Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 1893-1899

  Queiroz, Maria João R P ^a   Calhelha, Ricardo C ^a   Vale Silva, Luís A ^b   Pinto, Eugénia ^b   Sao Jose Nascimento M ^b  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antitumor activity; Benzo b thiophenes; Benzothieno 2,3 c pyran 1 ones; Intramolecular lactonization; Sonogashira coupling

Indexed keywords

3 (2 FLUOROPHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 3 (4 FLUOROPHENYL) 7 METHOXYBENZOTHIENO[2,3 C]PYRAN 1 ONE; 3 (4 FLUOROPHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 3 (4 METHOXYPHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 3 (PHENYL) 7 METHOXYBENZOTHIENO[2,3 C]PYRAN 1 ONE; 3 (PHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 4 IODO 3 (2 FLUOROPHENYL) 7 METHOXYBENZOTHIENO[2,3 C]PYRAN 1 ONE; 4 IODO 3 (4 FLUOROPHENYL) 7 METHOXYBENZOTHIENO[2,3 C]PYRAN 1 ONE; 4 IODO 3 (4 FLUOROPHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 4 IODO 3 (4 METHOXYPHENYL)BENZOTHIENO[2,3 C]PYRAN 1 ONE; 4 IODO 3 (PHENYL) 7 METHOXYBENZOTHIENO[2,3 C]PYRAN 1 ONE; IODINE; LACTONE DERIVATIVE; METHYL 3 (PHENYLETHYNYL)BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 3 [(2 FLUOROPHENYL)ETHYNYL]BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 3 [(4 FLUOROPHENYL)ETHYNYL]BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 3 [(4 METHOXYPHENYL)ETHYNYL] BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 3 BROMO 6 METHOXYBENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 3 BROMOBENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 6 METHOXY 3 (PHENYLETHYNYL)BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 6 METHOXY 3 [(2 FUOROPHENYL)ETHYNYL]BENZO[B]THIOPHENE 2 CARBOXYLATE; METHYL 6 METHOXY 3 [(4 FUOROPHENYL)ETHYNYL]BENZO[B]THIOPHENE 2 CARBOXYLATE; PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER GROWTH; CANCER INHIBITION; CELL STRAIN; CENTRAL NERVOUS SYSTEM TUMOR; CYCLIZATION; DRUG DETERMINATION; DRUG INHIBITION; DRUG SCREENING; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; ONE POT SYNTHESIS; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CYCLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PYRANS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 62749114726     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.11.002     Document Type: Article

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