메뉴 건너뛰기




Volumn 42, Issue 1, 2009, Pages 87-93

New nitric oxide donors based on ruthenium complexes

Author keywords

Nitric oxide donor; Nitrovasodilator; Ruthenium complex; Vasodilatation

Indexed keywords

CALCIUM ION; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; NITRIC OXIDE; NITRIC OXIDE DONOR; OXYGEN; POTASSIUM CHANNEL; RUTHENIUM COMPLEX; SUPEROXIDE;

EID: 62749120081     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2009000100013     Document Type: Conference Paper
Times cited : (41)

References (50)
  • 1
    • 0032707717 scopus 로고    scopus 로고
    • Nitric oxide as a signaling molecule in the vascular system: An overview
    • Ignarro LJ, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 1999; 34: 879-886.
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 879-886
    • Ignarro, L.J.1    Cirino, G.2    Casini, A.3    Napoli, C.4
  • 2
    • 0018311634 scopus 로고
    • Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine
    • Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro L. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res 1979; 5: 211-224.
    • (1979) J Cyclic Nucleotide Res , vol.5 , pp. 211-224
    • Gruetter, C.A.1    Barry, B.K.2    McNamara, D.B.3    Gruetter, D.Y.4    Kadowitz, P.J.5    Ignarro, L.6
  • 3
    • 0038643251 scopus 로고    scopus 로고
    • Nitroxyl gets to the heart of the matter
    • Feelisch M. Nitroxyl gets to the heart of the matter. Proc Natl Acad Sci U S A 2003; 100: 4978-4980.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4978-4980
    • Feelisch, M.1
  • 4
    • 0037884933 scopus 로고    scopus 로고
    • Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from betaadrenergic signaling
    • Paolocci N, Katori T, Champion HC, St John M, Miranda KM, Fukuto JM, et al. Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from betaadrenergic signaling. Proc Natl Acad Sci U S A 2003; 100: 5537-5542.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5537-5542
    • Paolocci, N.1    Katori, T.2    Champion, H.C.3    St John, M.4    Miranda, K.M.5    Fukuto, J.M.6
  • 5
    • 0037059510 scopus 로고    scopus 로고
    • Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview
    • Ignarro LJ, Napoli C, Loscalzo J. Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circ Res 2002; 90: 21-28.
    • (2002) Circ Res , vol.90 , pp. 21-28
    • Ignarro, L.J.1    Napoli, C.2    Loscalzo, J.3
  • 6
    • 42749088177 scopus 로고    scopus 로고
    • A novel mechanism of vascular relaxation induced by sodium nitroprusside in the isolated rat aorta
    • Bonaventura D, Lunardi CN, Rodrigues GJ, Neto MA, Bendhack LM. A novel mechanism of vascular relaxation induced by sodium nitroprusside in the isolated rat aorta. Nitric Oxide 2008; 18: 287-295.
    • (2008) Nitric Oxide , vol.18 , pp. 287-295
    • Bonaventura, D.1    Lunardi, C.N.2    Rodrigues, G.J.3    Neto, M.A.4    Bendhack, L.M.5
  • 7
    • 33749040489 scopus 로고    scopus 로고
    • Cytosolic calcium concentration is reduced by photolysis of a nitrosyl ruthenium complex in vascular smooth muscle cells
    • Lunardi CN, Cacciari AL, Silva RS, Bendhack LM. Cytosolic calcium concentration is reduced by photolysis of a nitrosyl ruthenium complex in vascular smooth muscle cells. Nitric Oxide 2006; 15: 252-258.
    • (2006) Nitric Oxide , vol.15 , pp. 252-258
    • Lunardi, C.N.1    Cacciari, A.L.2    Silva, R.S.3    Bendhack, L.M.4
  • 8
    • 0033988845 scopus 로고    scopus 로고
    • Vasodilator effects of organotransition-metal nitrosyl complexes, novel nitric oxide donors
    • Wang YX, Legzdins P, Poon JS, Pang CC. Vasodilator effects of organotransition-metal nitrosyl complexes, novel nitric oxide donors. J Cardiovasc Pharmacol 2000; 35: 73-77.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 73-77
    • Wang, Y.X.1    Legzdins, P.2    Poon, J.S.3    Pang, C.C.4
  • 9
    • 0037177476 scopus 로고    scopus 로고
    • In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressure
    • Marcondes FG, Ferro AA, Souza-Torsoni A, Sumitani M, Clarke MJ, Franco DW, et al. In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressure. Life Sci 2002; 70: 2735-2752.
    • (2002) Life Sci , vol.70 , pp. 2735-2752
    • Marcondes, F.G.1    Ferro, A.A.2    Souza-Torsoni, A.3    Sumitani, M.4    Clarke, M.J.5    Franco, D.W.6
  • 10
    • 0030776954 scopus 로고    scopus 로고
    • Ruthenium complexes as nitric oxide scavengers: A potential therapeutic approach to nitric oxidemediated diseases
    • Fricker SP, Slade E, Powell NA, Vaughan OJ, Henderson GR, Murrer BA, et al. Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxidemediated diseases. Br J Pharmacol 1997; 122: 1441-1449.
    • (1997) Br J Pharmacol , vol.122 , pp. 1441-1449
    • Fricker, S.P.1    Slade, E.2    Powell, N.A.3    Vaughan, O.J.4    Henderson, G.R.5    Murrer, B.A.6
  • 11
    • 0002720222 scopus 로고    scopus 로고
    • Kinetics of nitric oxide scavenging by ruthenium(III) polyaminocarboxylates: Novel therapeutic agents for septic shock
    • Davies NA, Wilson MT, Slade E, Fricker SP, Murrer BA, Powell NA, et al. Kinetics of nitric oxide scavenging by ruthenium(III) polyaminocarboxylates: Novel therapeutic agents for septic shock. Chem Commun 1997; 47-48.
    • (1997) Chem Commun , pp. 47-48
    • Davies, N.A.1    Wilson, M.T.2    Slade, E.3    Fricker, S.P.4    Murrer, B.A.5    Powell, N.A.6
  • 12
    • 0033815582 scopus 로고    scopus 로고
    • Photoreactions of coordinated nitrite ion. Reversible nitric oxide labilization from the chromium(III) complex [trans-Cr(cyclam)(ONO)2]+
    • DeLeo MA, Ford PC. Photoreactions of coordinated nitrite ion. Reversible nitric oxide labilization from the chromium(III) complex [trans-Cr(cyclam)(ONO)2]+. Coord Chem Rev 2000; 208: 47-59.
    • (2000) Coord Chem Rev , vol.208 , pp. 47-59
    • DeLeo, M.A.1    Ford, P.C.2
  • 13
    • 0033802211 scopus 로고    scopus 로고
    • Flash and continuous photolysis studies of Roussin's red salt dianion Fe2S2(NO)4/2- in solution
    • Bourassa JL, Ford PC. Flash and continuous photolysis studies of Roussin's red salt dianion Fe2S2(NO)4/2- in solution. Coord Chem Rev 2000; 200-202: 887-900.
    • (2000) Coord Chem Rev
    • Bourassa, J.L.1    Ford, P.C.2
  • 14
    • 0034625887 scopus 로고    scopus 로고
    • Photoreactivity of the ruthenium nitrosyl complex, Ru(salen)(Cl)(NO). Solvent effects on the back reaction of NO with the Lewis acid Ru(III)(salen)(Cl) [1]
    • Ford PC, Ford PC. Photoreactivity of the ruthenium nitrosyl complex, Ru(salen)(Cl)(NO). Solvent effects on the back reaction of NO with the Lewis acid Ru(III)(salen)(Cl) [1]. J Am Chem Soc 2000; 122: 7592-7593.
    • (2000) J Am Chem Soc , vol.122 , pp. 7592-7593
    • Ford, P.C.1    Ford, P.C.2
  • 15
    • 0034732530 scopus 로고    scopus 로고
    • DeLeo MA, Bu X, Bentow J, Ford PC. The synthesis, characterization and structures of the chromium(III) dinitrito complexes: trans-[Cr(L)(ONO)2]+ (L = 1,4,8,11-tetraazacyclotetradecane or 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane). Inorganica Chim Acta 2000; 300-302: 944-950.
    • DeLeo MA, Bu X, Bentow J, Ford PC. The synthesis, characterization and structures of the chromium(III) dinitrito complexes: trans-[Cr(L)(ONO)2]+ (L = 1,4,8,11-tetraazacyclotetradecane or 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane). Inorganica Chim Acta 2000; 300-302: 944-950.
  • 16
    • 0001538498 scopus 로고    scopus 로고
    • Flash photolysis studies of Roussin's black salt anion: Fe(4)S(3)(NO)(7)(-)
    • Bourassa J, Lee B, Bernard S, Schoonover J, Ford PC. Flash photolysis studies of Roussin's black salt anion: Fe(4)S(3)(NO)(7)(-). Inorg Chem 1999; 38: 2947-2952.
    • (1999) Inorg Chem , vol.38 , pp. 2947-2952
    • Bourassa, J.1    Lee, B.2    Bernard, S.3    Schoonover, J.4    Ford, P.C.5
  • 17
    • 0037264316 scopus 로고    scopus 로고
    • Structure, chemical and photochemical reactivity and biological activity of some ruthenium amine nitrosyl complexes
    • Tfouni E, Krieger M, McGarvey BR, Franco DW. Structure, chemical and photochemical reactivity and biological activity of some ruthenium amine nitrosyl complexes. Coord Chem Rev 2003; 236: 57-69.
    • (2003) Coord Chem Rev , vol.236 , pp. 57-69
    • Tfouni, E.1    Krieger, M.2    McGarvey, B.R.3    Franco, D.W.4
  • 18
    • 0027253654 scopus 로고
    • Autoxidation kinetics of aqueous nitric oxide
    • Ford PC, Wink DA, Stanbury DM. Autoxidation kinetics of aqueous nitric oxide. FEBS Lett 1993; 326: 1-3.
    • (1993) FEBS Lett , vol.326 , pp. 1-3
    • Ford, P.C.1    Wink, D.A.2    Stanbury, D.M.3
  • 20
    • 0029816853 scopus 로고    scopus 로고
    • Direct and indirect effects of nitric oxide in chemical reactions relevant to biology
    • Wink DA, Grisham MB, Mitchell JB, Ford PC. Direct and indirect effects of nitric oxide in chemical reactions relevant to biology. Methods Enzymol 1996; 268: 12-31.
    • (1996) Methods Enzymol , vol.268 , pp. 12-31
    • Wink, D.A.1    Grisham, M.B.2    Mitchell, J.B.3    Ford, P.C.4
  • 21
    • 28844440472 scopus 로고    scopus 로고
    • The ruthenium-based nitric oxide scavenger, AMD6221, augments cardiovascular responsiveness to noradrenaline in rats with streptozotocin-induced diabetes
    • Hutchings SR, Song D, Fricker SP, Pang CC. The ruthenium-based nitric oxide scavenger, AMD6221, augments cardiovascular responsiveness to noradrenaline in rats with streptozotocin-induced diabetes. Eur J Pharmacol 2005; 528: 132-136.
    • (2005) Eur J Pharmacol , vol.528 , pp. 132-136
    • Hutchings, S.R.1    Song, D.2    Fricker, S.P.3    Pang, C.C.4
  • 23
    • 0026758657 scopus 로고
    • Receptor guanylyl cyclases
    • Wong SK, Garbers DL. Receptor guanylyl cyclases. J Clin Invest 1992; 90: 299-305.
    • (1992) J Clin Invest , vol.90 , pp. 299-305
    • Wong, S.K.1    Garbers, D.L.2
  • 24
    • 0032902722 scopus 로고    scopus 로고
    • Guanylate cyclase and the. NO/cGMP signaling pathway
    • Denninger JW, Marletta MA. Guanylate cyclase and the. NO/cGMP signaling pathway. Biochim Biophys Acta 1999; 1411: 334-350.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 334-350
    • Denninger, J.W.1    Marletta, M.A.2
  • 25
  • 26
    • 0021750364 scopus 로고
    • Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP
    • Aitken A, Hemmings BA, Hofmann F. Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP. Biochim Biophys Acta 1984; 790: 219-225.
    • (1984) Biochim Biophys Acta , vol.790 , pp. 219-225
    • Aitken, A.1    Hemmings, B.A.2    Hofmann, F.3
  • 27
    • 0032486387 scopus 로고    scopus 로고
    • Activation by autophosphorylation or cGMP binding produces a similar apparent conformational change in cGMP-dependent protein kinase
    • Chu DM, Francis SH, Thomas JW, Maksymovitch EA, Fosler M, Corbin JD. Activation by autophosphorylation or cGMP binding produces a similar apparent conformational change in cGMP-dependent protein kinase. J Biol Chem 1998; 273: 14649-14656.
    • (1998) J Biol Chem , vol.273 , pp. 14649-14656
    • Chu, D.M.1    Francis, S.H.2    Thomas, J.W.3    Maksymovitch, E.A.4    Fosler, M.5    Corbin, J.D.6
  • 29
    • 0034862256 scopus 로고    scopus 로고
    • Invited review: CGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression
    • Lincoln TM, Dey N, Sellak H. Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 2001; 91: 1421-1430.
    • (2001) J Appl Physiol , vol.91 , pp. 1421-1430
    • Lincoln, T.M.1    Dey, N.2    Sellak, H.3
  • 30
    • 0036768296 scopus 로고    scopus 로고
    • Nitric oxide induces hyperpolarization by opening ATP-sensitive K(+) channels in guinea pig spiral modiolar artery
    • Si JQ, Zhao H, Yang Y, Jiang ZG, Nuttall AL. Nitric oxide induces hyperpolarization by opening ATP-sensitive K(+) channels in guinea pig spiral modiolar artery. Hear Res 2002; 171: 167-176.
    • (2002) Hear Res , vol.171 , pp. 167-176
    • Si, J.Q.1    Zhao, H.2    Yang, Y.3    Jiang, Z.G.4    Nuttall, A.L.5
  • 31
    • 0029095574 scopus 로고
    • Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues
    • Kuriyama H, Kitamura K, Nabata H. Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev 1995; 47: 387-573.
    • (1995) Pharmacol Rev , vol.47 , pp. 387-573
    • Kuriyama, H.1    Kitamura, K.2    Nabata, H.3
  • 32
    • 0025094699 scopus 로고
    • Structure-activity relationships of K+ channel openers
    • Edwards G, Weston AH. Structure-activity relationships of K+ channel openers. Trends Pharmacol Sci 1990; 11: 417-422.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 417-422
    • Edwards, G.1    Weston, A.H.2
  • 34
    • 0029108913 scopus 로고
    • Physiological roles and properties of potassium channels in arterial smooth muscle
    • Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268: C799-C822.
    • (1995) Am J Physiol , vol.268
    • Nelson, M.T.1    Quayle, J.M.2
  • 35
    • 20344365857 scopus 로고    scopus 로고
    • Decreased vasodilation induced by a new nitric oxide donor in two kidney, one clip hypertensive rats is due to impaired K channel activation
    • Bonaventura D, Oliveira FS, da Silva RS, Bendhack LM. Decreased vasodilation induced by a new nitric oxide donor in two kidney, one clip hypertensive rats is due to impaired K channel activation. Clin Exp Pharmacol Physiol 2005; 32: 478-481.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 478-481
    • Bonaventura, D.1    Oliveira, F.S.2    da Silva, R.S.3    Bendhack, L.M.4
  • 36
    • 2342613478 scopus 로고    scopus 로고
    • Bonaventura D, de S Oliveira, Togniolo V, Tedesco AC, da Silva RS, Bendhack LM. A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation. Nitric Oxide 2004; 10: 83-91.
    • Bonaventura D, de S Oliveira, Togniolo V, Tedesco AC, da Silva RS, Bendhack LM. A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation. Nitric Oxide 2004; 10: 83-91.
  • 37
    • 33846192014 scopus 로고    scopus 로고
    • Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: Sodium nitroprusside and a new ruthenium complex
    • Bonaventura D, de Lima RG, Vercesi JA, da Silva RS, Bendhack LM. Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex. Vascul Pharmacol 2007; 46: 215-222.
    • (2007) Vascul Pharmacol , vol.46 , pp. 215-222
    • Bonaventura, D.1    de Lima, R.G.2    Vercesi, J.A.3    da Silva, R.S.4    Bendhack, L.M.5
  • 38
    • 33646077685 scopus 로고    scopus 로고
    • Influence of ancillary ligand L in the nitric oxide photorelease by the [Ru(L)(tpy)NO](3+) complex and its vasodilator activity based on visible light irradiation
    • de Lima RG, Sauaia MG, Bonaventura D, Tedesco AC, Bendhack LM, da Silva R. Influence of ancillary ligand L in the nitric oxide photorelease by the [Ru(L)(tpy)NO](3+) complex and its vasodilator activity based on visible light irradiation. Inorganica Chim Acta 2006; 359: 2543-2549.
    • (2006) Inorganica Chim Acta , vol.359 , pp. 2543-2549
    • de Lima, R.G.1    Sauaia, M.G.2    Bonaventura, D.3    Tedesco, A.C.4    Bendhack, L.M.5    da Silva, R.6
  • 39
    • 34447628640 scopus 로고    scopus 로고
    • Vasorelaxation induced by the new nitric oxide donor cis-[Ru(Cl) (bpy)(2)(NO)](PF(6)) is due to activation of K(Ca) by a cGMP-dependent pathway
    • Lunardi CN, Vercesi JA, da Silva RS, Bendhack LM. Vasorelaxation induced by the new nitric oxide donor cis-[Ru(Cl) (bpy)(2)(NO)](PF(6)) is due to activation of K(Ca) by a cGMP-dependent pathway. Vascul Pharmacol 2007; 47: 139-144.
    • (2007) Vascul Pharmacol , vol.47 , pp. 139-144
    • Lunardi, C.N.1    Vercesi, J.A.2    da Silva, R.S.3    Bendhack, L.M.4
  • 42
    • 3242666332 scopus 로고    scopus 로고
    • Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMPindependent decrease in calcium sensitivity of myofilaments
    • Soloviev A, Lehen'kyi V, Zelensky S, Hellstrand P. Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMPindependent decrease in calcium sensitivity of myofilaments. Cell Calcium 2004; 36: 165-173.
    • (2004) Cell Calcium , vol.36 , pp. 165-173
    • Soloviev, A.1    Lehen'kyi, V.2    Zelensky, S.3    Hellstrand, P.4
  • 43
    • 0033015343 scopus 로고    scopus 로고
    • 2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism
    • 2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J Neurophysiol 1999; 81: 1449-1457.
    • (1999) J Neurophysiol , vol.81 , pp. 1449-1457
    • Summers, B.A.1    Overholt, J.L.2    Prabhakar, N.R.3
  • 44
    • 0027935877 scopus 로고
    • Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase
    • Archer SL, Huang JM, Hampl V, Nelson DP, Shultz PJ, Weir EK. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A 1994; 91: 7583-7587.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7583-7587
    • Archer, S.L.1    Huang, J.M.2    Hampl, V.3    Nelson, D.P.4    Shultz, P.J.5    Weir, E.K.6
  • 45
    • 0028220671 scopus 로고
    • Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
    • Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994; 368: 850-853.
    • (1994) Nature , vol.368 , pp. 850-853
    • Bolotina, V.M.1    Najibi, S.2    Palacino, J.J.3    Pagano, P.J.4    Cohen, R.A.5
  • 46
    • 33750429908 scopus 로고    scopus 로고
    • Characterization of the mechanisms of action and nitric oxide species involved in the relaxation induced by the ruthenium complex
    • Bonaventura D, Oliveira FS, Lunardi CN, Vercesi JA, da Silva RS, Bendhack LM. Characterization of the mechanisms of action and nitric oxide species involved in the relaxation induced by the ruthenium complex. Nitric Oxide 2006; 15: 387-394.
    • (2006) Nitric Oxide , vol.15 , pp. 387-394
    • Bonaventura, D.1    Oliveira, F.S.2    Lunardi, C.N.3    Vercesi, J.A.4    da Silva, R.S.5    Bendhack, L.M.6
  • 48
    • 36348972996 scopus 로고    scopus 로고
    • Caveolae dysfunction contributes to impaired relaxation induced by nitric oxide donor in aorta from renal hypertensive rats
    • Rodrigues GJ, Restini CB, Lunardi CN, Moreira JE, Lima RG, da Silva RS, et al. Caveolae dysfunction contributes to impaired relaxation induced by nitric oxide donor in aorta from renal hypertensive rats. J Pharmacol Exp Ther 2007; 323: 831-837.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 831-837
    • Rodrigues, G.J.1    Restini, C.B.2    Lunardi, C.N.3    Moreira, J.E.4    Lima, R.G.5    da Silva, R.S.6
  • 49
    • 41149101535 scopus 로고    scopus 로고
    • Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats
    • Rodrigues GJ, Lunardi CN, Lima RG, Santos CX, Laurindo FR, da Silva RS, et al. Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats. Nitric Oxide 2008; 18: 176-183.
    • (2008) Nitric Oxide , vol.18 , pp. 176-183
    • Rodrigues, G.J.1    Lunardi, C.N.2    Lima, R.G.3    Santos, C.X.4    Laurindo, F.R.5    da Silva, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.