Shadows of complexity: What biological networks reveal about epistasis and pleiotropy

BioEssays

Volumn 31, Issue 2, 2009, Pages 220-227

  Tyler, Anna L ^a   Asselbergs, Folkert W ^b   Williams, Scott M ^c   Moore, Jason H ^a,d,e,f,g  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d University of Vermont   (United States)

^e Univ of New Hampshire   (United States)

^f TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^g DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Canalization; Complex disease; Epistasis; Gene gene interactions; Phenotype; Pleiotropy; Scale free network; Systems biology

Indexed keywords

ALPHA CRYSTALLIN; BETA GLOBIN; BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; SONIC HEDGEHOG PROTEIN; SYNTAXIN 1A; TRANSCRIPTION FACTOR EMX1; TRANSCRIPTION FACTOR GLI3; WNT PROTEIN;

ARTICLE; DNA POLYMORPHISM; EPISTASIS; FUNGAL GENETICS; GENE FUNCTION; GENE INTERACTION; GENE MUTATION; HUMAN; PALLISTER HALL SYNDROME; PHENOTYPE; PLEIOTROPY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYSTEMS BIOLOGY; GENE REGULATORY NETWORK; GENETIC EPISTASIS;

EPISTASIS, GENETIC; GENE REGULATORY NETWORKS; HUMANS; PHENOTYPE;

EID: 62849096643     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.200800022     Document Type: Article

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