Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Meng, Yuanguang ^a   Gu, Chenglei ^a   Wu, Zhiqiang ^a   Zhao, Yali ^a   Si, Yiling ^a   Fu, Xiaobing ^a   Han, Weidong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; INHIBITOR OF DIFFERENTIATION 2; MESSENGER RNA; MUTANT PROTEIN; UVOMORULIN; CADHERIN; ESTROGEN RECEPTOR ALPHA; HELIX LOOP HELIX PROTEIN; ID2 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CELL ACTIVITY; CELL GROWTH; CELL INVASION; CELL MOTILITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DIMERIZATION; GENE ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; BIOSYNTHESIS; BREAST TUMOR; CANCER INVASION; CELL MOTION; DRUG ANTAGONISM; FEMALE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; OVARY TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CADHERINS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; DIMERIZATION; ESTROGEN RECEPTOR ALPHA; FEMALE; HELIX-LOOP-HELIX MOTIFS; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 2; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 62749148350     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-75     Document Type: Article

References (37)

1. Sahai E Mechanisms of cancer cell invasion Curr Opin Genet Dev 2005, 15:87-96. 10.1016/j.gde.2004.12.002 15661538
2. Sahai E Immuminating the metastasis process Nat Rev Cancer 2007, 7:737-749. 10.1038/nrc2229 17891189
3. Welch DR Steeg PS Rinker-Schaeffer CW Molecular biology of breast cancer metastasis Genetic regulation of human breast carcinoma metastasis Breast Cancer Res 2000, 2:406-418. 10.1186/bcr87
4. Meng Q Qi M Chen DZ Yuan R Goldberg ID Rosen EM Auborn K Fan S Suppression of breast cancer invasion and migration by indole-3-carbinol: Associated with up-regulation of BRCA1 and E-cadherin/ catenin complexes J Mol Med 2000, 78:155-165. 10.1007/s001090000088 10868478
5. Sood AK Bhatty R Kamat AA Landen CN Han L Thaker PH Li Y Gershenson DM Lutgendorf S Cole SW Stress hormone-mediated invasion of ovarian cancer cells Clin Cancer Res 2006, 12:369-375. 10.1158/1078-0432.CCR-05-1698 16428474
6. Yuecheng Y Hongmeng L Xiaoyan L Clinical evaluation of E-cadherin expression andits regulation mechanism in epithelial ovarian cancer Clin Exp Metastasis 2006, 23:65-74. 10.1007/s10585-006-9020-3 16826427
7. Ya mashita T Tazawa S Yawei Z Katayama H Kato Y Nishiwaki K Yokohama Y Ishikawa M Suppression of invasive characteristics by antisense introduction of overexpressed HOX genes in ovarian cancer cells Int J Oncol 2006, 28:931-938. 16525643
8. Meng YG Han WD Zhao YL Huang K Si YL Wu ZQ Mu YM Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin Cell Res 2007, 17:869-880. 10.1038/cr.2007.79 17893710
9. Norton JD Deed RW Craggs G Sablitzky F Id helix-loop-helix proteins in cell growth and differentiation Trends Cell Biol 1998, 8:58-65. 10.1016/ S0962-8924(97)01183-5 9695810
10. Yokota Y Id and development Oncogene 2001, 20:8290-8298. 10.1038/ sj.onc.1205090 11840321
11. Massari ME Murre C Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms Mol Cell Biol 2000, 20:429-440. 85097 10611221 10.1128/MCB.20.2.429-440.2000
12. Perk J Iavarone A Benezra R Id family of helix-loop-helix proteins in cancer Nat Rev Cancer 2005, 5:603-614. 10.1038/nrc1673 16034366
13. Fong S Debs RJ Desprez PY Id genes and proteins as promising targets in cancer therapy Trends Mol Med 2004, 10:387-392. 10.1016/ j.molmed.2004.06.008 15310459
14. Norton JD ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis J Cell Sci 2000, 113:3897-3905. 11058077
15. Iavarone A Lasorella A Id proteins as targets in cancer and tools in neurobiology Trends Mol Med 2006, 12:588-594. 10.1016/ j.molmed.2006.10.007 17071138
16. Desprez PY Sumida T Coppé JP Helix-loop-helix proteins in mammary gland development and breast cancer J Mammary Gland Biol Neoplasia 2003, 8:225-239. 10.1023/A:1025957025773 14635797
17. Benezra R Davis RL Lockshon D Turner DL Weintraub H The protein Id: A negative regulator of helix-loop-helix DNA binding proteins Cell 1990, 61:49-59. 10.1016/0092-8674(90)90214-Y 2156629
18. Roberts EC Deed RW Inoue T Norton JD Sharrocks AD Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding Mol Cell Biol 2001, 21:524-533. 86614 11134340 10.1128/ MCB.21.2.524-533.2001
19. Yates PR Atherton GT Deed RW Norton JD Sharrocks AD Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors EMBO J 1999, 18:968-976. 1171189 10022839 10.1093/ emboj/18.4.968
20. Lasorella A Boldrini R Dominici C Donfrancesco A Yokota Y Inserra A Iavarone A Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins Nature 2000, 407:592-598. 10.1038/ 35036504 11034201
21. Florio M Hernandez M-C Yang H Shu H-K Cleveland JL Israel MA Id2 promotes apoptosis by a novel mechanism independent of domerization to basic helix-loop-helix factors Mol Cell Biol 1998, 18:5435-5444. 109128 9710627
22. Lasorella A Stegmüller J Guardavaccaro D Liu G Carro MS Rothschild G de la Torre-Ubieta L Pagano M Bonnis A Iavarone A Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth Nature 2006, 442:471-474. 10.1038/nature04895 16810178
23. Itahana Y Singh J Sumida T Coppé JP Parrinello S Bennington JL Desprez PY Role of Id2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells Cancer Res 2003, 63:7098-7105. 14612502
24. Kowanetz M Valcourt U Bergström R Heldin CH Moustakas A Is2 and Id3 defines the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein Mol Cell Biol 2004, 24:4241-4254. 400464 15121845 10.1128/ MCB.24.10.4241-4254.2004
25. Hendrix MJ Seftor EA Seftor ER Fidler IJ A simple quantitative assay for studying the invasive potential of high and low human metastatic variants Cancer Lett 1987, 38:137-147. 10.1016/0304-3835(87)90209-6 3690504
26. Christofori G Semb H The role of the cell-adhesion molecule Ecadherin as a tumour-suppressor gene Trends Biochem Sci 1999, 24:73-76. 10.1016/ S0968-0004(98)01343-7 10098402
27. Howard EW Camm KD Wong YC Wang XH E-cadherin up-regulation as a therapeutic goal in cancer treatment Mini Rev Med Chem 2008, 8:496-518. 10.2174/138955708784223521 18473938
28. McLemore MR Miaskowski C Aouizerat BE Chen LM Dodd M Rules of tumor cell development and their application to biomarkers for ovarian cancer Oncol Nurs Forum 2008, 35:403-409. 10.1188/08.ONF.403-409 18467290
29. Giancotti V Breast cancer markers Cancer Lett 2006, 243:145-159. 10.1016/ j.canlet.2006.01.035 16530325
30. Batlle E Sancho E Franci C Dominguez D Monfar M Baulida J de Herreros AG The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nat Cell Biol 2000, 2:84-89. 10.1038/35000034 10655587
31. Yang J Mani SA Donaher JL Ramaswamy S Itzykson RA Come C Savarner P Gitelman I Richardson P Weinberg RA Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 2004, 117:927-939. 10.1016/j.cell.2004.06.006 15210113
32. Oesterreich S Deng W Jiang S Cui X Ivanova M Schiff R Kang K Hadsell DL Behrens J Lee AV Estrogen-mediated downregulation of E-cadherin in breast cancer cells Cancer Res 2003, 63:5203-5208. 14500345
33. Onken MD Ehler JP Worley LA Makita J Yokota Y Harbour JW Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas Cancer Res 2006, 66:4602-4609. 10.1158/0008-5472.CAN-05-4196 16651410
34. Coppe JP Itahana Y Moore DH Bennington JL Desprez PY Id-1 and Id-2 as molecular markers for human prostate cancer pregression Clin Cancer Res 2004, 10:2044-2051. 10.1158/1078-0432.CCR-03-0933 15041724
35. Stighall M Manetopoulos C Axelson H Landberg G High Id2 protein expression correlates with a favorable prognosis in patients with primary breast cancer nd reduces cellular invasiveness of breast cancer cells Int J Cancer 2005, 115:403-411. 10.1002/ijc.20875 15688367
36. Kondo M Cubillo E Tobiume K Shirakihara T Fukuda N Suzuki H Shimizu K Takehara K Cano A Saitoh M Miyazono K A role for Id in the regulation of TGF-beta-induced epithelialmesenchymal transdifferentiation Cell Death Differ 2004, 11:1092-101. 10.1038/sj.cdd.4401467 15181457
37. Perez-Moreno MA Locascio A Rodrigo I Dhondt D Portillo F Nieto MA Cano A A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions J Biol Chem 2001, 276:27424-27431. 10.1074/jbc.M100827200 11309385