Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme

Journal of Magnetic Resonance Imaging

Volumn 15, Issue 3, 2002, Pages 233-240

  Gossmann, Axel ^a,c   Helbich, Thomas H ^a   Kuriyama, Nagato ^a   Ostrowitzki, S ^a   Roberts, Timothy P L ^a   Shames, David M ^a   van Bruggen, N ^b   Wendland, Michael F ^a   Israel, Mark A ^a   Brasch, Robert C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Angiogenesis inhibition; Contrast enhanced; Glioblastoma multiforme; Microvascular permeability; MRI; Tumor treatment monitoring

Indexed keywords

ANGIOGENESIS INHIBITOR; GADOLINIUM PENTETATE; GADOLINIUM PENTETATE MEGLUMINE; MONOCLONAL ANTIBODY A4.6.1; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER GROWTH; CANCER INHIBITION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; MICROVASCULATURE; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; PRIORITY JOURNAL; RAT; TUMOR VOLUME; TUMOR XENOGRAFT; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CONTRAST MEDIA; ENDOTHELIAL GROWTH FACTORS; GLIOBLASTOMA; MAGNETIC RESONANCE IMAGING; RATS; RATS, NUDE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036189478     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.10072     Document Type: Article

References (31)

1. Brain tumors
2. Angiogenesis in malignant gliomas
3. Vascular endothelial growth factor: Basic biology and clinical implications
4. Vascular endothelial growth factor is a secreted angiogenic mitogen
5. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
6. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
7. Regulation by vascular endothelial growth factor of human colon cancer tumorgenesis in a mouse model of experimental liver metastasis
8. The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
9. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
10. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
11. Prostate cancer tumor grade differentiation with dynamic contrast-enhanced MR imaging in the rat: Comparison of macromolecular and small-molecular contrast media - Preliminary experience
12. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
13. Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: A quantitative noninvasive technique
14. Comparison of gadopentetate dimeglumine and albumin-(Gd-DTPA)30 for microvessel characterization in an intracranial glioma model
15. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
16. Development of an animal brain tumor model and its response to therapy with 1,3-Bis(2-chloroethyl)-1-nitrosourea
17. "Keyhole" method for accelerating imaging of contrast agent uptake
18. Physiologic measurements by contrast-enhanced MR imaging: Expectations and limitations
19. Quantification of liver blood volume: Comparison of ultra short TI inversion recovery echo planar imaging (ULSTIR-EPI), with dynamic 3D-gradient recalled echo imaging
20. Quantification of tissue gadolinium concentration using magnetic resonance imaging: Comparison of ultrashort inverson time inversion recovery echoplanar and three-dimensional spoiled gradient-recalled approaches with in vitro measurements
21. Principles of nuclear relaxation
22. Relaxation of water protons in the intra- and extracellular regions of blood containing Gd(DTPA)
23. Correlation of dynamic contrast-enhanced magnetic resonance imaging with histologic tumor grade: Comparison of macromolecular and small-molecular contrast media
24. Induction of angiogenesis during the transition from hyperplasia to neoplasia
25. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
26. Pathogenesis of ascites tumor growth: Vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation
27. Pathogenesis of tumor stroma generation: A critical role for leaky blood vessels and fibrin deposition
28. Mammary carcinoma model: Correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density
29. Correlation of microvascular permeability derived from dynamic contrast-enhanced MR imaging with histologic grade and tumor labeling index: A study in human brain tumors
30. Complete Inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
31. Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor