Development of chemosensitivity in neurons from the nucleus tractus solitarius (NTS) of neonatal rats. Respir. Physiol. Neurobiol. 166 (2009) 4-12
2. 2 chemoreception and respiratory control. Am. J. Physiol. 283 (2002) L665-L670
3. +-excited neurons in brainstem slices. Respir. Physiol. 129 (2001) 83-100
4. + currents mediate pH-sensitive neuronal activity. Am. J. Physiol. 292 (2007) C292-C304
5. 2 dialysis in the retrotrapezoid nucleus. J. Appl. Physiol. 105 (2008) 83-90
6. Galarreta M., and Hestrin S. Electrical synapses between GABA-releasing interneurons. Nat. Rev. 2 (2001) 425-433
7. Gopnik, A., 2002. The Porcupine. The New Yorker April 1.
8. Guyenet P.G., Stornetta R.L., Bayliss D.A., and Mulkey D.K. Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors. Exp. Physiol. 90 3 (2005) 247-257
9. Hartzler, L.K., Dean, J.B., Putnam, R.W., 2007. Developmental changes in the chemosensitive response in locus coeruleus neurons from neonatal rats. Soc. Neurosci. Abstr. Prog. No. 297.8.
10. Hewitt A., Barrie R., Graham M., Bogus K., Leiter J.C., and Erlichman J.S. Ventilatory effects of gap junctions in the RTN in awake rats. Am. J. Physiol. 287 (2004) R1407-R1418
11. Long M.A., Deans M.R., Paul D.L., and Connors B.W. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J. Neurosci. 22 (2002) 10898-10905
12. Naus C.C.G., and Bani-Yaghoub M. Gap juntional communication in the developing central nervous system. Cell Biol. Intern. 22 (1998) 751-763
13. Parisian K., Wages P., Hewitt A., Leiter J.C., and Erlichman J.S. Ventilatory effects of gap junction blockade in the NTS in awake rats. Respir. Physiol. Neurobiol. 142 (2004) 127-143
14. 2 chemosensitivity. Respir. Physiol. Neurobiol. 149 (2005) 165-179
15. 2 and acid sensing in chemosensitive neurons. Am. J. Physiol. 287 (2004) C1493-C1526
16. 2 of neurons in the rostral ventral medulla in vitro. J. Neurophysiol. 73 (1995) 933-944
17. Richerson G.B., Wang W., Hodges M.R., Dohle C.I., and Diez-Sampedro A. Homing in on the specific phenotype(s) of central respiratory chemoreceptors. Exp. Physiol. 90 3 (2005) 259-269
18. Ritucci N.A., Erlichman J.S., Leiter J.C., and Putnam R.W. Response of membrane potential (Vm) and intracellular pH (pHi) to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus (RTN). Am. J. Physiol. 289 (2005) R851-R861
19. Suzue T. Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat. J. Physiol. 354 (1984) 173-183
20. Vandermaelen C.P., and Aghajanian G.K. Electrophysiological and pharmacological characteristics of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289 (1983) 109-119