Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2

Journal of Neurochemistry

Volumn 109, Issue 2, 2009, Pages 631-643

  Doonan, Francesca ^a   Wallace, Deborah M ^a   O'Driscoll, Carolyn ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Oxidative stress; P53; Photoreceptor; Rosiglitazone; Sestrin; Superoxide dismutase 2

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CALCIUM; MANGANESE SUPEROXIDE DISMUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; PROTEIN P53; ROSIGLITAZONE; SESTRIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HORMONE RESPONSIVE ELEMENT; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; RETINA CELL; RETINA INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PHOTORECEPTOR CELLS, VERTEBRATE; SUPEROXIDE DISMUTASE; THIAZOLIDINEDIONES; UP-REGULATION;

EID: 62649105174     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05995.x     Document Type: Article

References (37)

1. Aoun P., Simpkins J. W. Agarwal N. (2003) Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 44, 2999 3004.
2. Brown K. K., Henke B. R., Blanchard S. G. et al. (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48, 1415 1424.
3. Budanov A. V., Shoshani T., Faerman A. et al. (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21, 6017 6031.
4. Budanov A. V., Sablina A. A., Feinstein E., Koonin E. V. Chumakov P. M. (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304, 596 600.
5. Caffe A. R., Ahuja P., Holmqvist B., Azadi S., Forsell J., Holmqvist I., Soderpalm A. K. van Veen T. (2001) Mouse retina explants after long-term culture in serum free medium. J. Chem. Neuroanat. 22, 263 273.
6. Dentchev T., Yao Y., Pratico D. Dunaief J. (2007) Isoprostane F2alpha-VI, a new marker of oxidative stress, increases following light damage to the mouse retina. Mol Vis. 13, 190 195.
7. Ding G., Fu M., Qin Q. et al. (2007) Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc. Res. 76, 269 279.
8. Donovan M., Carmody R. J. Cotter T. G. (2001) Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J. Biol. Chem. 276, 23000 23008.
9. Donovan M., Doonan F. Cotter T. G. (2006) Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death. Dev. Biol. 291, 154 169.
10. Doonan F., Donovan M. Cotter T. G. (2003) Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J. Neurosci. 23, 5723 5731.
11. Doonan F., Donovan M. Cotter T. G. (2005) Activation of multiple pathways during photoreceptor apoptosis in the rd mouse. Invest. Ophthalmol. Vis. Sci. 46, 3530 3538.
12. Doonan F., Donovan M., Gomez-Vicente V., Bouillet P. Cotter T. G. (2007) Bim expression indicates the pathway to retinal cell death in development and degeneration. J. Neurosci. 27, 10887 10894.
13. Ho T. C., Chen S. L., Yang Y. C., Liao C. L., Cheng H. C. Tsao Y. P. (2007) PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells. Cardiovasc. Res. 76, 213 223.
14. Inestrosa N. C., Godoy J. A., Quintanilla R. A., Koenig C. S. Bronfman M. (2005) Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp. Cell Res. 304, 91 104.
15. Joly S., Lange C., Thiersch M., Samardzija M. Grimm C. (2008) Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo. J. Neurosci. 28, 13765 13774.
16. Jung T. W., Lee J. Y., Shim W. S., Kang E. S., Kim S. K., Ahn C. W., Lee H. C. Cha B. S. (2007) Rosiglitazone protects human neuroblastoma SH-SY5Y cells against MPP+ induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production. J. Neurol. Sci. 253, 53 60.
17. Justilien V., Pang J. J., Renganathan K., Zhan X., Crabb J. W., Kim S. R., Sparrow J. R., Hauswirth W. W. Lewin A. S. (2007) SOD2 knockdown mouse model of early AMD. Invest. Ophthalmol. Vis. Sci. 48, 4407 4420.
18. Komeima K., Rogers B. S., Lu L. Campochiaro P. A. (2006) Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc. Natl Acad. Sci. USA 103, 11300 11305.
19. Komeima K., Rogers B. S. Campochiaro P. A. (2007) Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa. J. Cell. Physiol. 213, 809 815.
20. Lago R. M., Singh P. P. Nesto R. W. (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 370, 1129 1136.
21. Linseman D. A. (2008) Targeting oxidative stress for neuroprotection. Antioxid. Redox Signal. 11, 421 424.
22. Moncada S. Erusalimsky J. D. (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat. Rev. Mol. Cell Biol. 3, 214 220.
23. Montoliu C., Llansola M., Saez R., Yenes S., Messeguer A. Felipo V. (1999) Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide. Biochem. Pharmacol. 58, 255 261.
24. Nissen S. E. Wolski K. (2007) Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356, 2457 2471.
25. O'Connor J. C., Wallace D. M., O'Brien C. Cotter T. G. (2008) A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell. Invest. Ophthalmol. Vis. Sci. 49, 4237 4244.
26. Panigrahy D., Singer S., Shen L. Q. et al. (2002) PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J. Clin. Invest. 110, 923 932.
27. Qin S., McLaughlin A. P. De Vries G. W. (2006) Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. Invest. Ophthalmol. Vis. Sci. 47, 5098 5105.
28. Quintanilla R. A., Jin Y. N., Fuenzalida K., Bronfman M. Johnson G. V. (2008) Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease. J. Biol. Chem. 283, 25628 25637.
29. Rattner A. Nathans J. (2005) The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia. J. Neurosci. 25, 4540 4549.
30. Sablina A. A., Budanov A. V., Ilyinskaya G. V., Agapova L. S., Kravchenko J. E. Chumakov P. M. (2005) The antioxidant function of the p53 tumor suppressor. Nat. Med. 11, 1306 1313.
31. Shiojiri T., Wada K., Nakajima A. et al. (2002) PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Eur. J. Pharmacol. 448, 231 238.
32. Sokolov M., Strissel K. J., Leskov I. B., Michaud N. A., Govardovskii V. I. Arshavsky V. Y. (2004) Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse. J. Biol. Chem. 279, 19149 19156.
33. Tomita H., Kotake Y. Anderson R. E. (2005) Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. Invest. Ophthalmol. Vis. Sci. 46, 427 434.
34. Velasco-Miguel S., Buckbinder L., Jean P., Gelbert L., Talbott R., Laidlaw J., Seizinger B. Kley N. (1999) PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Oncogene 18, 127 137.
35. Wada K., Nakajima A., Katayama K. et al. (2006) Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. J. Biol. Chem. 281, 12673 12681.
36. Zand H., Rhimipour A., Bakhshayesh M., Shafiee M., Nour Mohammadi I. Salimi S. (2007) Involvement of PPAR-gamma and p53 in DHA-induced apoptosis in Reh cells. Mol. Cell. Biochem. 304, 71 77.
37. Zhao X., Ou Z., Grotta J. C., Waxham N. Aronowski J. (2006) Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity. Brain Res. 1073-1074, 460 469.