A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells

Cancer Chemotherapy and Pharmacology

Volumn 59, Issue 3, 2007, Pages 329-335

  Kawano, Takeshi ^a   Agata, Naoki ^a   Kharbanda, Surender ^a   Avigan, David ^a   Kufe, Donald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Isocoumarins; Mitotic arrest; Multiple myeloma; NM 3 analog

Indexed keywords

2 (8 HYDROXY 6 METHOXY 1 OXO 1H 2 BENZOPYRAN 3 YL)PROPIONIC ACID; 8 METHOXY 6 METHYL 3 (3 PYRIDYLMETHYL)ISOCOUMARIN; ISOCOUMARIN DERIVATIVE; PACLITAXEL; PROTEIN BCL 2; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MITOSIS; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANTIMITOTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; ISOCOUMARINS; MICROTUBULES; MITOSIS; MULTIPLE MYELOMA;

EID: 33845897910     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0274-x     Document Type: Article

References (17)

1. Soulie P, Gamelin E, Eder J (2003) A dose finding study of an oral antiangiogenesis inhibitor, NM-3 safety profile and effects on surrogate markers with once-daily dosing. Abstract No. 777. Proc Amer Soc Clin Oncol
2. Bonate P, Eder J, Soulie P (2003) Pharmacokinetics of a new antiangiogenic isocoumarin derivative, NM-3 in two oral once a day-dose schedules with escalating doses, Abstract No. 537. Proc Amer Soc Clin Oncol 22:132
3. Nakashima T, Hirano S, Agata N et al (1999) Inhibition of angiogenesis by a new isocoumarin, NM-3. J Antibiot 52:426-428
4. Salloum R, Jaskowiak N, Mauceri H et al (2000) NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res 60:6958-6963
5. Agata N, Tsuchiya A, Issihiki K (2001) NM-3, a novel orally bioavilable antiangeiogenic agents suppresses hypoxia-induced vascular endothelial growth factor (VEGF) in human fibroblasts and tumor cells. Proc AACR 41:587
6. Yin L, Ohno T, Weichselbaum R et al (2001) The novel isocoumarin NM-3 induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther 1:43-48
7. Agata N, Nogi H, Milhollen M et al (2004) NM-3, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells. Cancer Res 64:8512-8516
8. Agata N, Nogi H, Bamberg M et al (2005) The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol 56:610-614
9. Zhu JS, Shen B, Chen JL et al (2003) Molecule action mechanisms of NM-3 on human gastric cancer SGC-7901 cells in vivo or in vitro. World J Gastroenterol 9:2366-2369
10. Reimer C, Agata N, Tammam J et al (2002) Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res 62:789-795
11. Nguyen L, Guyon-Gellin Y, Phan H et al (2004) Design and synthesis of novel NM-3 antiangigenic analogues with increased potency and reduced protein binding. AACR 45:4087
12. Sudo T, Ota Y, Kotani S et al (2001) Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J 20:6499-6508
13. Kawano T, Horiguchi-Yamada J, Iwase S et al (2004) Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. Anticancer Res 24:2705-2712
14. Sasaki J, Ramesh R, Chada S et al (2002) The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther 1:1201-1209
15. Ling YH, Tornos C, Perez-Soler R (1998) Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 273:18984-18991
16. Castedo M, Perfettini JL, Roumier T et al (2004) Cell death by mitotic catastrophe: a molecular definition. Oncogene 23:2825-2837
17. Jordan MA, Wilson L (1998) Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10:123-130