Anti-Sm B cell tolerance and tolerance loss in systemic lupus erythematosus

Immunologic Research

Volumn 41, Issue 3 SPEC. ISS., 2008, Pages 203-216

  Clarke, Stephen H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Anergy; B lymphocytes; Dendritic cells; Sm; Systemic lupus erythematosus; Tolerance

Indexed keywords

AUTOANTIGEN; SMITH ANTIGEN; UNCLASSIFIED DRUG;

APOPTOSIS; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL ACTIVATION; CLONAL ANERGY; DENDRITIC CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; SNRNP CORE PROTEINS;

EID: 62549120754     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-008-8023-3     Document Type: Review

References (66)

1. BH Hahn 1998 Antibodies to DNA N Engl J Med 338 19 1359 68
2. W Su MP Madaio 2003 Recent advances in the pathogenesis of lupus nephritis: autoantibodies and B cells Semin Nephrol 23 6 564 8
3. E Ciruelo J de la Cruz I Lopez JJ Gomez-Reino 1996 Cumulative rate of relapse of lupus nephritis after successful treatment with cyclophosphamide Arthritis Rheum 39 12 2028 34
4. GG Illei K Takada D Parkin HA Austin M Crane CH Yarboro 2002 Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: long-term followup of a cohort of 145 patients participating in randomized controlled studies Arthritis Rheum 46 4 995 1002
5. PH Nachman SL Hogan JC Jennette RJ Falk 1996 Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis J Am Soc Nephrol 7 1 33 9
6. JB Harley ME Alarcon-Riquelme LA Criswell CO Jacob RP Kimberly KL Moser 2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet 40 2 204 10
7. G Hom RR Graham B Modrek KE Taylor W Ortmann S Garnier 2008 Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX N Engl J Med 358 9 900 9
8. L Truedsson AA Bengtsson G Sturfelt 2007 Complement deficiencies and systemic lupus erythematosus Autoimmunity 40 8 560 6
9. AP Manderson M Botto MJ Walport 2004 The role of complement in the development of systemic lupus erythematosus Annu Rev Immunol 22 431 56
10. SP Hart JR Smith I Dransfield 2004 Phagocytosis of opsonized apoptotic cells: roles for 'old-fashioned' receptors for antibody and complement Clin Exp Immunol 135 2 181 5
11. LA Casciola-Rosen G Anhalt A Rosen 1994 Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes J Exp Med 179 4 1317 30
12. A Rosen L Casciola-Rosen 1999 Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease Cell Death Differ 6 1 6 12
13. Y Qian H Wang SH Clarke 2004 Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells J Immunol 172 1 625 35
14. D Mevorach JL Zhou X Song KB Elkon 1998 Systemic exposure to irradiated apoptotic cells induces autoantibody production J Exp Med 188 2 387 92
15. J Yong L Wan G Dreyfuss 2004 Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol 14 5 226 32
16. EM Tan 1989 Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology Adv Immunol 44 93 151
17. S Santulli-Marotto MW Retter R Gee MJ Mamula SH Clarke 1998 Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens Immunity 8 2 209 19
18. DD Bloom JL Davignon MW Retter MJ Shlomchik DS Pisetsky PL Cohen 1993 V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice J Immunol 150 4 1591 610
19. M Borrero SH Clarke 2002 Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1 J Immunol 168 1 13 21
20. S Santulli-Marotto Y Qian S Ferguson SH Clarke 2001 Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response J Immunol 166 8 5292 9
21. Y Qian KL Conway X Lu HM Seitz GK Matsushima SH Clarke 2006 Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance Blood 108 3 974 82
22. CC Goodnow JG Cyster SB Hartley SE Bell MP Cooke JI Healy 1995 Self-tolerance checkpoints in B lymphocyte development Adv Immunol 59 279 368
23. D Gay T Saunders S Camper M Weigert 1993 Receptor editing: an approach by autoreactive B cells to escape tolerance J Exp Med 177 4 999 1008
24. D Nemazee M Weigert 2000 Revising B cell receptors J Exp Med 191 11 1813 7
25. L Mandik-Nayak A Bui H Noorchashm A Eaton J Erikson 1997 Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle J Exp Med 186 8 1257 67
26. JG Cyster SB Hartley CC Goodnow 1994 Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire Nature 371 6496 389 95
27. DA Culton BP O'Conner KL Conway R Diz J Rutan BJ Vilen 2006 Early preplasma cells define a tolerance checkpoint for autoreactive B cells J Immunol 176 2 790 802
28. J William C Euler N Primarolo MJ Shlomchik 2006 B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation J Immunol 176 4 2142 51
29. KT Merrell RJ Benschop SB Gauld K Aviszus D Decote-Ricardo LJ Wysocki 2006 Identification of anergic B cells within a wild-type repertoire Immunity 25 6 953 62
30. MA Kilmon JA Rutan SH Clarke BJ Vilen 2005 Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages J Immunol 175 1 37 41
31. Y Qian C Santiago M Borrero TF Tedder SH Clarke 2001 Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds J Immunol 166 4 2412 9
32. MA Kilmon NJ Wagner AL Garland L Lin K Aviszus LJ Wysocki 2007 Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and IL-6 Blood 110 1595 602
33. T Lopes-Carvalho JF Kearney 2004 Development and selection of marginal zone B cells Immunol Rev 197 192 205
34. T Lopes-Carvalho JF Kearney 2005 Marginal zone B cell physiology and disease Curr Dir Autoimmun 8 91 123
35. AM Oliver F Martin GL Gartland RH Carter JF Kearney 1997 Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses Eur J Immunol 27 9 2366 74
36. P Quartier PK Potter MR Ehrenstein MJ Walport M Botto 2005 Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro Eur J Immunol 35 1 252 60
37. R Lesley Y Xu SL Kalled DM Hess SR Schwab HB Shu JG Cyster 2004 Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF Immunity 20 4 441 53
38. RS Scott EJ McMahon SM Pop EA Reap R Caricchio PL Cohen 2001 Phagocytosis and clearance of apoptotic cells is mediated by MER Nature 411 6834 207 11
39. R Watanabe-Fukunaga CI Brannan NG Copeland NA Jenkins S Nagata 1992 Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Nature 356 6367 314 7
40. AN Theofilopoulos FJ Dixon 1985 Murine models of systemic lupus erythematosus Adv Immunol 37 269 390
41. M Gerloni D Lo M Zanetti 1998 DNA immunization in relB-deficient mice discloses a role for dendritic cells in IgM→IgG1 switch in vivo Eur J Immunol 28 2 516 24
42. G MacPherson N Kushnir M Wykes 1999 Dendritic cells, B cells and the regulation of antibody synthesis Immunol Rev 172 325 34
43. H Qi JG Egen AY Huang RN Germain 2006 Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells Science 312 5780 1672 6
44. M Balazs F Martin T Zhou J Kearney 2002 Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses Immunity 17 3 341 52
45. I Baumann W Kolowos RE Voll B Manger U Gaipl WL Neuhuber 2002 Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus Arthritis Rheum 46 1 191 201
46. Q Lu G Lemke 2001 Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family Science 293 5528 306 11
47. Z Guo M Zhang H An W Chen S Liu J Guo 2003 Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways Blood 102 13 4441 7
48. MJ Shlomchik AH Aucoin DS Pisetsky MG Weigert 1987 Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse Proc Natl Acad Sci USA 84 24 9150 4
49. MJ Shlomchik A Marshak-Rothstein CB Wolfowicz TL Rothstein MG Weigert 1987 The role of clonal selection and somatic mutation in autoimmunity Nature 328 6133 805 11
50. RM Blaese J Grayson AD Steinberg 1980 Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus Am J Med 69 3 345 50
51. DR Budman EB Merchant AD Steinberg B Doft ME Gershwin E Lizzio 1977 Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE Arthritis Rheum 20 3 829 33
52. H Suzuki T Sakurami H Imura 1982 Relationship between reduced B cell susceptibility to IgM antibodies and reduced IgD-bearing B cells in patients with systemic lupus erythematosus Arthritis Rheum 25 12 1451 9
53. SN Liossis B Kovacs G Dennis GM Kammer GC Tsokos 1996 B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events J Clin Invest 98 11 2549 57
54. GC Tsokos HK Wong EJ Enyedy MP Nambiar 2000 Immune cell signaling in lupus Curr Opin Rheumatol 12 5 355 63
55. M Bijl G Horst PC Limburg CG Kallenberg 2001 Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus Ann Rheum Dis 60 5 523 6
56. D Folzenlogen MF Hofer DY Leung JH Freed MK Newell 1997 Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients Clin Immunol Immunopathol 83 3 199 204
57. M Odendahl A Jacobi A Hansen E Feist F Hiepe GR Burmester 2000 Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus J Immunol 165 10 5970 9
58. AM Jacobi M Odendahl K Reiter A Bruns GR Burmester A Radbruch 2003 Correlation between circulating CD27 high plasma cells and disease activity in patients with systemic lupus erythematosus Arthritis Rheum 48 5 1332 42
59. HR Smith RR Olson 1990 CD5+ B lymphocytes in systemic lupus erythematosus and rheumatoid arthritis J Rheumatol 17 6 833 5
60. DA Culton MW Nicholas DO Bunch QL Zhen TB Kepler MA Dooley 2007 Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss J Clin Immunol 27 1 53 68
61. RJ Falk JC Jennette 1988 Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis N Engl J Med 318 25 1651 7
62. JC Jennette JR Hoidal RJ Falk 1990 Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3 Blood 75 11 2263 4
63. JC Jennette RJ Falk 1997 Small-vessel vasculitis N Engl J Med 337 21 1512 23
64. MW Nicholas MA Dooley SL Hogan J Anolik J Looney I Sanz 2008 A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE Clin Immunol 126 2 189 201
65. S Narumi T Takeuchi Y Kobayashi K Konishi 2000 Serum levels of ifn-inducible PROTEIN-10 relating to the activity of systemic lupus erythematosus Cytokine 12 10 1561 5
66. H Okamoto Y Katsumata K Nishimura N Kamatani 2004 Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupus Arthritis Rheum 50 11 3731 2