Aminoglycoside antibiotics restore functional expression of truncated HERG channels produced by nonsense mutations

Heart Rhythm

Volumn 6, Issue 4, 2009, Pages 553-560

  Yao, Yan ^a   Teng, Siyong ^a   Li, Ning ^a   Zhang, Yinhui ^a   Boyden, Penelope A ^b   Pu, Jielin ^a  

^a FUWAI HOSPITAL   (China)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Aminoglycoside antibiotics; HERG; Long QT syndrome; Nonsense mutation

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC G 418; GENTAMICIN; POTASSIUM CHANNEL HERG;

ARTICLE; CELL CULTURE; CELL DENSITY; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMAGING; IN VITRO STUDY; INTERVENTION STUDY; MUTANT; NONSENSE MUTATION; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; WHOLE CELL; WILD TYPE;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELLS, CULTURED; CODON, NONSENSE; ETHER-A-GO-GO POTASSIUM CHANNELS; GENTAMICINS; HUMANS; LONG QT SYNDROME; MICROSCOPY, CONFOCAL; PATCH-CLAMP TECHNIQUES; TRANSFECTION;

EID: 62749148294     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.01.017     Document Type: Article

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