SHBG levels correlate with insulin resistance in postmenopausal women

European Journal of Internal Medicine

Volumn 20, Issue 2, 2009, Pages 162-167

  Akin, Fulya ^a   Bastemir, Mehmet ^a   Alkiş, Esma ^a   Kaptanoglu, Bunyamin ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

Insulin resistance; Metabolic syndrome; Obesity; Sex hormone binding globulin; Sex hormones

Indexed keywords

FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; THYROID HORMONE;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; CONTROLLED STUDY; HORMONE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PREMENOPAUSE; WAIST CIRCUMFERENCE;

ADULT; AGED; BIOLOGICAL MARKERS; FEMALE; GLUCOSE INTOLERANCE; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; POSTMENOPAUSE; PREDIABETIC STATE; PREDICTIVE VALUE OF TESTS; PREMENOPAUSE; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX HORMONE-BINDING GLOBULIN;

EID: 62649107192     PISSN: 09536205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejim.2007.09.023     Document Type: Article

References (36)

1. Hammond G.L. Molecular properties of corticosteroid binding globulins and the sex-steroid binding proteins. Endocrine Reviews 17 (1990) 65-79
2. Rosner W. The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocrine Reviews 17 (1990) 80-91
3. Selby C. Sex hormone-binding globulin: origin, function and clinical significance. Annals of Clinical Biochemistry 27 (1990) 532-541
4. Kalme T., Seppala M., Qiao Q., Koistinen R., Nissinen A., Harrela M., et al. Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. J Clin Endocrinol Metab 90 (2005) 1550-1556
5. Ding E.L., Song Y., Malik V.S., and Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 295 (2006) 1288-1299
6. Tsai E.C., Matsumoto A.M., Fujimoto W.Y., and Boyko E.J. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 27 (2004) 861-868
7. Pitteloud N., Mootha V.K., Dwyer A.A., et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 28 (2005) 1636-1642
8. Muller M., Grobbee D.E., den Tonkelaar I., Lamberts S.W.J., and van der Schouw Y.T. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab 90 (2005) 2618-2623
9. Birkeland K.I., Hanssen K.F., Torjesen P.A., and Vaaler S. Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab. 76 (1993) 275-278
10. Kupelian V., Page S.T., Araujo A.B., Travison T.G., Bremner W.J., and McKinlay J.B. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 91 (2006) 843-850
11. Acien P., Quereda F., Matallin P., Villarroya E., Lopez-Fernandez J.A., Acien M., et al. Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders. Fertil Steril 72 (1999) 32-40
12. Björntorp P. Hyperandrogenicity in women-a prediabetic condition?. J Intern Med 234 (1993) 579-583
13. Von Eckardstein A. Androgens, cardiovascular risk factors and atherosclerosis. In: Nieschlag E., and Behre H.M. (Eds). Testosterone: action, deficiency, substitution. 2nd Edition (1998), Springer Verlag, Berlin, Germany 229-258
14. Reaven G.M. Role of insulin resistance in human disease. Diabetes 37 (1988) 1495-1607
15. Despres J.P. The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients risk. Obes Res 6 (1998) 8-17
16. Tchernof A., Labrie F., Belanger A., Prud'homme D., Bouchard C., Tremblay A., et al. Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis 133 (1997) 235-244
17. Pugeat M., Moulin P., Cousin P., Fimbel S., Nicolas M.H., Crave J.C., et al. Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk. J Steroid Biochem Mol Biol. 53 (1995) 567-572
18. Gascon F., Valle M., Martos R., Ruz F.J., Rios R., Montilla P., et al. Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children. Europ J Endocrin 143 (2000) 85-89
19. Hergenc G., Schulte H., Assmann G., and von Eckardstein A. Associations of obesity markers, insulin, and sex hormones with HDL cholesterol levels in Turkish and German individuals. Atherosclerosis 145 (1999) 147-156
20. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
21. Tchernof A., Toth M.J., and Poehlman E.T. Sex hormone-binding globulin levels in middle-aged premenopausal women (associations with visceral obesity and metabolic profile). Diabetes Care 22 (1999) 1875-1881
22. Lukanova A., Lundin E., Jacquette A.Z., Muti P., Mure A., Rinaldi S., et al. Body mass index, circulating levels of steroid hormones, IGF-1 and IGF-binding protein-3:a cross-sectional study in healthy women. Europ J Endocrin 150 (2004) 161-171
23. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama 285: 2486-2497
24. Tchernof A., and Despres J.P. Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women. Horm Metab Res 32 (2000) 526-536
25. Ivandic A., Prpic-Krizevac I., Sucic M., and Juric M. Hyperinsulinemia and sex hormones in healthy premenopausal women: relative contribution of obesity, obesity type, and duration of obesity. Metabolism 47 1 (1998) 13-19
26. Cikim A.S., Ozbey N., Sencer E., Molvalilar S., and Orhan Y. Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women. Diabetes Nutr Metab 17 (2004) 290-295
27. Puder J.J., Varga S., Kraenzlin M., De Geyter C., Keller U., and Müler B. Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance. The Journal of Clin Endocrinol Metab 90 (2005) 6014-6021
28. Lindstedt G., Lundberg P.A., Lapidus L., Lundgren H., Bengtsson C., and Bjorntorp P. Low sex hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of population study of women in Gothenburg, Sweden. Diabetes 40 (1991) 123-128
29. Reinecke H., Bogdanski J., Woltering A., Breithard G., Assmann G., Kerber S., et al. Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. Am J Cardiology 90 (2002) 364-368
30. Pasquali R., Vicennati V., Bertazzo D., Casimirri F., Pascal G., Tortelli O., et al., and the Virgilio-Menopause-Health Group. Determinants of sex hormone-binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status. Metabolism 46 (1997) 5-9
31. Nestler J.E. Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?. J Clin Endocrinol Metab 76 2 (Feb 1993) 273-274.
32. Preziosi P., Barrett-Connor E., Papoz L., Roger M., Saint-Paul M., Nahoul K., et al. Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: the telecom study. J Clin Endocrinol Metab 76 2 (Feb 1993) 283-287
33. Le May C., Chu K., Hu M., Ortega C.S., Simpson E.R., Korach K.S., et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A 103 24 (Jun 13 2006) 9232-9237 Electronic publication 2006 Jun 5
34. Poehlman E.T., Toth M.J., and Gardner A.W. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 123 (1995) 673-675
35. Evans D.J., Hoffmann R.G., Kalkhoff R.K., et al. Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 57 (1983) 304-310
36. Lee C.C., Kasa-Vubu J.Z., and Supiano M.A. Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. Metabolism. 53 (2004) 507-512