Regulation of Spo12 Phosphorylation and Its Essential Role in the FEAR Network

Current Biology

Volumn 19, Issue 6, 2009, Pages 449-460

  Tomson, Brett N ^a   Rahal, Rami ^a   Reiser, Vladimír ^a   Monje Casas, Fernando ^a   Mekhail, Karim ^b   Moazed, Danesh ^b   Amon, Angelika ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

DNA; SIGNALING

Indexed keywords

CELL CYCLE PROTEIN; FUNGAL DNA; MICROTUBULE ASSOCIATED PROTEIN; NUCLEAR PROTEIN; PROTEINASE; RIBOSOME DNA; SACCHAROMYCES CEREVISIAE PROTEIN; SEPARASE; SLK19 PROTEIN, S CEREVISIAE; SPO12 PROTEIN, S CEREVISIAE;

ANAPHASE; ARTICLE; CELL CYCLE; CYTOLOGY; GENETICS; METABOLISM; MITOSIS; MITOSIS SPINDLE; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE;

ANAPHASE; CELL CYCLE; CELL CYCLE PROTEINS; DNA, FUNGAL; DNA, RIBOSOMAL; ENDOPEPTIDASES; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCETALES;

EID: 62549159488     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.02.024     Document Type: Article

References (31)

1. Visintin R., Craig K., Hwang E.S., Prinz S., Tyers M., and Amon A. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2 (1998) 709-718
2. Visintin R., Hwang E.S., and Amon A. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398 (1999) 818-823
3. Stegmeier F., and Amon A. Regulation of mitotic exit. Annu. Rev. Genet. 38 (2004) 203-232
4. D'Amours D., and Amon A. At the interface between signaling and executing anaphase-Cdc14 and the FEAR network. Genes Dev. 18 (2004) 2581-2595
5. Queralt E., Lehane C., Novak B., and Uhlmann F. Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125 (2006) 719-732
6. Queralt E., and Uhlmann F. Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J. Cell Biol. 182 (2008) 873-883
7. Azzam R., Chen S.L., Shou W., Mah A.S., Alexandru G., Nasmyth K., Annan R.S., Carr S.A., and Deshaies R.J. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 305 (2004) 516-519
8. Shou W., Seol J.H., Shevchenko A., Baskerville C., Moazed D., Chen Z.W., Jang J., Shevchenko A., Charbonneau H., and Deshaies R.J. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97 (1999) 233-244
9. Stegmeier F., Visintin R., and Amon A. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell 108 (2002) 207-220
10. Visintin R., Stegmeier F., and Amon A. The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol. Biol. Cell 14 (2003) 4486-4498
11. Stegmeier F., Huang J., Rahal R., Zmolik J., Moazed D., and Amon A. The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr. Biol. 14 (2004) 467-480
12. Klapholz S., and Esposito R.E. Isolation of SPO12-1 and SPO13-1 from a natural variant of yeast that undergoes a single meiotic division. Genetics 96 (1980) 567-588
13. Shah R., Jensen S., Frenz L.M., Johnson A.L., and Johnston L.H. The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex. Genetics 159 (2001) 965-980
14. Hu F., Wang Y., Liu D., Li Y., Qin J., and Elledge S.J. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell 107 (2001) 655-665
15. Pereira G., Manson C., Grindlay J., and Schiebel E. Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p. J. Cell Biol. 157 (2002) 367-379
16. Geymonat M., Spanos A., Walker P.A., Johnston L.H., and Sedgwick S.G. In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. J. Biol. Chem. 278 (2003) 14591-14594
17. Lew D.J., and Burke D.J. The spindle assembly and spindle position checkpoints. Annu. Rev. Genet. 37 (2003) 251-282
18. Nasmyth K. Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis. Annu. Rev. Genet. 35 (2001) 673-745
19. Surana U., Amon A., Dowzer C., Mcgrew J., Byers B., and Nasmyth K. Destruction of the CDC28/CLB kinase is not required for metaphase/anaphase transition in yeast. EMBO J. 12 (1993) 1969-1978
20. Grether M.E., and Herskowitz I. Genetic and biochemical characterization of the yeast spo12 protein. Mol. Biol. Cell 10 (1999) 3689-3703
21. Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 (2000) 395-401
22. Ciosk R., Zachariae W., Michaelis C., Shevchenko A., Mann M., and Nasmyth K. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93 (1998) 1067-1076
23. Traverso E.E., Baskerville C., Liu Y., Shou W., James P., Deshaies R.J., and Charbonneau H. Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast. J. Biol. Chem. 276 (2001) 21924-21931
24. Yellman C.M., and Burke D.J. The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. Mol. Biol. Cell 17 (2006) 658-666
25. Shou W., Azzam R., Chen S.L., Huddleston M.J., Baskerville C., Charbonneau H., Annan R.S., Carr S.A., and Deshaies R.J. Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. BMC Mol. Biol. 3 (2002) 3
26. Geil C., Schwab M., and Seufert W. A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr. Biol. 18 (2008) 1001-1015
27. Huang J., and Moazed D. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 17 (2003) 2162-2176
28. Huang J., Brito I.L., Villén J., Gygi S.P., Amon A., and Moazed D. Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 20 (2006) 2887-2901
29. Jaspersen S.L., and Morgan D.O. Cdc14 activates Cdc15 to promote mitotic exit in budding yeast. Curr. Biol. 10 (2000) 615-618
30. Tomson B.N., D'Amours D., Adamson B.S., Aragon L., and Amon A. Ribosomal DNA transcription-dependent processes interfere with chromosome segregation. Mol. Cell. Biol. 26 (2006) 6239-6247
31. Carvalho P., Gupta Jr. M.L., Hoyt M.A., and Pellman D. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev. Cell 6 (2004) 815-829